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Phenylephrine hydrochloride

CAS No. 61-76-7
Chemical Name: Phenylephrine hydrochloride
Synonyms: uri;fenox;efricel;emagrin;lexatol;rhinall;synasal;consdrin;almefrin;fenilfar
CBNumber: CB6762113
Molecular Formula: C9H14ClNO2
Formula Weight: 203.67
MOL File: 61-76-7.mol
Phenylephrine hydrochloride Property
Melting point : 143-145 °C(lit.)
alpha : -47 º (c=2, H2O)
refractive index : -45.5 ° (C=1, H2O)
Fp : 9℃
storage temp. : Desiccate at RT
form : Crystalline Powder
color : White to almost white
Water Solubility : >=10 g/100 mL at 21 ºC
Merck : 7286
CAS DataBase Reference: 61-76-7(CAS DataBase Reference)
EPA Substance Registry System: Benzenemethanol, 3-hydroxy-.alpha.-[(methylamino) methyl]-, hydrochloride, (.alpha.R)-(61-76-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn,T,F
Risk Statements : 22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements : 26-36-37/39-45-36/37-16-7
RIDADR : 3249
WGK Germany : 3
RTECS : DO7525000
HazardClass : 6.1(b)
PackingGroup : III
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Phenylephrine hydrochloride Chemical Properties,Usage,Production

Chemical Properties
white to almost white crystalline powder
Uses
α-Adrenergic agonist. Mydriatic; decongestant.
Uses
DECONGESTANTS
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.
General Description
Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light. Water soluble.
Reactivity Profile
Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.
Fire Hazard
Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.
Biological Activity
α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.
Phenylephrine hydrochloride Preparation Products And Raw materials
Raw materials
Benzyl alcohol Toluene Diethyl ether
Preparation Products
Phenylephrine hydrochloride Suppliers      Global( 208)Suppliers     
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61-76-7(Phenylephrine hydrochloride)Related Search:
PHOMOPSIN A (R)-A,A-BIS(3-METHOXYPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE (1R,2S)-(-)META-HYDROXYEPHEDRINE HYDROCHLORIDE Naxagolide N-[(1R,2R)-1,2,3,4-TETRAHYDRO-1-HYDROXY-7-METHOXY-2-NAPHTHALENYL]-CHLOROACETAMIDE (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Chenodeoxycholic acid Phenylephrine DL-PHENYLEPHRINE HYDROCHLORIDE CHLOROPHOSPHONAZO III Phenylephrine hydrochloride Benzyl alcohol L(-)-Epinephrine Benzyl Ethyl acetate Topotecan hydrochloride Ursodeoxycholic acid Isoprenaline hydrochloride
Adrenergic Agents (-)-3-[1(R)-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride Phenylephrine Hydrochloride (200 mg) pharmaceutical raw material Pharmaceutical intermediates PHENYLEPHRINE HCL BP ((R)-3-HYDROXY-ALPHA-(METHYLAMINO) METHYL] BENZENEMETHANOLHYDROCHL ORIDE) )-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride (R)-(− Phenylephring Hydrochloride (R)-(− (-)-alpha-hydroxy-beta-(methylamino)ethyl-alpha-(3-hydroxybenzene)hydrochlor 1-m-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride 3-hydroxy-alpha-((methylamino)methyl)-,hydrochloride,(-)-benzenemethano almefrin benzenemethanol,3-hydroxy-alpha-[(methylamino)methyl]-,hydrochloride,(thet consdrin consdrinhydrochloride d-(-)-phenylephrinehydrochloride efricel emagrin fenilfar fenox histabid idrianol isophrinehydrochloride isophrinhydrochloride lexatol meta-synephrinehydrochloride metroxedrine nci-c55641 neooxedrinechloride neosympatol neosynephrinehydrochloride neo-synesin1 oftalfrine op-isophrin phenistan PhenylephringHydrochloride pyristan rhinall stanephrin sucraphen synasal synethenate uri (-)-3-HYDROXY-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL HYDROCHLORIDE 61-76-7 Chiral Auxiliaries Asymmetric Synthesis L-1-(M-HYDROXYPHENYL)-2-METHYLAMINOETHANOL HYDROCHLORIDE L-(3-HYDROXYPHENYL)-N-METHYLETHANOLAMINEHYDROCHLORIDE L-A-HYDROXY-B-METHYLAMINO-3-HYDROXY-1-ETHYLBENZENE HYDROCHLORIDE L(-)-PHENYLEPHRINE HCL L-PHENYLEPHRINE HCL L(-)-PHENYLEPHRINE HYDROCHLORIDE L-PHENYLEPHRINE HYDROCHLORIDE L-M-HYDROXY-A-[(METHYLAMINO)METHYL]BENZYL ALCOHOL HYDROCHLORIDE M-METHYLAMINOETHANOLPHENOL HYDROCHLORIDE PHENYLEPHRINE HCL (-)-PHENYLEPHRINE HYDROCHLORIDE
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