ChemicalBook
Chinese Japanese Germany

Triclosan

Disinfectants Carcinogenicity Toothpaste Standard Chemical Properties Uses Production method
Triclosan
Triclosan
CAS No.
3380-34-5
Chemical Name:
Triclosan
Synonyms
ch3565;IRGASAN;TROX-100;TRICLOSAN;Cloxifenol;ZilesanUW.;TRICHLOSAN;Irgacare MP;irgasandp300;Trichlorosan
CBNumber:
CB6771432
Molecular Formula:
C12H7Cl3O2
Formula Weight:
289.54
MOL File:
3380-34-5.mol

Triclosan Properties

Melting point:
56-60 °C(lit.)
storage temp. 
Refrigerator
solubility 
H2O: soluble12g/L at 20°C
pka
pKa 7.9
color 
colorless or white
Water Solubility 
Soluble in ethanol, methanol, diethyl ether and sodium hydroxide solution (1M). Slightly soluble in water.
Merck 
14,9657
BRN 
2057142
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
3380-34-5(CAS DataBase Reference)
NIST Chemistry Reference
Triclosan(3380-34-5)
EPA Substance Registry System
Phenol, 5-chloro-2-(2,4-dichlorophenoxy)- (3380-34-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,N
Risk Statements  36/38-50/53-36/37/38
Safety Statements  26-39-46-60-61-24/25-22-36
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  KO1100000
TSCA  Yes
HazardClass  9
PackingGroup  III
Hazardous Substances Data 3380-34-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P321 Specific treatment (see … on this label).
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Triclosan price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1682206 Triclosan United States Pharmacopeia (USP) Reference Standard 3380-34-5 200mg $342.9 2017-11-08 Buy
Sigma-Aldrich 647950-M Triclosan 3380-34-5 1gm-m $74 2017-11-08 Buy
Alfa Aesar L18655 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 99% 3380-34-5 10g $25.6 2017-11-08 Buy
Alfa Aesar L18655 5-Chloro-2-(2,4-dichlorophenoxy)phenol, 99% 3380-34-5 100g $139 2017-11-08 Buy
Sigma-Aldrich PHR1338 Triclosan Pharmaceutical Secondary Standard; Certified Reference Material 3380-34-5 1g $58.7 2017-11-08 Buy

Triclosan Chemical Properties,Uses,Production

Disinfectants

Triclosan is an efficient broad-spectrum topical antimicrobial disinfectant which is normally white or off-white crystalline powder. It has a slightly phenolic odor. It is insoluble in water but easily soluble in organic solvents and alkali. It has a relative stable chemical property and is heating-resistant and also resistant to acid and alkali hydrolysis without generating any symptoms of the toxicity and environmental pollution. It is internationally recognized as a fungicide variety with specific efficacy. It can kill bacteria such as Staphylococcus aureus, Escherichia coli and fungi such as Candida albicans. It also has an inhibitory effect on the virus (e.g., hepatitis B virus, etc.) while being able to protect the beneficial bacteria. The mechanism of action of triclosan is as below: it is first adsorbed on the bacterial cell wall and then further penetrates through the cell wall and has reaction with the lipid and protein in the cytoplasm, and thus resulting in protein denaturation which further kill the bacteria. Currently it has been widely applied to highly-efficient medicated soap (health soap, health lotion), removing underarm odor (foot aerosol), hand sanitizer, wound disinfectant sprays, medical equipment disinfectants, hygiene cleanser (cream), and air fresheners and refrigerator deodorants and some other daily chemicals. It is also used for the cleaning of the health fabric and the anti-corrosion treatment of plastics. Its high purity version can be added to the toothpaste and mouthwash for treatment of gingivitis, periodontitis and oral ulcers. The State content must not exceed 0.3%.

Carcinogenicity

In 2004, a teacher (Dr. Peter Vikesland) from the Virginia Tech University (US) had found from the experiments that the reaction between the triclosan-containing product and the chlorine-containing tap water containing can generate a substance known as "chloroform aryl", that is, chloroform (chemical name: trichloromethane) which is a colorless, volatile liquid with a special sweetness. Upon exposure to light, it will be oxidized to generate hydrogen chloride and phosgene. It had been once used as an anesthetic. Animal experiments have found that this substance will do harm to the heart and liver with mild teratogenicity and can induce the liver cancer of mice. However, so far no studies on the human carcinogenicity have been reported. For insurance purposes, both the International Cancer Research Centre and the United States have already has the chloroform be listed as suspected carcinogens to the human body.

Toothpaste Standard

The national standard of the toothpaste used in China is the new national standard of toothpaste (GB8372-2008) implemented on February 1, 2009. Compared with the 2001 version of toothpaste standard, the new national standard has been supplemented and adjusted in various aspects. In the new national standard of toothpaste, the prohibited or restricted ingredients include nearly 1,500 kinds, including diethylene glycol and triclosan. The provision of diethylene glycol is that it is not allowed to artificially add it to the raw materials, such as being introduced as impurities. Its content in the toothpaste should not exceed 0.1%. Triclosan were listed as being allowable preservatives but with the usage amount not exceeding 0.3%. The new national standard has ruled that the fluorine content of the fluoride-containing toothpaste should be within the range of 0.04%-0.15%, and the fluoride content should be within the range of 0.05% to 011% for children fluoride-containing toothpaste.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Chemical Properties

It is colorless and long needle-like crystals with a melting point being around 54-57.3 ℃ (60-61 ℃). It is slightly soluble in water and soluble in ethanol, acetone, ethyl ether and alkali solution. It has a chloro-phenol odor.

Uses

1. It can be used as antiseptic and fungicide and applied to cosmetics, emulsions and resins; also can be used for the manufacture of disinfection medicated soap. The LD50 of mice subject to oral administration of this product is 4g/kg.
2. It can be used for the production of top-grade daily chemical product, the disinfectants of medical instrument as well as diet instrument as well as the preparation of the anti-bacterial, deodorant finishing agent of fabric.
3. It can also be applied to biochemical studies. It is a kind of broad-spectrum antimicrobial agents which inhibit the type II fatty acid synthase (FAS-II) of bacteria and parasites, and also inhibits the mammalian fatty acid synthase (FASN), and may also have anticancer activity

Production method

1. Take 2, 4-dichloro-phenol as the raw material; use 2,4-dichloro-phenol to react with potassium hydroxide to generate dichlorophenol potassium which further reacts with 2,5-dichloro-nitrobenzene in the catalysis of copper for generation of 2,4,4-trichloro-2'-nitro diphenyl ether. It is further reduced by iron powder to generate 2, 4, 4-trichloro-2'-amino diphenyl ether, and then further went through diazotization hydrolysis to obtain the product.
2. Take o-methoxyphenol as the raw material: have potassium hydroxide powder reacted with guaiacol to generate guaiacol potassium. Apply reaction between bromobenzene and methoxy ether, together with chlorine for chlorination to obtain 2, 4, 4’-trichloro-2'-methoxydiphenyl ether. Take AICI3 as hydrolysis catalyst to generate 2,4,4'-trichloro-2'-hydroxydiphenyl ether.

Chemical Properties

Solid

Uses

Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.

Uses

anticonvulsant

Definition

ChEBI: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodo ants as well as in household items such as plastic chopping boards, sports equipment and shoes.

Triclosan Preparation Products And Raw materials

Raw materials

Preparation Products


Triclosan Suppliers

Global( 304)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
Jiangsu Equalchem Co., Ltd +86-513-80923038,83887909
+86-513-83887908 sherpdress@126.com China 12 60
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
Wuhan HongxinKang Fine Chemical Co., Ltd. 027-59362599 18674037007
027-84802889 zhuoxingwc@163.com China 942 58
Hubei ZhengXingyuan Chemical Co., Ltd. 027-87879181 18271418954/027-87879183 18707110115
027-87879181 2987332033@qq.com China 306 58
Tianjin Zhongxin Chemtech Co., Ltd. 86(0)22-89880739
86(0)22-89880739 ext 8030 / 86-22-66880086 sales@tjzxchem.com China 554 60
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6035 61
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30314 84
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 sales@RHFChem.com China 2364 56

3380-34-5(Triclosan)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved