3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride
- CAS No.
- 7059-23-6
- Chemical Name:
- 3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride
- Synonyms
- Mitoguazone 2HCl;Mitoguazone Dihydrochloride;3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride
- CBNumber:
- CB6901439
- Molecular Formula:
- C5H14Cl2N8
- Molecular Weight:
- 257.12426
- MDL Number:
- MOL File:
- 7059-23-6.mol
| Melting point | 256 °C (decomp) |
|---|---|
| storage temp. | -20° |
| solubility | Soluble in Water (greater than 25 mg/ml). |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month. |
| FDA UNII | NNI098FX5Q |
3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Chemical Properties,Uses,Production
Description
Mitoguazone (7059-23-6) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2?SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3?Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been looked at as a potential anti-cancer treatment because of its ability to inhibit polyamine synthesis.6
Definition
ChEBI: A hydrochloride obtained by combining mitoguazone with two molar equivalents of hydrochloric acid.
References
1) Wiliams?et al., (1971),?Methylglyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases; Biochem. Biophys. Res. Commun.,?46?288 2) Corti?et al., (1974),?Specific inhibition of enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances; Biochem. J.,?139?351 3) Williams-Ashman and Seidenfeld, (1986),?Aspects of the biochemical pharmacology of methylglyoxal bis(guanylhydrazone); Biochem. Pharmacol.,?35?1217 4) Janne and Morris, (1984),?Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation; Biochem. J.,?218?947 5) Pegg?et al., (1985)?Induction of spermidine/spermine N-acetyltransferase by methylglyoxal bis(guanylhydrazone); Biochim. Biophys. Acta,?842?111 6) Porter and Janne (2012)?Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis. In Inhibition of polyamine metabolism: Biological Significance and Basis for new Therapies; McCann, Ed.; Elsevier; pp.203-248
3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3,3'-(1-methylethane-1,2-diylidene)dicarbazamidine dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10007 | 58 |
| Supplier | Advantage |
|---|---|
| Shaanxi Dideu Newmaterial Co., Ltd. | 58 |