7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS No.
- 73942-87-7
- Chemical Name:
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- Synonyms
- 8-Dimethoxy-1;Ivabradine Impurity 13;Ivabradine Impurity 73;Ivabradine Impurity 22;3-dihydro-2H-3-benzazepin-2-one;7,8-diMethoxy-1H-benzo[d]azepin-2(3H)-one;7,8-dimethoxy-1,3-dihydro-1-benzazepin-2-one;7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one;7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one>1,3-Dihydro-7,8-dimethoxybenzo[d]azepin-2-one
- CBNumber:
- CB71503994
- Molecular Formula:
- C12H13NO3
- Molecular Weight:
- 219.24
- MDL Number:
- MFCD02091565
- MOL File:
- 73942-87-7.mol
Melting point | 244.0 to 248.0 °C |
---|---|
Boiling point | 455.8±45.0 °C(Predicted) |
Density | 1.167 |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly) |
form | Solid |
pka | 13.29±0.20(Predicted) |
color | Off-White to Pale Beige |
LogP | 1.23 at 23℃ and pH6.47 |
Surface tension | 71mN/m at 36.9mg/L and 19℃ |
CAS DataBase Reference | 73942-87-7(CAS DataBase Reference) |
FDA UNII | HV3ZHP3F8A |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | D4824 | 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one >98.0%(GC) | 73942-87-7 | 1g | $72 | 2024-03-01 | Buy |
TCI Chemical | D4824 | 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one >98.0%(GC) | 73942-87-7 | 5g | $285 | 2024-03-01 | Buy |
TRC | D461010 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one | 73942-87-7 | 1g | $80 | 2021-12-16 | Buy |
AK Scientific | J97545 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one | 73942-87-7 | 5g | $77 | 2021-12-16 | Buy |
Chem-Impex | 43244 | 7,8-Dimethoxy-1H-benzo[δ]azepin-2(3H)-one,≥98%(GC) ≥98%(GC) | 73942-87-7 | 1G | $39.29 | 2021-12-16 | Buy |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Chemical Properties,Uses,Production
Uses
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Definition
ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd | +86-010-83386758 +86-18810831598 | jennifer@lianben.com | China | 85 | 58 |
Jiangsu Yutian pharmaceutical Co.,Ltd. | +undefined-0518-86098006 +undefined19851887368 | lvan.hui@jsytsw.com | China | 80 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +8615064153060 | sales01@jndxj.com | China | 291 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-15 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
|
US $50.00 / kg | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. | ||
2023-12-18 | 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one
73942-87-7
|
US $0.00-0.00 / KG | 1KG | 99% | 50000KG | Hebei Kingfiner Technology Development Co.Ltd | ||
2023-11-01 | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
|
US $0.00-0.00 / kg | 0.1kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd |
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
- US $50.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazepine-2-one
73942-87-7
- US $0.00-0.00 / KG
- 99%
- Hebei Kingfiner Technology Development Co.Ltd
- 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
73942-87-7
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
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