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2-(chloromethyl)-4-methylquinazoline

2-(chloromethyl)-4-methylquinazoline structure

CAS No.: 109113-72-6

Chemical Name:: 2-(chloromethyl)-4-methylquinazoline

Synonyms: Quinazoline,2-(chloroMethyl)-4-Methyl-;Linaint-I;Linagliptin INT3;Linagliptin Impurity 67;Linagliptin interMediate A;CHLOROMETHYL)-4-METHYLQUINAZOLINE;2-chloroMethyl-4-Methyl quinaoline;2-(chloromethyl)-4-methylquizoline;Linagliptin 2-Chloromethyl Impurity;2-(chloromethyl)-4-methylquinazolin

CBNumber:: CB71648970

Molecular Formula:: C10H9ClN2

Molecular Weight:: 192.64

MDL Number:: MFCD09807547

MOL File:: 109113-72-6.mol

Last updated:2023-11-29 13:07:42

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2-(chloromethyl)-4-methylquinazoline Properties

Melting point	61.0 to 65.0 °C
Boiling point	240.0±32.0 °C(Predicted)
Density	1.251
vapor pressure	0Pa at 20℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	powder to crystal
pka	1.86±0.50(Predicted)
color	Light yellow to Yellow to Orange
Water Solubility	3.11g/L at 20℃
λmax	318nm(EtOH)(lit.)
InChIKey	UHCUBOJGMLASBY-UHFFFAOYSA-N
LogP	1.9 at 25℃
FDA UNII	KC7BTH55VT

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501

RIDADR

3261

HazardClass

PackingGroup

III

HS Code

2933998090

NFPA 704

	0
3		0

2-(chloromethyl)-4-methylquinazoline price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2928	2-(Chloromethyl)-4-methylquinazoline >98.0%(GC)	109113-72-6	1g	$78	2024-03-01	Buy
TCI Chemical	C2928	2-(Chloromethyl)-4-methylquinazoline >98.0%(GC)	109113-72-6	200mg	$28	2024-03-01	Buy
TRC	C369850	2-(Chloromethyl)-4-methylquinazoline	109113-72-6	2.5g	$95	2021-12-16	Buy
TRC	C369850	2-(Chloromethyl)-4-methylquinazoline	109113-72-6	5g	$155	2021-12-16	Buy
TRC	C369850	2-(Chloromethyl)-4-methylquinazoline	109113-72-6	25g	$400	2021-12-16	Buy

Product number	Packaging	Price	Buy
C2928	1g	$78	Buy
C2928	200mg	$28	Buy
C369850	2.5g	$95	Buy
C369850	5g	$155	Buy
C369850	25g	$400	Buy

2-(chloromethyl)-4-methylquinazoline Chemical Properties,Uses,Production

Chemical Properties

White to yellow powder

Uses

2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1263, 1986 DOI: 10.1002/jhet.5570230458

Flammability and Explosibility

Not classified

Synthesis

Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%

2-(chloromethyl)-4-methylquinazoline synthesis

Synthesis of 2-(chloromethyl)-4-methylquinazoline from 2-Aminoacetophenone and Chloroacetamide

2-(chloromethyl)-4-methylquinazoline Preparation Products And Raw materials

Raw materials

Ro 5-3663 2-Aminoacetophenone

Preparation Products

2-(chloromethyl)-4-methylquinazoline Suppliers

Global( 471)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	228	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Shanghai Joiny Pharmaceutical Co.,LTD	58
Anhui Ruihan Technology Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2-(chloromethyl)-4-methylquinazoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-10	2-(Chloromethyl)-4-methylquinazoline 109113-72-6	US $0.00 / kg	1kg	98%	hundreds of kg	Shanghai Joiny Pharmaceutical Co.,LTD
2024-03-28	2-(chloromethyl)-4-methylquinazoline 109113-72-6	US $0.00 / kg	25kg	98%-99%	Inquiry	PNP Biotech Co. Ltd
2023-11-27	2-(chloromethyl)-4-methylquinazoline 109113-72-6	US $1.00 / kg	1kg	99%	1 ton	Nanjing Fred Technology Co., Ltd

2-(Chloromethyl)-4-methylquinazoline
109113-72-6
US $0.00 / kg
98%
Shanghai Joiny Pharmaceutical Co.,LTD

2-(chloromethyl)-4-methylquinazoline
109113-72-6
US $0.00 / kg
98%-99%
PNP Biotech Co. Ltd

2-(chloromethyl)-4-methylquinazoline
109113-72-6
US $1.00 / kg
99%
Nanjing Fred Technology Co., Ltd

2-(chloromethyl)-4-methylquinazoline Spectrum

2-(chloromethyl)-4-methylquinazoline(109113-72-6)¹HNMR

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2-(chloromethyl)-4-methylquinazoline Linagliptin interMediate A 2-chloroMethyl-4-Methyl quinaoline Linagliptin INT3 Linaint-I 2-(chloromethyl)-4-methylquizoline Linagliptin 2-Chloromethyl Impurity 2-(Chloromethyl)-4-methylquinazoline > 2-(chloromethyl)-4-methylquinazolin CHLOROMETHYL)-4-METHYLQUINAZOLINE 2-(chloromethyl)-4-methylquinazoline ISO 9001：2015 REACH (2-(chloromethyl)-4-methylquinazoline)，2-(chloromethyl)-4-methylquinazoline Linagliptin intermediates，2-(chloromethyl)-4-methylquinazoline Linagliptin Impurity 67 2-(chloromethyl)-4-methylquinazolineQ: What is 2-(chloromethyl)-4-methylquinazoline Q: What is the CAS Number of 2-(chloromethyl)-4-methylquinazoline Q: What is the storage condition of 2-(chloromethyl)-4-methylquinazoline Quinazoline,2-(chloroMethyl)-4-Methyl- Linagliptin Impurity 35(Not Continued,see C4X-110132) 2-(Chloromethyl)-4-Methylquinazoline / Linagliptin Intermediate Linagliptin intermediate Quinazoline, 2-(chloromethyl)-4-methyl- 2-(Chloromethyl)-4-methylquinazoline (2-CMQ) 109113-72-6 109133-72-6 Intermediates 109113-72-6