VALINOMYCIN | 2001-95-8

VALINOMYCIN Properties

Melting point	187-190 °C
alpha	D20 +31.0° (c = 1.6 in benzene)
Boiling point	821.74°C (rough estimate)
Density	1.060
refractive index	1.6400 (estimate)
Flash point	87℃
storage temp.	2-8°C
solubility	DMSO: ≥10 mg/mL
pka	11.32±0.70(Predicted)
form	solid
color	white
optical activity	[α]20/D +32±2°, c = 1.6% in benzene
Water Solubility	Soluble in DMSO at 10mg/ml. Insoluble in water
Merck	13,9976
BRN	78657
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
EWG's Food Scores	1
FDA UNII	N561YS75MN
EPA Substance Registry System	Valinomycin (2001-95-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300+H310

Precautionary statements

P262-P280-P301+P310+P330-P302+P352+P310

Hazard Codes

Xn,T,T+,Xi

Risk Statements

27/28-36/37/38-21/22

Safety Statements

36-45-36/37-28-37/39-26

RIDADR

UN 2811 6.1/PG 1

WGK Germany

3

RTECS

YV9468000

F

10-18-21

TSCA

Yes

HazardClass

6.1(a)

PackingGroup

I

HS Code

29419090

NFPA 704

	0
4		0

VALINOMYCIN price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	60403	Potassium ionophore I Selectophore	2001-95-8	100mg	$495	2024-03-01	Buy
Sigma-Aldrich	676377	Valinomycin A cyclododecadepsi-peptide ionophore antibiotic.	2001-95-8	25mg	$117	2022-05-15	Buy
Alfa Aesar	J62312	Valinomycin, 90+%	2001-95-8	100mg	$290	2024-03-01	Buy
Alfa Aesar	J67410	Valinomycin, 10 mg/ml in DMSO sterile-filtered	2001-95-8	1ml	$63.4	2021-12-16	Buy
Cayman Chemical	10009152	Valinomycin ≥95%	2001-95-8	5mg	$25	2024-03-01	Buy

Product number	Packaging	Price	Buy
60403	100mg	$495	Buy
676377	25mg	$117	Buy
J62312	100mg	$290	Buy
J67410	1ml	$63.4	Buy
10009152	5mg	$25	Buy

VALINOMYCIN Chemical Properties,Uses,Production

Description

Valinomycin (2001-95-8) is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 Valinomycin can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3

Chemical Properties

white crystalline powder

Uses

antibiotic; LD50 (rat, po) 4 mg/kg

Uses

Insecticide, nematocide, Patterson, Wright, US 3520973 (1970 to Am. Cyanamid).

Uses

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta gonizes ET-induced vasoconstriction. Used as insecticide, nematocide.

Uses

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

Uses

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

Definition

ChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.

General Description

Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.

Reactivity Profile

VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

VALINOMYCIN is highly toxic orally.

Fire Hazard

When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.

Biological Activity

Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .

Biochem/physiol Actions

Valinomycin affects the ion transport behavior of mitochondrial systems.

in vitro

valinomycin caused substantial cho cells death within 12 h of treatment. several apoptotic events were identified in valinomycin-treated cho cells, including caspase-3 activation, phosphatidylserine (ps) membrane translocation, and mitochondrial membrane depolarization during the first few hours of treatment. k+ efflux was reduced by elevating extracellular k+ concentrations [2].

in vivo

valinomycin is irritant in the case of eye and skin contact. inhalation of valinomycin can cause breathing disturbances and even loss of conscious. lethal doses (ld50) for mouse and rabbit is 2.5 mg/kg and 5 mg/kg respectively. valinomycin also shows to provoke lots of chronic effects, including damage of the central and peripheral nervous system, eyes, lens and cornea [1].

storage

Store at -20°C

Purification Methods

Recrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]

References

1) Pressman, (1976) Biological applications of ionophores; Annu. Rev. Biochem., 45 501 2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification; Cell Death Diff., 5 214 3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc. Funct., 22 555

VALINOMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

VALINOMYCIN Suppliers

Global( 206)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3586	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
career henan chemical co	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58

View Lastest Price from VALINOMYCIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-08-30	VALINOMYCIN 2001-95-8	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2021-06-24	VALINOMYCIN USP/EP/BP 2001-95-8	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2021-05-25	VALINOMYCIN 2001-95-8	US $1.00 / PCS	1KG	99%	10 mt	Hebei Guanlang Biotechnology Co., Ltd.

VALINOMYCIN
2001-95-8
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

VALINOMYCIN USP/EP/BP
2001-95-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

VALINOMYCIN
2001-95-8
US $1.00 / PCS
99%
Hebei Guanlang Biotechnology Co., Ltd.

VALINOMYCIN Spectrum

VALINOMYCIN(2001-95-8)¹HNMR

2001-95-8(VALINOMYCIN)Related Search:

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ISOPROPYL PROPIONATE 2-(ISOPROPYLAMINO)ETHANOL VALINOMYCIN

1of4

1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11, 14,17,20,23,26,29,32,35-dodecone,12,24,36-trimetyl-3,6,9,15,18,21,27,30,33-non akis(1-methylethyl)-[qr] aleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l antibioticn-329b cyclic(d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisov nsc122023 nsc122023[qr] valinomicin[qr] ValinoMycin, froM StreptoMyces fulvissiMus -valyl)[qr] VALINOMYCIN VALINOMYCIN, STREPTOMYCES FULVISSIMUS POTASSIUM IONOPHORE I CYCLO[-L-VAL-D-HYLVA-D-VAL-L-LAC-]3 CYCLO(LAC-VAL-D-HIV-D-VAL-LAC-VAL-D-HIV-D-VAL-) Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid VALINOMYCIN >94% PURITY VALINOMYCIN READY MADE SOLUTION VALINOMYCIN 99% Valinomycin,90% Valinomycin,96% Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl) VALINOMYCINRESEARCH GRADE Potassium ionophore I,Valinomycin Valinomycin,Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid 1Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α- hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl) 3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-triMethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone VALINOMYCIN,CRYSTAL Valinomycin, ≥98%(TLC),≥95%(HPLC),solid Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem Valinomycin, 97%, from Streptomyces fulvissimus VALINOMYCIN USP/EP/BP Valinomycin (NSC-122023) valinomicin valamycin 2001-95-8 C54H90N6O18 BioChemical Analytical Chromatography Product Catalog Antibiotics A to Z Antibiotics Antibiotics T-Z Ionophores Potentiometric for ISE Ion Sensor Materials antibiotic Agro-Products Inhibitors Peptides