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Tegaserod maleate

CAS No.
189188-57-6
Chemical Name:
Tegaserod maleate
Synonyms
ZELMAC;HTF 919;ZelnorM;Tegibs 6;Toromifene;SDZ-HTF-919;TegaserodMalate;TegastrodMaleate;TEGASEROD MALEATE;Tegaserol Maleate
CBNumber:
CB7225422
Molecular Formula:
C20H27N5O5
Molecular Weight:
417.46
MDL Number:
MFCD04116201
MOL File:
189188-57-6.mol
MSDS File:
SDS
Last updated:2023-07-27 17:50:07

Tegaserod maleate Properties

Melting point 180-183°C
storage temp. 2-8°C
solubility Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Sparingly)
form powder
color white to beige
CAS DataBase Reference 189188-57-6(CAS DataBase Reference)
FDA UNII E5XNT3RF5A

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H400-H410-H317
Precautionary statements  P273-P391-P501-P273-P391-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501

Tegaserod maleate price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1504 Tegaserod maleate ≥98% (HPLC) 189188-57-6 10MG $120 2024-03-01 Buy
Sigma-Aldrich SML1504 Tegaserod maleate ≥98% (HPLC) 189188-57-6 50MG $490 2024-03-01 Buy
Cayman Chemical 14692 Tegaserod (maleate) ≥98% 189188-57-6 5mg $73 2024-03-01 Buy
Cayman Chemical 14692 Tegaserod (maleate) ≥98% 189188-57-6 10mg $116 2024-03-01 Buy
Cayman Chemical 14692 Tegaserod (maleate) ≥98% 189188-57-6 25mg $217 2024-03-01 Buy
Product number Packaging Price Buy
SML1504 10MG $120 Buy
SML1504 50MG $490 Buy
14692 5mg $73 Buy
14692 10mg $116 Buy
14692 25mg $217 Buy

Tegaserod maleate Chemical Properties,Uses,Production

Description

Tegaserod maleate was launched as a new oral treatment of constipationpredominant or diarrhea-predominant irritable bowel syndrome. It can be prepared by condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine. Tegaserod is a selective partial agonist of the excitatory 5-HT4 receptor (K1 = 18 nM in human caudate membranes) and was designed from the endogenous full agonist, seretonin. In the model of potentiation of the electrically stimulated contraction of longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic activity compared with serotonin. However, it appeared more potent in several studies on intestinal mucosal tissue from various species including man. A lack of effect on the QTc interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also clinically developed for the treatment of other functional GI disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD).

Chemical Properties

White Powder

Originator

Novartis (Switzerland)

Uses

Tegaserod is a gastroproeinetic used in the treatment of irritable bowel syndrome. A selective serotonin 5HT4-receptor partial agonist.

Uses

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

brand name

Zelnorm (Novartis);Zelmac.

Biochem/physiol Actions

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.

storage

+4°C

Tegaserod maleate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 231)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290 1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58

View Lastest Price from Tegaserod maleate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tegaserod maleate pictures 2023-07-28 Tegaserod maleate
189188-57-6
US $10.00 / kg 1kg 99% 1000tons Henan Bao Enluo International TradeCo.,LTD
Tegaserod maleate pictures 2022-10-11 Tegaserod maleate
189188-57-6
US $1.00 / kg 1kg 99% 5000 Ton Hebei Duling International Trade Co. LTD
Tegaserod maleate pictures 2022-02-25 Tegaserod maleate
189188-57-6
US $88.00 / KG 1KG 99% 1 ton Hong Kong Tiansheng New Material Trading Co., Ltd
  • Tegaserod maleate pictures
  • Tegaserod maleate
    189188-57-6
  • US $10.00 / kg
  • 99%
  • Henan Bao Enluo International TradeCo.,LTD
  • Tegaserod maleate pictures
  • Tegaserod maleate
    189188-57-6
  • US $1.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
  • Tegaserod maleate pictures
  • Tegaserod maleate
    189188-57-6
  • US $88.00 / KG
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
SDZ-HTF-919 TEGASEROD MALEATE ZELMAC 2-[(5-METHOXY-1H-INDOL-3-YL)METHYLENE]-N-PENTYLHYDRAZINECARBOXIMIDAMIDE, MALEATE 2-[(5-methoxy-1h-indole-3-yl)methylene]-n-pentylcarbazimidamide hydrogen maleate TegaserodMalate TegastrodMaleate SDZ-HTF-919, Zelmac, 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide, Maleate Toromifene Tegaserod Hydrogen Maleate 2-[(5-Methoxy-1H-indol-3-yl)Methylene]-N-pentylhydrazinecarboxiMidaMide (2Z)-2-Butenedioate HTF 919 Tegibs 6 ZelnorM 1-[(5-methoxy-3-indolylidene)methylamino]-2-pentylguanidine ZELNORM;SDZ-HTF-919;HTF-919;ZELMAC Tegaserol Maleate Tegaserod maleate USP/EP/BP Tegaserod maleateQ: What is Tegaserod maleate Q: What is the CAS Number of Tegaserod maleate Q: What is the storage condition of Tegaserod maleate Q: What are the applications of Tegaserod maleate Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1) 2-((5-Methoxy-1H-indol-3-yl)methylene)-N-pentylhydrazine-1-carboximidamide maleate 189188-57-6 C16H23ON5C4H4O4 C16H23N5OC4H4O4C20H27N5O5 C16H23N5OC4H4O4 C20H27N5O5 C16H23N5OC4H4O4C20H Chiral Compound Intermediates & Fine Chemicals Pharmaceuticals Tegaserod Active Pharmaceutical Ingredients