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3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide structure

CAS No.: 860352-01-8

Chemical Name:: 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide

Synonyms: CS-314;AZD 7762;White solid;AZD7762; AZD-7762;AZD-7762 Chk Inhibitor;1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea;(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide;5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide;3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide

CBNumber:: CB72473926

Molecular Formula:: C17H19FN4O2S

Molecular Weight:: 362.42

MDL Number:: MFCD12406007

MOL File:: 860352-01-8.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Properties

Boiling point	547.6±50.0 °C(Predicted)
Density	1.38
storage temp.	-20°
solubility	Soluble in DMSO (up to at least 25 mg/ml).
form	solid
pka	9.06±0.20(Predicted)
color	Yellow or brown
Stability	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
FDA UNII	5D822Y3L1H

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Danger

Hazard statements

H318-H302

Precautionary statements

P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310

NFPA 704

	0
3		0

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11491	AZD 7762 ≥98%	860352-01-8	1mg	$25	2024-03-01	Buy
Cayman Chemical	11491	AZD 7762 ≥98%	860352-01-8	5mg	$56	2024-03-01	Buy
Cayman Chemical	11491	AZD 7762 ≥98%	860352-01-8	10mg	$100	2024-03-01	Buy
Cayman Chemical	11491	AZD 7762 ≥98%	860352-01-8	25mg	$188	2024-03-01	Buy
TRC	A808125	AZD7762	860352-01-8	100mg	$710	2021-12-16	Buy

Product number	Packaging	Price	Buy
11491	1mg	$25	Buy
11491	5mg	$56	Buy
11491	10mg	$100	Buy
11491	25mg	$188	Buy
A808125	100mg	$710	Buy

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Chemical Properties,Uses,Production

Description

Actively proliferating cells experience blocks at certain checkpoints in the cell cycle when DNA damage is detected. These checkpoints allow for DNA damage repair before further cell cycle progression. Targeting signaling pathways to selectively inhibit repair at these checkpoints in tumor cells is of considerable interest to cancer therapeutics. AZD 7762 selectively inhibits the activity of checkpoint kinases (Chk) 1 and Chk2 (IC₅₀s = 5 nM) by competitively and reversibly binding their respective ATP-binding sites (K_i = 3.6 nM for Chk1). AZD 7762 abrogates DNA damage-induced S and G₂ checkpoints with an EC₅₀ value of 10 nM and potentiates the efficacy of DNA-damage repair prohibitive agents, gemcitabine and topotecan, both in vitro and in various tumor xenografts by modulating downstream checkpoint pathway proteins.

Uses

AZD 7762 is studied as an cancer therapeutic agent due to its selective inhibitory activities towards checkpoint kinases, chk1 and chk2 by reversibly binding their respective ATP-binding sites within tumor cells. Recent research has also indicated AZD 7762 to possess enhancing effects towards other chk1 inhibitor lethality in glioblastoma cells.

Definition

ChEBI: 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-3-piperidinyl]-2-thiophenecarboxamide is an aromatic amide and a member of thiophenes.

References

1) Zabludoff?et al.?(2008)?AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies; Mol. Cancer Ther.?7?2955 2) Mitchell?et al.?(2010)?In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762; Clin. Cancer Res.?16?2076 3) Morgan?et al. (2010)?Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair; Cancer Res.?70?49721 4) Lei?et al.?(2018)?Chk1 inhibitors overcome imatinib resistance in chronic myeloid leukemia cells; Leuk. Res.?64?17 5) Ahmad?et al. (2015)?Identification of Ponatinib and Other Known Kinase Inhibitors with Potent MEKK2 Inhibitory Activity;?Biochem. Biophys. Res. Commun.?463?888 6) Park?et al.?(2018)?Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn; Biochem. Pharmacol.?154?270

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-06	3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 860352-01-8	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co
	2020-03-06	3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 860352-01-8	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
860352-01-8
US $1.00 / KG
99%
Career Henan Chemical Co

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
860352-01-8
US $1.00 / KG
99%
Career Henan Chemical Co

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Spectrum

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide(860352-01-8)MS 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide(860352-01-8)¹HNMR

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Olaparib

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3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide AZD 7762 White solid 1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide AZD 7762 AZD 7762 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide AZD7762; AZD-7762 CS-314 2-Thiophenecarboxamide, 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl- 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide USP/EP/BP (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide hydrochloride 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide AZD-7762 Chk Inhibitor 860352-01-8 860325-01-8 api Inhibitors