MK-2206 2HCl
- CAS No.
- 1032350-13-2
- Chemical Name:
- MK-2206 2HCl
- Synonyms
- MK-2206;CS-260;MK-2206 2HCl;MK-2206 HCl salt;MK-2206 2HCL;MK2206;Benodanil Impurity 9;MK-2206 2HCl USP/EP/BP;MK-2206 Dihydrochloride;MK 2206 (hydrochloride);MK 2206 2HCL;MK2206 2HCL
- CBNumber:
- CB72489901
- Molecular Formula:
- C25H22ClN5O
- Molecular Weight:
- 443.94
- MDL Number:
- MFCD14584463
- MOL File:
- 1032350-13-2.mol
| Melting point | >255°C (dec.) |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml with warming) |
| form | Yellow powder. |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | Q34I3E28IO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
MK-2206 2HCl price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11593 | MK-2206 (hydrochloride) ≥98% | 1032350-13-2 | 1mg | $43 | 2024-03-01 | Buy |
| Cayman Chemical | 11593 | MK-2206 (hydrochloride) ≥98% | 1032350-13-2 | 5mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 11593 | MK-2206 (hydrochloride) ≥98% | 1032350-13-2 | 10mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 11593 | MK-2206 (hydrochloride) ≥98% | 1032350-13-2 | 25mg | $137 | 2024-03-01 | Buy |
| Usbiological | M4095-40 | MK-2206 | 1032350-13-2 | 500ug | $316 | 2021-12-16 | Buy |
MK-2206 2HCl Chemical Properties,Uses,Production
Description
MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the?in vitro?and?in vivo?antitumor efficacy of several standard chemotherapeutic agents.1?It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2?MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3
Uses
AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.
Uses
A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.
Uses
AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vi vo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents.
target
Akt1
storage
-20°C
References
1) Hirai?et al.?(2010),?MK-2206, an Allosteric Akt inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular targeted Drugs In vitro and In vivo; Mol. Cancer Ther.?9?1956 2) Lai?et al.?(2012),?A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle; Biochem. J.?447?137 3) Jiao?et al.?(2013),?MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death; Mol. Cell Biochem.?382?217
MK-2206 2HCl Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
View Lastest Price from MK-2206 2HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-07 | MK-2206 2HCl
1032350-13-2
|
US $30.00 / kg | 1kg | 99% | 1000t/year | Anhui Ruihan Technology Co., Ltd | |
 |
2023-01-31 | MK-2206 2HCl
1032350-13-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2019-07-06 | MK-2206 2HCl
1032350-13-2
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- MK-2206 2HCl
1032350-13-2
- US $30.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
-
- MK-2206 2HCl
1032350-13-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- MK-2206 2HCl
1032350-13-2
- US $2.00 / kg
- 99%
- Career Henan Chemical Co