ChemicalBook >> CAS DataBase List >>ML 254
ML 254
- CAS No.
- 1428630-86-7
- Chemical Name:
- ML 254
- Synonyms
- ML 254;5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide;5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyloxetan-3-yl)pyridine-2-carboxamide;2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-;ML 254,inhibit,ML254,ML-254,Inhibitor,Metabotropic glutamate receptors,mGluR,Schizophrenia
- CBNumber:
- CB72716289
- Molecular Formula:
- C18H15FN2O2
- Molecular Weight:
- 310.32
- MDL Number:
- MFCD28386364
- MOL File:
- 1428630-86-7.mol
Last updated:2023-09-20 16:43:00
ML 254 price
ML 254 Chemical Properties,Uses,Production
Description
ML-254, also known as VU0430644; is Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents. Preliminary experiments at a single dose in an in vivo model of psychosis using ML254 demonstrates a robust reversal of amphetamine induced hyperlocomotion. ML254 will serve as a significant pure-PAM tool compound for the field with potential for studies within in vivo paradigms. Structure activity relationship (SAR) and characterization of ML254 are described.
ML 254 Preparation Products And Raw materials
Raw materials
Preparation Products
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| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
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| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
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ML 254
5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyloxetan-3-yl)pyridine-2-carboxamide
5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide
2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-
ML 254,inhibit,ML254,ML-254,Inhibitor,Metabotropic glutamate receptors,mGluR,Schizophrenia
1428630-86-7