Estradiol
- CAS No.
- 57-91-0
- Chemical Name:
- Estradiol
- Synonyms
- α-Estradiol;BETA-ESTRADIOL;B-ESTRADIOL;ALPHA-ESTRADIOL;17B-ESTRADIOL;Alfatradiol;17α-estradiol;17A-ESTRADIOL;17ALPHA-ESTRADIOL;Estradiol EP Impurity B
- CBNumber:
- CB7289534
- Molecular Formula:
- C18H24O2
- Molecular Weight:
- 272.39
- MDL Number:
- MFCD00064144
- MOL File:
- 57-91-0.mol
| Melting point | 176-180 °C(lit.) |
|---|---|
| Boiling point | 355.44°C (rough estimate) |
| alpha | D20 +53 to +56° (c = 0.9 in dioxane) |
| Density | 1.0708 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: 50 mg/mL, clear, colorless |
| form | powder |
| pka | 10.27±0.60(Predicted) |
| color | white with slight yellow |
| Water Solubility | 3.9mg/L(25 ºC) |
| Merck | 14,3704 |
| CAS DataBase Reference | 57-91-0(CAS DataBase Reference) |
| FDA UNII | 3VQ38D63M7 |
| Proposition 65 List | Estradiol 17B |
| NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| EPA Substance Registry System | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H341-H351-H360F-H362-H410 |
| Precautionary statements | P201-P202-P260-P263-P273-P308+P313 |
| Hazard Codes | T,Xn |
| Risk Statements | 45-48-40 |
| Safety Statements | 53-45-24/25-22 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | KG3750000 |
| F | 8-10 |
| HS Code | 29372390 |
Estradiol price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E8750 | α-Estradiol powder, ≥98% (TLC) | 57-91-0 | 1g | $449.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 46542 | α-Estradiol VETRANAL | 57-91-0 | 100mg | $156 | 2024-03-01 | Buy |
| Cayman Chemical | 20776 | 17α-Estradiol ≥98% | 57-91-0 | 50mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 20776 | 17α-Estradiol ≥98% | 57-91-0 | 100mg | $76 | 2024-03-01 | Buy |
| Sigma-Aldrich | E8750 | α-Estradiol powder, ≥98% (TLC) | 57-91-0 | 100mg | $120 | 2024-03-01 | Buy |
Estradiol Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Definition
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biological Activity
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
target
Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor
storage
Room temperature
Purification Methods
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.
Estradiol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | ada@sh-teruiop.com | China | 892 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 524 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | +8615139564871 | wrjmoon2000@163.com | China | 354 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
View Lastest Price from Estradiol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | Estradiol
57-91-0
|
US $9.90 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | |
 |
2024-04-12 | Estradiol
57-91-0
|
US $3.00-1.00 / kg | 1kg | 99.9% | 10 tons | Shanghai Aosiris new Material Technology Co., LTD | |
 |
2024-04-08 | 17a-estradiol
57-91-0
|
US $100.00 / kg | 1kg | 99.9% | 20tons | Hong Kong Excellence Biotechnology Co., Ltd. |
-
- Estradiol
57-91-0
- US $9.90 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
-
- Estradiol
57-91-0
- US $3.00-1.00 / kg
- 99.9%
- Shanghai Aosiris new Material Technology Co., LTD
-
- 17a-estradiol
57-91-0
- US $100.00 / kg
- 99.9%
- Hong Kong Excellence Biotechnology Co., Ltd.
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