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SHA 68

CAS No.
847553-89-3
Chemical Name:
SHA 68
Synonyms
SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-
CBNumber:
CB73037532
Molecular Formula:
C26H24FN3O3
Molecular Weight:
445.49
MDL Number:
MFCD22683843
MOL File:
847553-89-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

SHA 68 Properties

Boiling point 727.8±60.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form A crystalline solid
pka 13.32±0.40(Predicted)

SHA 68 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1459 SHA 68 ≥98% (HPLC) 847553-89-3 5MG $91.9 2024-03-01 Buy
Sigma-Aldrich SML1459 SHA 68 ≥98% (HPLC) 847553-89-3 25MG $462 2024-03-01 Buy
Cayman Chemical 21512 SHA-68 ≥95% 847553-89-3 1mg $32 2024-03-01 Buy
Cayman Chemical 21512 SHA-68 ≥95% 847553-89-3 5mg $88 2024-03-01 Buy
Cayman Chemical 21512 SHA-68 ≥95% 847553-89-3 10mg $160 2024-03-01 Buy
Product number Packaging Price Buy
SML1459 5MG $91.9 Buy
SML1459 25MG $462 Buy
21512 1mg $32 Buy
21512 5mg $88 Buy
21512 10mg $160 Buy

SHA 68 Chemical Properties,Uses,Production

Description

SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.

Uses

SHA 68 is a selective neuropeptide S antagonist.

storage

Store at +4°C

SHA 68 Preparation Products And Raw materials

Raw materials

Preparation Products

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847553-89-3(SHA 68)Related Search:

SHA 68 N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide 3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl- 847553-89-3