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NCT-501

CAS No.
1802088-50-1
Chemical Name:
NCT-501
Synonyms
CS-2069;NCT-501;NCT-501 >=98% (HPLC);Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-
CBNumber:
CB73043300
Molecular Formula:
C21H32N6O3
Molecular Weight:
416.52
MDL Number:
MFCD29472261
MOL File:
1802088-50-1.mol
Last updated:2023-05-21 10:59:17

NCT-501 Properties

Boiling point 627.3±65.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥20.85 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥11 mg/mL in EtOH
form solid
pka 5.26±0.10(Predicted)

NCT-501 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21162 NCT-501 ≥98% 1802088-50-1 1mg $57 2024-03-01 Buy
Cayman Chemical 21162 NCT-501 ≥98% 1802088-50-1 5mg $233 2024-03-01 Buy
Cayman Chemical 21162 NCT-501 ≥98% 1802088-50-1 10mg $412 2024-03-01 Buy
Cayman Chemical 21162 NCT-501 ≥98% 1802088-50-1 25mg $887 2024-03-01 Buy
AK Scientific 4502EC 8-[[4-(Cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione 1802088-50-1 25mg $1086 2021-12-16 Buy
Product number Packaging Price Buy
21162 1mg $57 Buy
21162 5mg $233 Buy
21162 10mg $412 Buy
21162 25mg $887 Buy
4502EC 25mg $1086 Buy

NCT-501 Chemical Properties,Uses,Production

Description

NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.

References

yang s m, yasgar a, miller b, et al. discovery of nct-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1)[j]. journal of medicinal chemistry, 2015, 58(15): 5967-5978.

NCT-501 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 75)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4648 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4121 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 318 55

NCT-501 Spectrum

NCT-501 CS-2069 1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)- NCT-501 >=98% (HPLC) Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501 8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione 1802088-50-1