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GS 9451

GS 9451 structure

CAS No.: 1098189-15-1

Chemical Name:: GS 9451

Synonyms: Vedroprevir;OTXAMWFYPMNDME-FQQWJMKMSA-N;Cyclopropanecarboxylic acid, N-[[(1α,3β,5α)-bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-, (1R,2R)-;(1R,2R)-N-[[(1alpha,3beta,5alpha)-Bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-cyclopropanecarboxylic acid

CBNumber:: CB73052043

Molecular Formula:: C45H60ClN7O9S

Molecular Weight:: 910.53

MDL Number:: MFCD27987929

MOL File:: 1098189-15-1.mol

Last updated:2022-12-21 16:56:50

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GS 9451 Properties

Density	1.38±0.1 g/cm3(Predicted)
pka	5.10±0.50(Predicted)
FDA UNII	KGD958X2B9

GS 9451 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	V105400	Vedroprevir	1098189-15-1	10mg	$30250	2021-12-16	Buy
TRC	V105400	Vedroprevir	1098189-15-1	25mg	$35750	2021-12-16	Buy

Product number	Packaging	Price	Buy
V105400	10mg	$30250	Buy
V105400	25mg	$35750	Buy

GS 9451 Chemical Properties,Uses,Production

Uses

Vedroprevir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.

GS 9451 synthesis

Synthesis of GS 9451 from Cyclopropanecarboxyl?ic acid, N-?[[(1α,?3β,?5α)?-?bicyclo[3.1.0]?hex-?3-?yloxy]?carbonyl]?-?3-?methyl-?L-?valyl-?(4R)?-?4-?[[8-?chloro-?2-?[2-?[(1-?methylethyl)?amino]?-?4-?thiazolyl]?-?7-?[2-?(4-?morpholinyl)?ethoxy]?-?4-?quinolinyl]?oxy]?-?L-?prolyl-?1-?amino-?2-?ethyl-?, methyl ester, (1R,?2R)?-

GS 9451 Preparation Products And Raw materials

Raw materials

Cyclopropanecarboxyl?ic acid, N-?[[(1α,?3β,?5α)?-?bicyclo[3.1.0]?hex-?3-?yloxy]?carbonyl]?-?3-?methyl-?L-?valyl-?(4R)?-?4-?[[8-?chloro-?2-?[2-?[(1-?methylethyl)?amino]?-?4-?thiazolyl]?-?7-?[2-?(4-?morpholinyl)?ethoxy]?-?4-?quinolinyl]?oxy]?-?L-?prolyl-?1-?amino-?2-?ethyl-?, methyl ester, (1R,?2R)?- Cyclopropanecarboxyl?ic acid, N-?[[(1α,?3β,?5α)?-?bicyclo[3.1.0]?hex-?3-?yloxy]?carbonyl]?-?3-?methyl-?L-?valyl-?(4R)?-?4-?[[8-?chloro-?7-?(2,?2-?dimethoxyethoxy)?-?2-?[2-?[(1-?methylethyl)?amino]?-?4-?thiazolyl]?-?4-?quinolinyl]?oxy]?-?L-?prolyl-?1-?amino-?2-?ethyl-?, methyl ester, (1R,?2R)?- Cyclopropanecarboxyl?ic acid, N-?[(1,?1-?dimethylethoxy)?carbonyl]?-?3-?methyl-?L-?valyl-?(4S)?-?4-?[[(4-?bromophenyl)?sulfonyl]?oxy]?-?L-?prolyl-?1-?amino-?2-?ethyl-?, methyl ester, (1R,?2R)?- 4-?Quinolinol, 8-?chloro-?7-?(2,?2-?dimethoxyethoxy)?-?2-?[2-?[(1-?methylethyl)?amino]?-?4-?thiazolyl]?- Ethanone, 1-?[2-?amino-?3-?chloro-?4-?(2,?2-?dimethoxyethoxy)?phenyl]?-

Ethanone, 1-?(2-?amino-?3-?chloro-?4-?hydroxyphenyl)?- Carbonic acid, (1α,?3β,?5α)?-?bicyclo[3.1.0]?hex-?3-?yl (2,?5-?dioxo-?1-?pyrrolidinyl) ester L-?Proline, N-?[(1,?1-?dimethylethoxy)?carbonyl]?-?3-?methyl-?L-?valyl-?4-?[[(4-?bromophenyl)?sulfonyl]?oxy]?-?, (4S)?- L-Proline, 4-[[(4-bromophenyl)sulfonyl]oxy]-, methyl ester, hydrochloride (1:1), (4S)- L-?Proline, N-?[(1,?1-?dimethylethoxy)?carbonyl]?-?3-?methyl-?L-?valyl-?4-?[[(4-?bromophenyl)?sulfonyl]?oxy]?-?, methyl ester, (4S)?-

CIS-BICYCLO[3.1.0]HEXAN-3-OL Cyclopropanecarboxyl?ic acid, N-?[[(1α,?3β,?5α)?-?bicyclo[3.1.0]?hex-?3-?yloxy]?carbonyl]?-?3-?methyl-?L-?valyl-?(4S)?-?4-?[[(4-?bromophenyl)?sulfonyl]?oxy]?-?L-?prolyl-?1-?amino-?2-?ethyl-?, methyl ester, (1R,?2R)?- Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-

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Preparation Products

GS 9451 Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Han-Xiang Chemical Co., Ltd.	15971444841	amber@biochempartner.com	China	3063	58
Taizhou Crene Biotechnology Co. Ltd.	0576-88813233 13396860566	sales@pharm-intermediates.com	China	2013	58
Hubei Xinyang Medical Technology Co., Ltd	15347293736 15347293736	2853117764@qq.com	China	8594	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Han-Xiang Chemical Co., Ltd.	58
Taizhou Crene Biotechnology Co. Ltd.	58
Hubei Xinyang Medical Technology Co., Ltd	58
Energy Chemical	58

(1R,2R)-N-[[(1alpha,3beta,5alpha)-Bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-cyclopropanecarboxylic acid Vedroprevir OTXAMWFYPMNDME-FQQWJMKMSA-N Cyclopropanecarboxylic acid, N-[[(1α,3β,5α)-bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-, (1R,2R)- 1098189-15-1 C45H60ClN7O9S