CHIR-99021 (monohydrochloride)
- CAS No.
- 1797989-42-4
- Chemical Name:
- CHIR-99021 (monohydrochloride)
- Synonyms
- CT99021) HCl;CHIR-99012 HCl;CHIR99021; CHIR 99021;Laduviglusib (CHIR-99021;SCQDMKUZHIGAIB-UHFFFAOYSA-O;CT-99021 monohydrochloride);Laduviglusib (CHIR-99021) HCl;Laduviglusib monohydrochloride;CHIR-99021 (monohydrochloride);CHIR-99021 monohydrochloride (CT99021 monohydrochloride
- CBNumber:
- CB73152077
- Molecular Formula:
- C22H19Cl3N8
- Molecular Weight:
- 501.8
- MDL Number:
- MFCD30489757
- MOL File:
- 1797989-42-4.mol
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
|---|---|
| solubility | ≥25.1 mg/mL in DMSO; ≥4.23 mg/mL in H2O; ≥4.83 mg/mL in EtOH |
| form | solid |
| FDA UNII | 5AW8G37ZX5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
CHIR-99021 (monohydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C292150 | CHIR-99021Hydrochloride | 1797989-42-4 | 100mg | $1390 | 2021-12-16 | Buy |
| ChemScene | CS-5969 | CHIR-99021(monohydrochloride) 99.93% | 1797989-42-4 | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-5969 | CHIR-99021(monohydrochloride) 99.93% | 1797989-42-4 | 10mg | $110 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BC162488 | CHIR 99021 hydrochloride | 1797989-42-4 | 10mg | $125 | 2021-12-16 | Buy |
| ApexBio Technology | A8396 | CHIR-99021(CT99021)HCl | 1797989-42-4 | 25mg | $210 | 2021-12-16 | Buy |
CHIR-99021 (monohydrochloride) Chemical Properties,Uses,Production
Uses
CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. GSK-3α/β inhibitor
Biological Activity
chir-99021 is a highly specific glycogen synthase kinase-3 (gsk-3) inhibitor which can inhibit both isoforms with ic50 of 10 nm (gsk-3α) and 6.7 nm (gsk-3β).chir-99021 was proved to promote self-renewal and maintain pluripotency of both b6 and balb/c es cells via stabilizing the downstream effectors like c-myc and β -catenin[1]. in j1 mesc cells, chir-99021 played an important role in maintaining the colony morphology as well as the self-renewal when combined with leukemia inhibitory factor (lif). chir-99021 has shown to regulate multiple signaling pathways which involve wnt/β-catenin, tgf-β, nodal and mapk, and the expression of epigenetic regulatory genes like dnmt3l[2].chir-99021 has been demonstrated to promote dn3 thymocytes proliferation and differentiation in the absence of pre-tcr signaling, notch1 signaling or cxcl12[3]. however, study has also found that higher concentration (10 μm but not 1 μm or 3 μm) of chir99021 might selectively inhibit differentiation by activating il-7 signaling pathway[3].
References
1. ye s1, tan l, yang r, fang b, qu s, schulze en, song h, ying q, li p. pleiotropy of glycogen synthase kinase-3 inhibition by chir99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. plos one. 2012;7(4):e35892.2. wu y1, ai z, yao k, cao l, du j, shi x, guo z, zhang y. chir99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding rna expression. exp cell res. 20133. plos one. 2013;8(3):e58501. doi: 10.1371/journal.pone.0058501. epub 2013 mar 20. schroeder jh1, bell ls, janas ml, turner m. pharmacological inhibition of glycogen synthase kinase 3 regulates t cell development in vitro. plos one. 2013;8(3):e58501.
CHIR-99021 (monohydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
CHIR-99021 (monohydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |