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HJC0197

CAS No.
1383539-73-8
Chemical Name:
HJC0197
Synonyms
HJC0197;HJC 0197 (HJC0197);6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
CBNumber:
CB73152628
Molecular Formula:
C19H21N3OS
Molecular Weight:
339.45
MDL Number:
MFCD27966183
MOL File:
1383539-73-8.mol
Last updated:2024-10-28 16:48:35

HJC0197 Properties

solubility DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
form A crystalline solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
2 0

HJC0197 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19092 HJC0197 ≥98% 1383539-73-8 1mg $37 2024-03-01 Buy
Cayman Chemical 19092 HJC0197 ≥98% 1383539-73-8 5mg $169 2024-03-01 Buy
Cayman Chemical 19092 HJC0197 ≥98% 1383539-73-8 10mg $283 2024-03-01 Buy
ApexBio Technology C3387 HJC0197 1383539-73-8 10mg $321 2021-12-16 Buy
ApexBio Technology C3387 HJC0197 1383539-73-8 5mg $192 2021-12-16 Buy
Product number Packaging Price Buy
19092 1mg $37 Buy
19092 5mg $169 Buy
19092 10mg $283 Buy
C3387 10mg $321 Buy
C3387 5mg $192 Buy

HJC0197 Chemical Properties,Uses,Production

Description

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.

HJC0197 Preparation Products And Raw materials

Raw materials

Preparation Products

HJC0197 Suppliers

Global( 31)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58
Henan Alfa Chemical Co., Ltd
+86-18339805032; +8618339805032 alfa4@alfachem.cn China 13227 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4456 55
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 423 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 27313 60

View Lastest Price from HJC0197 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HJC0197 pictures 2024-10-28 HJC0197
1383539-73-8
US $49.00-137.00 / mg 98.05% 10g TargetMol Chemicals Inc.
  • HJC0197 pictures
  • HJC0197
    1383539-73-8
  • US $49.00-137.00 / mg
  • 98.05%
  • TargetMol Chemicals Inc.

HJC0197 Spectrum

HJC0197 5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo- HJC 0197 (HJC0197) HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor 6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile 1383539-73-8