ChemicalBook >> CAS DataBase List >>HJC0197
HJC0197
- CAS No.
- 1383539-73-8
- Chemical Name:
- HJC0197
- Synonyms
- HJC0197;HJC 0197 (HJC0197);6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
- CBNumber:
- CB73152628
- Molecular Formula:
- C19H21N3OS
- Molecular Weight:
- 339.45
- MDL Number:
- MFCD27966183
- MOL File:
- 1383539-73-8.mol
Last updated:2024-10-28 16:48:35
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
HJC0197 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19092 | HJC0197 ≥98% | 1383539-73-8 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19092 | HJC0197 ≥98% | 1383539-73-8 | 5mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 19092 | HJC0197 ≥98% | 1383539-73-8 | 10mg | $283 | 2024-03-01 | Buy |
| ApexBio Technology | C3387 | HJC0197 | 1383539-73-8 | 10mg | $321 | 2021-12-16 | Buy |
| ApexBio Technology | C3387 | HJC0197 | 1383539-73-8 | 5mg | $192 | 2021-12-16 | Buy |
HJC0197 Chemical Properties,Uses,Production
Description
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.
HJC0197 Preparation Products And Raw materials
Raw materials
Preparation Products
HJC0197 Suppliers
Global( 31)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32024 | 58 |
| Henan Alfa Chemical Co., Ltd | +86-18339805032; +8618339805032 | alfa4@alfachem.cn | China | 13227 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4456 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 423 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27313 | 60 |
HJC0197
5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-
HJC 0197
(HJC0197)
HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor
6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile
1383539-73-8