1,4-Naphthoquinone

1,4-Naphthoquinone Properties

Melting point	119-122 °C(lit.)
Boiling point	243.22°C (rough estimate)
Density	1,42 g/cm³
vapor pressure	<1 hPa (50 °C)
refractive index	1.5300 (estimate)
Flash point	141 °C
storage temp.	Store below +30°C.
solubility	0.09g/l
form	Powder
color	Khaki
PH	6.1 (10g/l, H2O, 20℃)
Water Solubility	insoluble
Merck	14,6395
BRN	878524
Stability	Stable. Incompatible with strong reducing agents, strong oxidizing agents.
InChIKey	FRASJONUBLZVQX-UHFFFAOYSA-N
LogP	1.71-1.77 at 25℃
CAS DataBase Reference	130-15-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	RBF5ZU7R7K
NIST Chemistry Reference	1,4-Naphthalenedione(130-15-4)
EPA Substance Registry System	1,4-Naphthoquinone (130-15-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06,GHS09

Signal word

Danger

Hazard statements

H301+H311-H314-H317-H330-H335-H410

Precautionary statements

P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

T+,N,T,C,F

Risk Statements

25-26-36/37/38-43-50-34-11

Safety Statements

26-36/37-45-61-38-36/37/39-28A-24-16

RIDADR

UN 2811 6.1/PG 1

WGK Germany

3

RTECS

QL7175000

F

8

Hazard Note

Very Toxic

TSCA

Yes

HazardClass

6.1

PackingGroup

I

HS Code

29146910

Toxicity

LD50 orally in Rabbit: 190 mg/kg LD50 dermal Rat 202 mg/kg

NFPA 704

	1
4		0

1,4-Naphthoquinone price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.06215	1,4-Naphthoquinone for synthesis	130-15-4	5G	$41.6	2024-03-01	Buy
Sigma-Aldrich	8.06215	1,4-Naphthoquinone for synthesis	130-15-4	250g	$77.9	2024-03-01	Buy
Sigma-Aldrich	8.06215	1,4-Naphthoquinone for synthesis	130-15-4	25kg	$4240	2024-03-01	Buy
Sigma-Aldrich	152757	1,4-Naphthoquinone 97%	130-15-4	5g	$51.6	2024-03-01	Buy
Sigma-Aldrich	152757	1,4-Naphthoquinone 97%	130-15-4	100g	$52	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.06215	5G	$41.6	Buy
8.06215	250g	$77.9	Buy
8.06215	25kg	$4240	Buy
152757	5g	$51.6	Buy
152757	100g	$52	Buy

1,4-Naphthoquinone Chemical Properties,Uses,Production

Chemical Properties

1,4-Naphthoquinone is a yellow to greenish yellow crystalline solid that has pungent odor like benzoquinone. It is slightly soluble in water, soluble in ether, chloroform, benzene, glacial acetic acid. In alkaline solutions it produces a reddish-brown color.

Uses

antibacterial, antineoplastic

Uses

1,4-Naphthoquinone is used as a strong dienophile in Diels-Alder reaction. It is also used as a precursor to anthroquinone and 5-nitro-1,4-naphthalenedione, which finds application in the preparation of aminoanthroquinone and is also used as a dye precursor. It is a basic component of Vitamin K.

Definition

ChEBI: 1,4-naphthoquinone is the parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties. It derives from a hydride of a naphthalene.

Application

1,4-Naphthoquinone is an important organic intermediate compound, it is the chemical intermediate of fungicide dichlone and dithianon, and also the by-product of anthraquinone synthesis. It can be used as polymerisation regulator of rubber and polyester resin, synthesis of dyestuffs and drugs, algaecide, corrosion inhibitor, stabiliser of transformer oil, etc.

Origin

1,4-Naphthoquinone is a natural product that is widely distributed in nature and is found in black walnut and king walnut. Especially in several families of higher plants (like Plumbaginaceae, Juglandaceae, Ebenaceae, Boraginaceae, Dioncophyllaceae, Ancistrocladaceae, Iridaceae, Verbenaceae, Scrophulariaceae, Avicenniaceae, Balsaminaceae, Bignoniaceae, Gentianaceae, and Droseraceae), and in addition also being present in algae, fungi, some animals, and products of metabolism in some bacteria.

Synthesis Reference(s)

Synthesis, p. 330, 1977 DOI: 10.1055/s-1977-24385
Tetrahedron Letters, 31, p. 4871, 1990 DOI: 10.1016/S0040-4039(00)97755-4

General Description

Yellow needles or brownish green powder with an odor of benzoquinone.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1,4-Naphthoquinone may react with many acids and bases liberating heat and flammable gases (e.g., H2). The heat may be sufficient to start a fire in the unreacted portion of the ketone. May react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. May react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Hazard

Irritant

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,4-Naphthoquinone emits toxic fumes and smoke.

Fire Hazard

Flash point data for 1,4-Naphthoquinone are not available; however, 1,4-Naphthoquinone is probably combustible.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

1,4-Naphthoquinone is prepared by reacting naphthalene with molecular oxygen in a gaseous phase in the presence of a catalyst containing vanadium.
Prior to reacting the naphthalene with oxygen, the catalyst is pre-treated with molecular oxygen at 300° to 400° C in the absence of organic compounds and immediately thereafter a gas mixture containing naphthalene and molecular oxygen is passed over the pretreated catalyst at temperatures in the range of 300° to 400° C. The catalyst pre-treatment can be carried out in the presence of water vapor and the subsequent reaction of naphthalene with molecular oxygen can also be carried out in the presence of water vapor.

Potential Exposure

1,4-Naphthoquinone is used as a polymerization regulator for rubber and polyester resins; in the synthesis of dyes and pharmaceuticals; and as a fungicide and algicide.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise the quinone from diethyl ether (charcoal). It distils in steam. It also crystallises from *benzene or aqueous EtOH and sublimes in a vacuum. [Beilstein 7 IV 2422.]

Incompatibilities

Ketones are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines, azo, diazo, azido compounds, carbamates, organic cyanates. May react with many acids and bases liberating heat and flammable gases (e.g., hydrogen) generating heat may be sufficient to start a fire in the unreacted portion of the ketone. May react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (e.g., hydrogen) and heat. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. May react violently with aldehydes.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

1,4-Naphthoquinone synthesis

Synthesis of 1,4-Naphthoquinone from 1-Naphthol

1,4-Naphthoquinone Preparation Products And Raw materials

Raw materials

1-Naphthol Sodium dichromate dihydrate Chromium(VI) oxide Potassium dichromate

Preparation Products

Nile Red 2-Hydroxy-1,4-naphoquinone 2,3-Dichloro-1,4-naphthoquinone Atovaquone Sodium silicate

2,3-DIMETHYLANTHRAQUINONE 3,3'-Dichlorobenzidine dihydrochloride 2-Chloro-1,4-naphthoquinone 1H-[1]-BENZAZEPHE-2,5(3H, 4H)-DIONE 4-METHOXY-1-NAPHTHOL

2-HYDROXYANTHRAQUINONE 1,4-Dihydroxynaphthalene MFCD00666862 1,4-Naphthalenedione, 2-chloro-3-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]- 4-METHOXY-2-PHENYLAZO-1-NAPHTHOL

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1,4-Naphthoquinone Suppliers

Global( 456)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Zhongxin Chemtech Co., Ltd.	+86-022-66880623 +8618622897568	sales@tjzxchem.com	China	559	58
Jiangsu Guotai Guomian Trading Co. Ltd.	+86-512-58916079 +86-13601562190	pharmachem@gtgmt.com	China	148	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	305	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-13102810335	admin@hbsaisier.cn	China	690	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55

Supplier	Advantage
Tianjin Zhongxin Chemtech Co., Ltd.	58
Jiangsu Guotai Guomian Trading Co. Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Xiamen Wonderful Bio Technology Co., Ltd.	58
Hebei Saisier Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55

View Lastest Price from 1,4-Naphthoquinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	1,4-Naphthoquinone 130-15-4	US $0.00 / KG	1KG	99%	2000mt	Jinan Finer Chemical Co., Ltd
2024-04-19	1,4-Naphthoquinone 130-15-4	US $6.00 / KG	1KG	More than 99%	2000KG/Month	Hebei Saisier Technology Co., LTD
2024-01-18	1,4-naphthoquinone 130-15-4	US $66.00 / kg	1kg	99%	30t	Xiamen Wonderful Bio Technology Co., Ltd.

1,4-Naphthoquinone
130-15-4
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

1,4-Naphthoquinone
130-15-4
US $6.00 / KG
More than 99%
Hebei Saisier Technology Co., LTD

1,4-naphthoquinone
130-15-4
US $66.00 / kg
99%
Xiamen Wonderful Bio Technology Co., Ltd.

1,4-Naphthoquinone Spectrum

1,4-Naphthoquinone(130-15-4)¹HNMR 1,4-Naphthoquinone(130-15-4)¹³CNMR 1,4-Naphthoquinone(130-15-4)IR1

130-15-4(1,4-Naphthoquinone)Related Search:

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1,4-Naftochinon 1,4-Naphthylquinone ALPHA-NAPHTHOQUINONE 1,4-NAPHTHOQUINOLINE 1,4-NAPHTHOQUINONE 1,4-DIHYDRO-1,4-DIKETONAPHTHAL 1,4-DIHYDRO-1,4-DIKETONAPHTHALENE -Naphthoquinone p-Naphthoquinone Rcra waste number U166 rcrawastenumberu166 USAF cy-10 usafcy-10 1,4-Naphthochi 1,4-Naphthoquinone purum, >=96.5% (HPLC) 1,4-Naphthoquinone, 97% dry weight, contains up to 5% water 1,4-naphthoquinone anion radical 1,4-Naphthochinone α-Naphthoquinone 1,4-Naphthalenedione NAPHTHOQUINONE,1,4- 1,4-Napthoquinone 1,4-Naphthoquinone, Standard 1,4-DIOXONAPHTHALENE 1,4-Naphthoquinone, contains up to 6% water, 99% 1,4-Naphthoquinone 97% NAPTHOQUINONE,1,4-(RG) PARA-NAPHTHOQUINONE 1,4-Naphthochinon 1,4-Naphthoquinone, 97+% (dry wt.), cont. up to 5% water 1,4-naphthoquinone (alpha) 1,4-Dihydronaphthalene-1,4-dione 1,4-Naphthoquinone (dry wt.), cont. up to 5% water NAPHTHOQUINONE,1,4-(RG) 1,4-Naphthoquinone ,95% 1,4-Naphthoquinone,α-Naphthoquinone 1.4-Naphthoquinone 1g [130-15-4] Naphthalene-1,4-dione 97% 1,4 napthaquinone 1,4-Naphthoquinone, contains up to 6% water, 99% 100GR 1,4-Naphthoquinone, contains up to 6% water, 99% 500GR 1,4-NAPHTHOQUINONE FOR SYNTHESIS 1,4-Naphthoquinone,99%,contains up to 6% water Dapoxetine Impurity R нафтахинон, нафталин-1,4-дион, α-Naphthoquinone, п-нафтахинон, 1,4-Naphthoquinone, Naphthalene-1,4-dion 1,4-napthaquinone,Naphthoquinone 1,4-Naphthoquinone> 1,4-Naphthoquinone @100 μg/mL in Dichloromethane 1,4-NaphthoquinoneSolution,1,000mg/L,1ml 1,4-Naphthoquinone,>98% 1,4-Naphthoquinone ISO 9001：2015 REACH 4-Di-hydroxyphenyl)-ethanol 4-dihydroxyphenylethanol 1,4-Naphthaquinone 1,4-naphtoquinone A-NAPHTHOQUINONE 1,4-NAPHTHALENEDIONE Naphthoquinone Naphthalene-1,4-dione