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Minoxidil

an antihypertensive vasodilator medication Indications and Usage Mechanisms of Action Adverse reactions Contradictions
Minoxidil
Minoxidil
CAS No.
38304-91-5
Chemical Name:
Minoxidil
Synonyms
pdp;PPM2C;regain;lonolox;alostil;regaine;rogaine;U-10858;loniten;prexidil
CBNumber:
CB7383531
Molecular Formula:
C9H15N5O
Formula Weight:
209.25
MOL File:
38304-91-5.mol

Minoxidil Properties

Melting point:
272-274 °C (dec.)(lit.)
storage temp. 
Store at RT
pka
4.61(at 25℃)
Water Solubility 
Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck 
14,6203
CAS DataBase Reference
38304-91-5(CAS DataBase Reference)
NIST Chemistry Reference
Minoxidil(38304-91-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T+
Risk Statements  22-36/37/38-26/27/28
Safety Statements  26-36-45-36/37/39-22
WGK Germany  3
RTECS  UV8200000
Hazardous Substances Data 38304-91-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Minoxidil price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M2300000 Minoxidil European Pharmacopoeia (EP) Reference Standard 38304-91-5 1EA $168 2017-11-08 Buy
Sigma-Aldrich 1444208 Minoxidil United States Pharmacopeia (USP) Reference Standard 38304-91-5 125mg $276.6 2017-11-08 Buy
TCI Chemical M1389 Minoxidil >98.0%(HPLC)(T) 38304-91-5 1g $29 2017-12-01 Buy
TCI Chemical M1389 Minoxidil >98.0%(HPLC)(T) 38304-91-5 5g $87 2017-12-01 Buy
Alfa Aesar J61803 Minoxidil 38304-91-5 5g $98.7 2017-11-08 Buy

Minoxidil Chemical Properties,Uses,Production

an antihypertensive vasodilator medication

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.
Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.

Indications and Usage

Minoxidil is a type of oral drug that is clinically used to lower blood pressure, and it is also called Loniten and piperidine diamine. Minoxidil is an antihypertensive drug that is clinically used to treat intractable, primary or renal hypertension. It can also be used to treat severe hypertension that does not respond well to other antihypertensive drugs, but it needs to be used in combination with diuretic drugs to prevent water and sodium retention, and combined use with beta receptor blockers may increase its curative effects and reduce adverse effects. Minoxidil is also used to prevent grease-type alopecia and on livestock.

Mechanisms of Action

Minoxidil is a type of potassium channel opener and can directly relax smooth vascular muscles and has a strong small artery dilating effect. It can reduce peripheral resistance, dilate blood vessels, and lower blood pressure while having no effect on blood volume, thus promoting venous return. In addition, due to reflective regulation and positive frequency effects, it can increase cardiac output and heart rate, but will not cause orthostatic hypotension.

Adverse reactions

Long term use of Minoxidil may have the side effect of increased body hair, such as arm hair.
Adverse reactions to oral intake mainly include: weight gain and lower body swelling due to water and sodium retention, heart palpitations and arrhythmia due to reflexive sympathetic nervous excitement, and hirsuitism.
Adverse reactions to external use mainly include: skin irritation, red spots in applied areas, itching, and other skin inflammation reactions. Although only a small amount is absorbed, but there is also a slight possibility of causing a recurrence in patients with a history or heart disease. Use with caution if suffering from cerebrovascular disease, non-hypertensive heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases.

Contradictions

Do not use if allergic to Minoxidil or suffering from pheochromocytoma.

Chemical Properties

White Crystalline Solid

Uses

antihypertensive, antialopecia agent

Uses

A selective ATP dependent K+ (Kir6) channel activator

Uses

Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels

Definition

ChEBI: A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.

Biological Activity

Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.

Minoxidil Preparation Products And Raw materials

Raw materials

Preparation Products


Minoxidil Suppliers

Global( 280)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20811 55
VOT INTERNATIONAL BUSINESS CO.,LTD 0536-2456718
0536-8231856 market@votchemical.com China 236 55
Hubei XinyuanShun Chemical Co., Ltd. 13971561712 / 13995564702 / 027-50664929
027-50664927 hbeixys2001@163.com China 3137 55
Wuhan Hezhong Bio-chemical Manufacture co ltd 021-68580715 / 18930710487
nikki@pharm-china.com China 2016 55
Nanjing Elegant Nutraceuticals Co., Ltd 0086-25-83241153, 83241163
0086-25-83241173 sales@elegantnutri.com China 51 55
Wuhai Shuou Technology Co., Ltd. 18973037581 / QQ:2355327072
027-88211932 liul@yuanchengtech.com China 3202 55
Kono Chem Co.,Ltd 029-86107037-8018
029-86107037 info@konochemical.com China 922 55
Hubei Widely Chemical Technology Co., Ltd. 027-51119224 18602735115
027-51119224 18602735115@163.com China 5027 64
Foshan DaoQi Biological Co., Ltd. 0757-86287544 18038709356
0757-86287544 wcq@chembj.com CHINA 3020 58

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