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Sodium Butyrate

CAS No.
156-54-7
Chemical Name:
Sodium Butyrate
Synonyms
NAB;SODIUM BUTANOATE;SODIUM N-BUTYRATE;BUTYRIC ACID SODIUM SALT;N-BUTYRIC ACID SODIUM SALT;Sodium Butyrate - CAS 156-54-7 - Calbiochem;Natriumbutyrat;butyratesodium;SODIUM BUTYRATE;BUTYRIC ACID NA
CBNumber:
CB7391358
Molecular Formula:
C4H7NaO2
Molecular Weight:
110.09
MDL Number:
MFCD00002816
MOL File:
156-54-7.mol
MSDS File:
SDS
Last updated:2025-10-18 16:00:31
Product description Number Pack Size Price
Sodium butyrate for synthesis 8.20236 250g $152
Sodium butyrate for synthesis 8.20236 1kg $533
Sodium butyrate special quality 8.17500 100g $65.7
Sodium butyrate United States Pharmacopeia (USP) Reference Standard 1613600 25mg $455
Sodium butyrate certified reference material, TraceCERT 07596 100mg $131
More product size

Sodium Butyrate Properties

Melting point 250-253 °C (lit.)
Density 1.324 g/cm3 (30℃)
storage temp. Store below +30°C.
solubility Methanol (Slightly), Water (Slightly)
form Amorphous Powder
color White
biological source synthetic (organic)
Water Solubility soluble
Sensitive Hygroscopic
BRN 3629439
Stability Stable. Incompatible with strong acids.
InChI InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
InChIKey MFBOGIVSZKQAPD-UHFFFAOYSA-M
SMILES C(CC)C([O-])=O.[Na+]
LogP 0.777 (est)
CAS DataBase Reference 156-54-7(CAS DataBase Reference)
FDA UNII 8RAS91C36W
NIST Chemistry Reference Sodium butyrate(156-54-7)
NCI Drug Dictionary sodium butyrate
EPA Substance Registry System Butanoic acid, sodium salt (156-54-7)
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  36/37/38-68
Safety Statements  37/39-26-24/25-36/37
RTECS  ET6400000
3-10
HS Code  29156000
Hazardous Substances Data 156-54-7(Hazardous Substances Data)
NFPA 704
1
2 1

Sodium Butyrate price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.20236 Sodium butyrate for synthesis 156-54-7 250g $152 2025-07-31 Buy
Sigma-Aldrich 8.20236 Sodium butyrate for synthesis 156-54-7 1kg $533 2025-07-31 Buy
Sigma-Aldrich 8.17500 Sodium butyrate special quality 156-54-7 100g $65.7 2025-07-31 Buy
Sigma-Aldrich 1613600 Sodium butyrate United States Pharmacopeia (USP) Reference Standard 156-54-7 25mg $455 2025-07-31 Buy
Sigma-Aldrich 07596 Sodium butyrate certified reference material, TraceCERT 156-54-7 100mg $131 2025-07-31 Buy
Product number Packaging Price Buy
8.20236 250g $152 Buy
8.20236 1kg $533 Buy
8.17500 100g $65.7 Buy
1613600 25mg $455 Buy
07596 100mg $131 Buy

Sodium Butyrate Chemical Properties,Uses,Production

Chemical Properties

Sodium butyrate is a white crystalline solid with an unpleasant smell that occurs in butter and animal fat as the glycerol ester. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre.

Uses

Sodium butyrate has been used:
as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Uses

Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas.

Definition

ChEBI: Sodium butyrate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor and a geroprotector. It contains a butyrate.

benefits

Sodium butyrate, a butyrate, is used in supplements. The benefits of butyrate begin in the gut and extend to a host of other important body systems. It could fuel the gut lining, support healthy gut permeability. promote a healthy inflammation response in the gut, may fight colonic diseases and cancers, promote healthy blood sugar levels, supports normal proliferation of healthy yeast levels, promote cell differentiation, regulate the immune system , combat brain fog and improve sleep, and supports healthy blood pressure levels.

Biological Activity

Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Synthesis

Butyric anhydride

106-31-0

Sodium Butyrate

156-54-7

The general procedure for the synthesis of sodium butyrate from butyric anhydride was as follows: the composition of Example 1b (25 mg, 0.16 mmol) was transferred from an Eppendorf tube to a sample cup and the sample cup was placed in a DNP polarizer. The composition was hyperpolarized using microwave (93.915 GHz) irradiation under a 3.35 T magnetic field and 1.2 K DNP for 75 minutes. Subsequently, the hyperpolarized sample was dissolved in 4 mL of water and NaOH (50 μL, 12 M solution) was added to adjust the pH of the dissolved sample to 12. The solution was transferred directly into a 10 mm NMR tube and placed in a 14.1 T magnetic field, and the time series of 1D 13C-NMR spectra at 5°C were recorded with a total delay of 1 s between pulses.After 10 s, butyric anhydride was quantitatively hydrolyzed (hydrolysis rate up to 95%). The butyric anhydride was well polarized and easily hydrolyzed to produce sodium butyrate.

storage

Room temperature

Purification Methods

Sodium butyrate [156-54-7] M 110.1. Prepare it by neutralising the acid with Na2CO3, and recrystallising it from EtOH. [Beilstein 2 IV 779.]

References

[1] Patent: US9694090, 2017, B2. Location in patent: Page/Page column 26; 27

106-31-0
156-54-7
Synthesis of Sodium Butyrate from Butyric anhydride
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US $33.00 / mg 99.79% 10g TargetMol Chemicals Inc.
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US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
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