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3,3'-Diindolylmethane

3,3'-Diindolylmethane Structure
3,3'-Diindolylmethane structure
CAS No.
1968-05-4
Chemical Name:
3,3'-Diindolylmethane
Synonyms
DIM;68-05-4;HB 236;ARUNDINE;Plant Indole;Indole dimer;Diindole methane;Di(1H-indol-3-yl);DI INDOLYL METHANE;DI-3-INDOLYLMETHANE
CBNumber:
CB7396111
Molecular Formula:
C17H14N2
Molecular Weight:
246.31
MDL Number:
MFCD00195766
MOL File:
1968-05-4.mol
MSDS File:
SDS
Last updated:2024-04-09 22:15:29
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3,3'-Diindolylmethane Properties

Melting point 167 °C
Boiling point 230 °C(Press: 0.01 Torr)
Density 1.271±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 16.91±0.30(Predicted)
form Off-white powder.
color White to Pale Beige
InChI InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
InChIKey VFTRKSBEFQDZKX-UHFFFAOYSA-N
SMILES C(C1C2=C(NC=1)C=CC=C2)C1C2=C(NC=1)C=CC=C2
LogP 4.401 (est)
CAS DataBase Reference 1968-05-4(CAS DataBase Reference)
FDA UNII SSZ9HQT61Z
NCI Dictionary of Cancer Terms diindolylmethane; DIM
NCI Drug Dictionary diindolylmethane

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H413
Precautionary statements  P273-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-26
WGK Germany  3
RTECS  NM0332000
HazardClass  IRRITANT
HS Code  29349990
NFPA 704
0
2 0

3,3'-Diindolylmethane price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9568 3,3′-Diindolylmethane ≥98% (HPLC) 1968-05-4 5G $181 2023-06-20 Buy
Sigma-Aldrich 74601 3,3′-Diindolylmethane analytical standard 1968-05-4 100MG $175 2022-05-15 Buy
TCI Chemical M1399 3,3'-Methylenediindole >98.0%(N) 1968-05-4 5g $60 2024-03-01 Buy
TCI Chemical M1399 3,3'-Methylenediindole >98.0%(N) 1968-05-4 25g $182 2024-03-01 Buy
Cayman Chemical 15927 3,3'-Diindolylmethane ≥98% 1968-05-4 100mg $32 2024-03-01 Buy
Product number Packaging Price Buy
D9568 5G $181 Buy
74601 100MG $175 Buy
M1399 5g $60 Buy
M1399 25g $182 Buy
15927 100mg $32 Buy

3,3'-Diindolylmethane Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.

Uses

An antineoplastic agent that activates Chk 2 and cytochrome p450

Uses

apoptosis inducer

Definition

ChEBI: 3,3'-diindolylmethane is a member of indoles. It has a role as an antineoplastic agent and a P450 inhibitor.

General Description

3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.

Biological Activity

3,3'-diindolylmethane is an anticancer agent [1].3,3'-diindolylmethane (dim) is a dimer of indole-3-carbinol generated in low ph environment. it inhibited cell growth with ic50 values of 17, 24 and 30 μm in mcf-7, t47d and saos2 cell lines, respectively. dim induced apoptosis in these cells without affecting the p53 pathway. in human nasopharyngeal carcinoma (npc) cell line (5-8f npc), treatment of dim decreased the ability of cell migration and invasion dose-dependently. in rats, transplanted with npc cells, dim administration resulted in suppressing lymph node metastasis. besides that, dim was found to induce erα target gene expression and the concomitant cell proliferation at low concentration (10μm) in the absence of e2 [1, 2 and 3].

Biochem/physiol Actions

Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

References

1. ge x, yannai s, rennert g, et al. 3, 3′-diindolylmethane induces apoptosis in human cancer cells. biochemical and biophysical research communications, 1996, 228(1): 153-158. 2. wu t, chen c, li f, et al. 3, 3' diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. experimental and therapeutic medicine, 2014, 7(6): 1635-1638. 3. marques m, laflamme l, benassou i, et al. low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. bmc cancer, 2014, 14(1): 524.

3,3'-Diindolylmethane Preparation Products And Raw materials

Raw materials

Preparation Products

5,11-dihydro-5-phenylindolo[3,2-b]carbazole

3,3'-Diindolylmethane Suppliers

Global( 462)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 616 58
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@airuikechemical.com China 994 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+86-13474506593 +86-13474506593 sarah@tnjone.com China 874 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Rixing Chemical CO.,LTD 		+86-13237129059 -13237129059 sales@rixingchemi.com CHINA 229 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
airuikechemical co., ltd. 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Rixing Chemical CO.,LTD 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58

View Lastest Price from 3,3'-Diindolylmethane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,3'-Diindolylmethane pictures 2024-04-24 3,3'-Diindolylmethane
1968-05-4
 US $0.00-0.00 / kg 1kg 3 3'-Diindolylmethane Dim Diindolylmethane 3000kg Jinan Jianfeng Chemical Co., Ltd
3,3'-Diindolylmethane pictures 2024-04-23 3,3'-Diindolylmethane
1968-05-4
 US $0.00 / KG 1KG 99% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
3,3′-diindolylmethane pictures 2024-04-09 3,3′-diindolylmethane
1968-05-4
 US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
  • 3,3'-Diindolylmethane pictures
  • 3,3'-Diindolylmethane
    1968-05-4
  • US $0.00-0.00 / kg
  • 3 3'-Diindolylmethane Dim Diindolylmethane
  • Jinan Jianfeng Chemical Co., Ltd

3,3'-Diindolylmethane Spectrum

3,3'-Diindolylmethane(1968-05-4)MS3,3'-Diindolylmethane(1968-05-4)IR13,3'-Diindolylmethane(1968-05-4)IR2

1968-05-4(3,3'-Diindolylmethane )Related Search:

Dibromomethane DIETHOXYMETHANE Diiodomethane Diphenylmethane 4,4'-Methylenedianiline
Dibenzoylmethane 1H-INDOL-3-OL 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-METHOXYPHENOL 3,3'-Diindolylmethane AURORA 23218
4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-ETHOXYPHENOL 3,3'-((4-METHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE) 1-(2,4-DICHLOROBENZYL)-3-(1-[1-(2,4-DICHLOROBENZYL)-1H-INDOL-3-YL]VINYL)-1H-INDOLE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-(1-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-INDOL-3-YL)VINYL)-1H-INDOLE 2-[2,2-BIS-(1H-INDOL-3-YL)-ETHYL]-PHENYLAMINE
4-(2-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-4,6-DICHLOROPHENYL)MORPHOLINE 1'-ACETYL-1H,1'H-3,3':3',3'-TERINDOL-2'(1'H)-ONE 3,3'-((3,4-DIMETHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE)

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3,3'-Diindolylmethane(DIM) Di(1H-indol-3-yl) Plant Indole 3,3'-DIINDOLYLMETHANE, >=98% (HPLC) 3,3'-METHYLENEBIS-1H-INDOLE 3,3'-METHYLENEBISINDOLE 3,3'-METHYLENEDIINDOLE 3,3'-DIINDOLYLMETHANE ARUNDINE BIS(3-INDOLYL)METHANE DI-INDOYLMETHANE, 3,3'- DI INDOLYL METHANE DI-3-INDOLYLMETHANE 2-carboxy-5-nitrobenzne sulfonic acid DIINDOLYLMETHANE(DIM) 3-DIINDOLYL METHANE Indolyl-CH2-Indolyl 3,3-DI-INDOLY-METHANE Indole dimer Diindole methane 3,3’-Diindolylmethane 3,3'-Methylenebisindole Di(1H-indol-3-yl)Methane DI-INDOLYLMETHANE, 3,3'-(RG) 1H-Indole,3,3'-Methylenebis- 3,3'-DiindolylMethane, 98%, 98% 3,3'-BisindolylMethane Bis(1H-indol-3-yl)Methane 3,3'-Methylenediindole HB 236 3,3'-Diindolymetane DI-INDOYLMETHANE, 3,3'-(P) 3,3'-Methylenediindole> 3,3'-Diindolylmethane / diindolylmethane 3,3'-Diindolylmethane ISO 9001：2015 REACH 1968-05-4 3,3'-Diindolylmethane DIM 68-05-4 3,3'-Diindolylmethane 99%min DIINDOLYLMETHANE, 3,3'- 3,3'-Diindolylmethane 1968-05-4 196-85-4 1968-5-4 1968-05-04 68-05-4 1968-05-1 1968-05-2 968-05-4 C17H14N2 Indoles Simple Indoles Inhibitors Pharmaceutical intermediates Gene Regulation Gene Regulation and Expression Alkaloid Antitumor Agents Aromatic Compounds Building Blocks