BGC 20-1531 (hydrochloride)
- CAS No.
- 1962928-26-2
- Chemical Name:
- BGC 20-1531 (hydrochloride)
- Synonyms
- AP 1531;BGC20-1531 (PGN-1531;AP-1531 hydrochloride;GTPL3380 hydrochloride;BGC 20-1531 (hydrochloride);BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base);4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
- CBNumber:
- CB74666962
- Molecular Formula:
- C26H25ClN2O6S
- Molecular Weight:
- 529
- MDL Number:
- MFCD30182277
- MOL File:
- 1962928-26-2.mol
BGC 20-1531 (hydrochloride) price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19742 | BGC 20-1531 (hydrochloride) ≥98% | 1962928-26-2 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19742 | BGC 20-1531 (hydrochloride) ≥98% | 1962928-26-2 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 19742 | BGC 20-1531 (hydrochloride) ≥98% | 1962928-26-2 | 5mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 19742 | BGC 20-1531 (hydrochloride) ≥98% | 1962928-26-2 | 10mg | $335 | 2024-03-01 | Buy |
| Tocris | 5327 | BGC20-1531hydrochloride ≥98%(HPLC) | 1962928-26-2 | 10 | $332 | 2021-12-16 | Buy |
BGC 20-1531 (hydrochloride) Chemical Properties,Uses,Production
Description
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; ) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. It is selective for EP4, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.
Uses
BGC 20-1531 Hydrochloride, is a potent and selective EP4 antagonist, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. It also Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arterieshuman middle cerebral and middle meningeal arterial rings.
storage
Desiccate at RT
BGC 20-1531 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
BGC 20-1531 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4196 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |