S-Carboxymethyl-L-Cysteine
- CAS No.
- 638-23-3
- Chemical Name:
- S-Carboxymethyl-L-Cysteine
- Synonyms
- S-BINAP;carbocisteine;CARBOCYSTEINE;carbocistene;S-Carboxymethyl-L-cysteine;SCMC;CARBOXYMETHYL-L-CYSTEINE;s-carboxylmethyl-l-cysteine;S-CMS;Lisil
- CBNumber:
- CB7467567
- Molecular Formula:
- C5H9NO4S
- Molecular Weight:
- 179.19
- MDL Number:
- MFCD00002614
- MOL File:
- 638-23-3.mol
- MSDS File:
- SDS
| Melting point | 208-213 °C (dec.) |
|---|---|
| Boiling point | 417.3±45.0 °C(Predicted) |
| alpha | -31 º (c=1, 10% NaH2CO3) |
| Density | 1.315 (estimate) |
| refractive index | 1.5216 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid, Aqueous Base (Sparingly, Sonicated) |
| pka | 2.06±0.10(Predicted) |
| form | Amorphous Powder |
| color | White to slightly off-white |
| Water Solubility | SOLUBLE IN COLD WATER |
| Merck | 14,1802 |
| BRN | 1725012 |
| LogP | 0.204 (est) |
| CAS DataBase Reference | 638-23-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 740J2QX53R |
| ATC code | R05CB03 |
| EPA Substance Registry System | L-Cysteine, S-(carboxymethyl)- (638-23-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AY4342000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29309090 | |||||||||
| Toxicity | LD50 oral in rat: > 15gm/kg | |||||||||
| NFPA 704 |
|
S-Carboxymethyl-L-Cysteine price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7757 | S-Carboxymethyl-L-cysteine | 638-23-3 | 1g | $38.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | C7757 | S-Carboxymethyl-L-cysteine | 638-23-3 | 5g | $40.14 | 2024-03-01 | Buy |
| TCI Chemical | C0863 | S-(Carboxymethyl)-L-cysteine >98.0%(HPLC)(T) | 638-23-3 | 25g | $37 | 2024-03-01 | Buy |
| Alfa Aesar | B23487 | S-Carboxymethyl-L-cysteine, 97% | 638-23-3 | 25g | $38.65 | 2024-03-01 | Buy |
| Alfa Aesar | B23487 | S-Carboxymethyl-L-cysteine, 97% | 638-23-3 | 100g | $104.65 | 2024-03-01 | Buy |
S-Carboxymethyl-L-Cysteine Chemical Properties,Uses,Production
Chemical Properties
white to slightly off-white amorphous powder
Originator
Rhinathiol,Kramer,Switz.
Uses
Labeled Carbocisteine, intended for use as an internal standard for the quantification of Carbocisteine by GC- or LC-mass spectrometry.
Uses
Carbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).
Uses
carbocysteine is an amino acid. It can be used to help control sebum production.
Definition
ChEBI: S-carboxymethyl-L-cysteine is an L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group. It has a role as a mucolytic. It is a L-cysteine thioether and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a S-carboxylatomethyl-L-cysteine(1-).
Manufacturing Process
There were placed 120g of L-cysteine (0.5 mol) in a 2 liter three-necked flask
equipped with a stirrer thermometer and methanol/dry ice cooling and 1.5
liters of liquid ammonia were allowed to enter at -40°C. Then there were
added under continuous cooling 50 g (2.17 mols) of sodium metal in portions
of 1 to 2 g during the course of one hour. The end of the reaction was
recognized by the continuation of the blue color. After the end of the reaction
the excess sodium was destroyed by the addition of ammonium chloride and
the ammonia vaporized at normal pressure. The residue was taken up in 500
ml of water and concentrated in a vacuum to 200 ml in order to remove
residual ammonia, and again treated with 300 ml of water. The entire
operations were carried out under a nitrogen atmosphere.
The aqueous solution of the disodium salt of L-cysteine obtained is then
reacted at 20°C to 30°C under a nitrogen atmosphere in the course of 30
minutes with stirring with a solution of 104 g of chloroacetic acid (1.1 mols)
and 4 g of sodium pyrosulfite in 200 ml of water. It is also allowed to post
react for 15 minutes at 20°C, the solution clarified over activated carbon and
the filtrate treated with 90 ml of concentrated hydrochloric acid to a pH of
2.5.
Thereby the S-carboxymethyl-L-cysteine precipitates out in crystalline form.
The product is filtered off with suction, well stirred in 500 ml of water, again
filtered with suction and dried in a vacuum at 70°C. The yield is 92% based
on L-cysteine.
brand name
Loviscol (Wyeth-Ayerst); Mucofan (Wyeth-Ayerst).
Therapeutic Function
Mucolytic, Expectorant, Nasal antiinfective
Biochem/physiol Actions
S-Carboxymethyl-L-cysteine is studied as a small molecule mucoactive drug in vivo. These studies include analyzing the oxidative metabolism of S-carboxymethyl-L-cysteine by enzymes such as phenylalanine monooxygenase(s).
Safety Profile
contact. A riot control agent. When heated
S-Carboxymethyl-L-Cysteine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 524 | 58 |
| Shandong Juchuang Chemical Co., LTD | +86-18885615001 +86-18885615001 | admin@juchuangchem.com | China | 387 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | +8615139564871 | wrjmoon2000@163.com | China | 354 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from S-Carboxymethyl-L-Cysteine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | S-Carboxymethyl-L-Cysteine
638-23-3
|
US $0.00 / kg | 1kg | 99% | 20tons | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-04-12 | S-Carboxymethyl-L-Cysteine
638-23-3
|
US $3.00-1.00 / kg | 1kg | 99.9% | 10 tons | Shanghai Aosiris new Material Technology Co., LTD | |
 |
2024-03-12 | S-Carboxymethyl-L-Cysteine
638-23-3
|
US $35.00-25.00 / kg | 1kg | 99.8% | 200tons/year | Sigma Audley |
-
- S-Carboxymethyl-L-Cysteine
638-23-3
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- S-Carboxymethyl-L-Cysteine
638-23-3
- US $3.00-1.00 / kg
- 99.9%
- Shanghai Aosiris new Material Technology Co., LTD
-
- S-Carboxymethyl-L-Cysteine
638-23-3
- US $35.00-25.00 / kg
- 99.8%
- Sigma Audley