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1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone structure

CAS No.: 50405-58-8

Chemical Name:: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone

Synonyms: TC-E 5008;TC E 5008,TCE 5008;6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one;1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone;2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(phenylmethyl)-

CBNumber:: CB74902655

Molecular Formula:: C13H13NO2

Molecular Weight:: 215.25

MDL Number:: MFCD30290154

MOL File:: 50405-58-8.mol

Last updated:2023-07-22 08:27:57

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1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	5244	TC-E5008	50405-58-8	10	$152	2021-12-16	Buy
Tocris	5244	TC-E5008	50405-58-8	50	$642	2021-12-16	Buy
TRC	T125135	TC-E5008	50405-58-8	10mg	$145	2021-12-16	Buy
TRC	T125135	TC-E5008	50405-58-8	50mg	$630	2021-12-16	Buy

Product number	Packaging	Price	Buy
5244	10	$152	Buy
5244	50	$642	Buy
T125135	10mg	$145	Buy
T125135	50mg	$630	Buy

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone Chemical Properties,Uses,Production

Uses

TC-E 5008 is a cancer-assocaited mutant isocitrate dehydrogenase inhibitor, which was found to be permeable through the blood-brain barrier.

Definition

ChEBI: SYC-435 is a cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant). It has a role as an EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor and an antineoplastic agent. It is a member of benzenes, a pyridone and a cyclic hydroxamic acid.

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone synthesis

Synthesis of 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone from 2H-Pyran-2-one, 4-methyl-6-(phenylmethyl)-

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone Preparation Products And Raw materials

Raw materials

Preparation Products

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone Suppliers

Global( 13)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3444	55
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4030	58

Supplier	Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
BOC Sciences	65
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Shanghai Hongye Biotechnology Co. Ltd	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone TC-E 5008 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(phenylmethyl)- 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one TC E 5008,TCE 5008 50405-58-8