6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
- CAS No.
- 545380-34-5
- Chemical Name:
- 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
- Synonyms
- QNZ;CS-902;EVP4593;EVP-4593;EVP 4593;CAY10470;QNZ (EVP4593);QNZ (EVP4593);EVP-4593;NF-κB Activation Inhibitor;EVP4593; EVP 4593; EVP-4593
- CBNumber:
- CB7500822
- Molecular Formula:
- C22H20N4O
- Molecular Weight:
- 356.42
- MDL Number:
- MFCD06411436
- MOL File:
- 545380-34-5.mol
- MSDS File:
- SDS
| Melting point | 169-175°C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H410 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501 |
| WGK Germany | 3 |
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0579 | EVP4593 ≥98% (HPLC) | 545380-34-5 | 5mg | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | 481406 | NF-κB Activation Inhibitor | 545380-34-5 | 1mg | $144 | 2024-03-01 | Buy |
| Alfa Aesar | J67487 | QNZ, 98% | 545380-34-5 | 1mg | $68.3 | 2023-06-20 | Buy |
| Alfa Aesar | J67487 | QNZ, 98% | 545380-34-5 | 0.5mg | $25.4 | 2021-12-16 | Buy |
| Cayman Chemical | 10006734 | QNZ ≥98% | 545380-34-5 | 500μg | $20 | 2024-03-01 | Buy |
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Chemical Properties,Uses,Production
Description
QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50?= 11 nM) and TNF-α?production (IC50?= 7 nM).1,2?It indirectly inhibits the NF-κB pathway via inhibition of store-operated calcium entry (SOC) and displayed neuroprotective effects in transgenic fly and mouse models of Huntington’s disease.3,4?Its target has been postulated to be heteromeric calcium channels containing TRPC1 as one of the subunits.4?QNZ reduced synaptic neuronal SOC and rescued dendritic spine loss in YAC128 striatal medium spiny neurons.5?QNZ has also been identified as a potent (IC50?= 25 nM complex 1 from?Y.lipolytica; IC50?= 14 nM complex 1 from?Bos Taurus?heart mitochondria) and selective inhibitor of mitochondrial complex I.6?QNZ?decreased PSEN1ΔE9-mediated nSOCE upregulation and rescued mushroom spines in PSEN1ΔE9-expressing neurons, which are linked to familial Alzheimer’s disease.7
Chemical Properties
White Solid
Uses
QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1m
Uses
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.
target
NF-κB
References
1) Tobe?et al. (2003),?Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation; Bioorg. Med. Chem. Lett,?11?383 2) Tobe?et al.?(2003),?A novel structural class of potent inhibitors of NF-kB activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives; Bioorg. Med. Chem. Lett,?11?3869 3) Choi?et al.?(2006),?Nuclear factor-kappaB activated by capacitive Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells; J. Biol. Chem.,?281?12722 4) Wu?et al.?(2011),?Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington’s Disease Treatment; Chem. Biol.,?18?777 5) Wu?et al. (2016),?Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington’s Disease Mouse Model; J. Neurosci.,?36?125 6) Krishnathas?et al. (2017),?Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I; Medchemcomm.?8?657 7) Chernyuk?et al. (2019),?Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1?E9 mutant linked to familial Alzheimer disease;?Neuroscience,?410?118
6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
View Lastest Price from 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-04-12 | 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI
545380-34-5
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
-
- 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUI
545380-34-5
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd