Monensin sodium salt

Monensin sodium salt Properties

Melting point	267-269 C
alpha	57.3 º (c=4.0, in MeOH)
storage temp.	2-8°C
solubility	Soluble in methanol at 50mg/ml
form	Off-white to beige solid
color	White
BRN	4122200
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	XOIQMTLWECTKJL-BEMBKCOJSA-M
LogP	3.716 (est)
FDA UNII	1GS872GAFV
EPA Substance Registry System	Monensin, monosodium salt (22373-78-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08,GHS09

Signal word

Danger

Hazard statements

H300-H319-H334-H373-H411

Precautionary statements

P260-P264-P273-P301+P310-P304+P340+P312-P305+P351+P338

Hazard Codes

T,T+

Risk Statements

25-26/27/28

Safety Statements

36/37/39-45-22

RIDADR

UN 3462 6.1/PG 2

WGK Germany

3

RTECS

JH2830000

HazardClass

6.1(a)

PackingGroup

II

HS Code

29419090

NFPA 704

	0
3		0

Monensin sodium salt price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2775	Monensin sodium PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer	22373-78-0	300MG	$158	2024-03-01	Buy
Sigma-Aldrich	46468	Monensin sodium salt hydrate VETRANAL	22373-78-0	100mg	$57.7	2024-03-01	Buy
Sigma-Aldrich	1445481	Monensin sodium United States Pharmacopeia (USP) Reference Standard	22373-78-0	200mg	$436	2024-03-01	Buy
Alfa Aesar	J61669	Monensin sodium salt, 90% min.	22373-78-0	1g	$66.2	2024-03-01	Buy
Cayman Chemical	16488	Monensin (sodium salt) ≥98%	22373-78-0	1g	$50	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR2775	300MG	$158	Buy
46468	100mg	$57.7	Buy
1445481	200mg	$436	Buy
J61669	1g	$66.2	Buy
16488	1g	$50	Buy

Monensin sodium salt Chemical Properties,Uses,Production

Description

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Chemical Properties

LIGHT CREAM AMORPHOUS POWDER

Uses

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

Uses

antibacterial

Uses

antifungal

Uses

Poliether antibiotic. Coccidiostat.

General Description

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

storage

-20°C

Purification Methods

Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].

References

Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767

Monensin sodium salt synthesis

Synthesis of Monensin sodium salt from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

Monensin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Monensin

Monensin sodium salt Suppliers

Global( 348)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7613	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	864	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	906	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Cangzhou Wanyou New Material Technology Co.,Ltd	58

View Lastest Price from Monensin sodium salt manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-16	Monensin sodium salt 22373-78-0	US $3.00-1.00 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2024-04-07	Monensin Sodium 22373-78-0	US $0.00 / kg	1kg	99%	1000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2023-09-21	Monensin sodium salt 22373-78-0	US $0.00 / kg	1kg	99%	20tons	Hebei Yanxi Chemical Co., Ltd.

Monensin sodium salt
22373-78-0
US $3.00-1.00 / kg
99%
Henan Fengda Chemical Co., Ltd

Monensin Sodium
22373-78-0
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Monensin sodium salt
22373-78-0
US $0.00 / kg
99%
Hebei Yanxi Chemical Co., Ltd.

Monensin sodium salt Spectrum

Monensin sodium salt(22373-78-0)MS

22373-78-0(Monensin sodium salt)Related Search:

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Sodium acetate Sodium chloride 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 3,6,9,12-tetraoxatetradecan-1-ol 2-[2-[(2-ETHYLHEXYL)OXY]ETHOXY]ETHANOL

PENTACOSANOIC ACID Monensin GLYCOFUROL

1of4

Coban45 gamma,2,8-tetramethyl--furyl)-2-furyl)-9-hydroxy-beta-methoxy-alphmonosod methyl-5-(tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2h-pyran-2-yl)-2 monensin,monosodiumsalt Monensin,monosodiumsalt(9CI) Previouscas:22136-43-2 Sodiummonensin 2-[5-Ethyltetrahydro-5-[tetrahydro-3-Methyl-5-[tetrahydro-6-hydroxy-6-(hydroxyMethyl)-3,5-diMethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-Methoxy-α,γ,2,8-tetraMethyl- MONENSIN SODIUM (Monensin A is shown) 1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, monosodium salt (8CI) Monensin sodium, 90-95% 1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsal 1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsalt MONENSIN SODIUM SALT 97% MONENSIN SODIUM SALT HYDRATE MONENSINSODIUM,USP 1,6-Dioxaspiro[4.5] decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5- [tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9- hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-, monosodium salt 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-oxan-2-yl]-3-methyl-oxolan-2-yl]oxolan-2-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methyl-pentanoic acid monosodium salt Monensin, sodium salt,97% 1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydrox y-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-metho xy-.alpha.,.gamma.,2,8-tetramethyl-, monosodium salt (8CI Sodium 4-[2-[2-Ethyl-3'-methyl-5'-(tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethylpyran-2-yl)perhydro-2,2'-bifuran-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl}-3-methoxy-2-methylpentanoate Monensin Sodium (200 mg) Monensin sodium salt,Monensin A sodium salt Monensin sodiuM salt(Coban) Monensin sodium salt Monensin sodium 40% 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem Monensin sodium salt, 90+ % Monensin sodium salt USP/EP/BP Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methoxy-2-methylpentanoate Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methox Monensin Sodium Salt (MSN), 90-95% Sodium (2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-[2,2'-bifuran]-5-yl]-9-hydroxy-2,8-dimethyl- Monensin sodium 20/40%/90% Coban RUMENSIN 22373-78-0 C36H61NaO11 C36H63NaO12 C36H61NaO11xH2O Antibiotics Antibiotics A to Z Antibiotics G-M BioChemical Inhibitors Organics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals 22373-78-0