ChemicalBook >> CAS DataBase List >>Fmoc-L-Arg(Pbf)-OH
Fmoc-L-Arg(Pbf)-OH
- CAS No.
- 154445-77-9
- Chemical Name:
- Fmoc-L-Arg(Pbf)-OH
- Synonyms
- FMOC-ARG(PBF);FMOC-L-ARG(PBF)-OH;Fomc-Arg(pbf)-OH;-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid;FMOC-L-ARG(PBF);FMOC-ARG(PBF)-OH;Fmoc-Arq(Pbf)-OH;Fmoc Pbf Arginine;Fmoc-Arg(Pbf) ,98%;FMOC-L-ARGININE(PBF)
- CBNumber:
- CB7764987
- Molecular Formula:
- C34H40N4O7S
- Molecular Weight:
- 648.77
- MDL Number:
- MFCD00235804
- MOL File:
- 154445-77-9.mol
- MSDS File:
- SDS
Last updated:2024-03-28 11:40:52
| Melting point | 132°C |
|---|---|
| alpha | -5.5 º (c=1,DMF) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -15°C to -25°C. |
| solubility | DMF (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.83±0.21(Predicted) |
| color | White to Off-White |
| optical activity | [α]/D -5.5±1.0°, c = 1 in DMF |
| BRN | 8302671 |
| InChIKey | YUMOVWGGELTYES-LJAQVGFWSA-N |
| SMILES | C(O)(=O)[C@H](CCCNC=NNS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| CAS DataBase Reference | 154445-77-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H335-H315-H312-H319-H302 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 2935 90 90 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
Fmoc-L-Arg(Pbf)-OH price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52067 | Fmoc-Arg(Pbf)-OH Novabiochem? | 154445-77-9 | 5G | $65.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.52067 | Fmoc-Arg(Pbf)-OH Novabiochem? | 154445-77-9 | 25g | $219 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.52067 | Fmoc-Arg(Pbf)-OH Novabiochem? | 154445-77-9 | 100g | $583 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.52067 | Fmoc-Arg(Pbf)-OH Novabiochem? | 154445-77-9 | 250g | $1170 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.52067 | Fmoc-Arg(Pbf)-OH Novabiochem? | 154445-77-9 | 1kg | $3070 | 2024-03-01 | Buy |
Fmoc-L-Arg(Pbf)-OH Chemical Properties,Uses,Production
Chemical Properties
white powde
Uses
Fmoc-Arg(Pbf)-OH is a Fmoc-protected amino acid derivative that can be used to create arginine-containing peptides. The 2,2,4,6,7-pentamethyIdlhydrobenzofuran-5-sulfonyl group (Pbf) can be easily cleaved by trifluoroacetic acid (TFA).
Uses
Fmoc-Arg(Pbf)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
Definition
Fmoc-Arg(Pbf)-OH is the standard derivative for the introduction of Arg in Fmoc SPPS. In the preparation of peptides containing both Arg and Trp, it is recommended that this derivative is used in conjunction with Fmoc-Trp(Boc)-OH. The Pbf side-chain protecting group is removed with TFA approximately 1-2 times faster than Pmc. TFA cleavage is best performed in the presence of a silane scavenger. The Pbf group of Fmoc-Arg(Pbf)-OH can be cleaved under moderate acid conditions.
General Description
Fmoc-Arg(Pbf)-OH, which is the most used building block for the introduction of Arg into SPPS, is the most expensive of all protected proteinogenic amino acids currently on the market and, like all Arg derivatives, it undergoes an important side-reaction upon activation. It is a highly problematic amino acid because of its ability to react intramolecularly, leading to its δ-lactam derivative. Arg is the key for the development of the so-called Cell-Penetrating Peptides[1].
Reactivity Profile
The Pbf group of Fmoc-L-Arg(Pbf)-OH can be cleaved under moderate acid conditions. The amount of tryptophan alkylation is significantly reduced compared to other arginine side chain protecting groups, especially in the absence of scavengers. In one example reported in the literature, a peptide containing Arg(Pmc) was cleaved, and deprotected TFA resulted in 46% of the desired peptide.
Solubility in organics
≥64.9 mg/mL in DMSO; insoluble in H2O; ≥2.14 mg/mL in EtOH with ultrasonic
References
[1] Torre B, et al. Successful Development of a Method for the Incorporation of Fmoc-Arg(Pbf)-OH in Solid-Phase Peptide Synthesis using N Butylpyrrolidinone (NBP) as Solvent. Green Chemistry, 2020; 22: 3162-3169.
Fmoc-L-Arg(Pbf)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 498)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lanxi Xingnuo Import and Export Trading Co., Ltd | +86-15888978871 +86-13901546477 | sales@xingnuotraders.com | China | 21 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
| Chengdu Baishixing Science and Technology Industry Co.,Ltd | +86-15008457246 +86-15008457246 | yuki@cd-bsx.com | China | 53 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8618980456393 | daisy@enlaibio.com | China | 1369 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 |
View Lastest Price from Fmoc-L-Arg(Pbf)-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Fmoc-L-Arg(Pbf)-OH
154445-77-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2024-04-17 | Fmoc-Arg(Pbf)-OH
154445-77-9
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-11-01 | Fmoc-Arg(pbf)-OH
154445-77-9
|
US $0.00 / Box | 1Box | 99% | 200kg | Hangzhou ICH Biofarm Co., Ltd |
-
- Fmoc-L-Arg(Pbf)-OH
154445-77-9
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Fmoc-Arg(Pbf)-OH
154445-77-9
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Fmoc-Arg(pbf)-OH
154445-77-9
- US $0.00 / Box
- 99%
- Hangzhou ICH Biofarm Co., Ltd
154445-77-9(Fmoc-L-Arg(Pbf)-OH)Related Search:
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N^a-FMoc-N^w-(2,2,4,6,7-pentaMethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl)-L-arginine, 98%
Na-FMoc-Nw-Pbf-L-arginine
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N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NG-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
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N-ALPHA-FMOC-N-G-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE
N-ALPHA-FMOC-N-OMEGA-PBF-L-ARGININE
N-ALPHA-FMOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE
N ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N OMEGA-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
Nα-FMoc-Nω-(2,2,4,6,7-pentaMethyldihydrobenzofuran-5-sulfonyl)-L-arginine
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L-Ornithine, N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-
Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-L-arginine≥ 99.5% (HPLC, Chiral purity)
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FMoc-Arg(Pbf)-OH >=98.0% (HPLC)
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FMOC-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine
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Nα-Fmoc-Nω-Pbf-L-arginine ,98%
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fmoc-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfon
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FMOC-L-ARG(PBF)-OH(154445-77-9)
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Nalpha-Fmoc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan)-5-sulfonyl-L-arginine
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid
Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nomega-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine>
FMOC-ARG(PBF)-OH 100 G
FMOC-ARG(PBF)-OH 250 G
FMOC-ARG(PBF)-OH 5 G
(2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoicaci