NCGC00092410
- CAS No.
- 442898-34-2
- Chemical Name:
- NCGC00092410
- Synonyms
- ML008;NCGC00092410;Cyclohexanecarboxamide, N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]-
- CBNumber:
- CB78065996
- Molecular Formula:
- C21H27N3O2
- Molecular Weight:
- 353.46
- MDL Number:
- MFCD14719081
- MOL File:
- 442898-34-2.mol
NCGC00092410 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0064922 | NCGC00092410 99.72% | 442898-34-2 | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0064922 | NCGC00092410 99.72% | 442898-34-2 | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0064922 | NCGC00092410 99.72% | 442898-34-2 | 25mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0064922 | NCGC00092410 99.72% | 442898-34-2 | 50mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0064922 | NCGC00092410 99.72% | 442898-34-2 | 100mg | $850 | 2021-12-16 | Buy |
NCGC00092410 Chemical Properties,Uses,Production
Definition
ChEBI: N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide is an aminoquinoline.
Biological Activity
NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease[1]. NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner[1].NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts[1].NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts[1].
References
[1]. Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7.
NCGC00092410 Preparation Products And Raw materials
Raw materials
Preparation Products
NCGC00092410 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Zhengzhou anmousse chemical products co. LTD | 0371-55289822 18737195735 | 483339295@qq.com | China | 7088 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4164 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29989 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |