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m-Cresol

CAS No.
108-39-4
Chemical Name:
m-Cresol
Synonyms
3-METHYLPHENOL;META-CRESOL;Phenol,3-methyl-;m-Cresole;m-Kresol;3-Cresol;M-METHYLPHENOL;m-Cesol;M-CRESOL;m-Toluol
CBNumber:
CB7852747
Molecular Formula:
C7H8O
Molecular Weight:
108.14
MDL Number:
MFCD00002302
MOL File:
108-39-4.mol
MSDS File:
SDS
Last updated:2023-11-30 10:44:40

m-Cresol Properties

Melting point 8-10 °C(lit.)
Boiling point 203 °C(lit.)
Density 1.034 g/mL at 25 °C(lit.)
vapor density 3.72 (vs air)
vapor pressure <1 mm Hg ( 20 °C)
FEMA 3530 | M-CRESOL
refractive index n20/D 1.541(lit.)
Flash point 187 °F
storage temp. Store below +30°C.
solubility 23.5g/l
pka 10.01(at 25℃)
form Liquid
color Clear colorless to slight red
PH 5 (20g/l, H2O, 20℃)
Odor at 0.01 % in dipropylene glycol. medicinal woody leather phenolic
Odor Type phenolic
Odor Threshold 0.0001ppm
explosive limit 1.06-1.35%, 150°F
Water Solubility 20 g/L (20 ºC)
λmax 273nm(lit.)
JECFA Number 692
Merck 14,2579
BRN 506719
Exposure limits ACGIH: TWA 20 mg/m3 (Skin)
NIOSH: IDLH 250 ppm; TWA 2.3 ppm(10 mg/m3)
Dielectric constant 11.5
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, aluminium, aluminium alloys. Air and light sensitive. Hygroscopic.
LogP 1.96
Substances Added to Food (formerly EAFUS) M-CRESOL
FDA 21 CFR 310.545
CAS DataBase Reference 108-39-4(CAS DataBase Reference)
EWG's Food Scores 5
FDA UNII GGO4Y809LO
NIST Chemistry Reference Phenol, 3-methyl-(108-39-4)
EPA Substance Registry System m-Cresol (108-39-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301+H311-H314-H412
Precautionary statements  P270-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  24/25-34-39/23/24/25-23/24/25
Safety Statements  36/37/39-45-36/37
RIDADR  UN 2076 6.1/PG 2
WGK Germany  1
RTECS  GO6125000
8
Autoignition Temperature 626 °C
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29071200
Toxicity LD50 orally in rats: 2.02 g/kg (Deichmann, Witherup)
NFPA 704
2
3 0

m-Cresol price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W353000 m-Cresol ≥98%, FG 108-39-4 1kg $96.8 2024-03-01 Buy
Sigma-Aldrich W353000 m-Cresol ≥98%, FG 108-39-4 10Kg $482 2024-03-01 Buy
Sigma-Aldrich W353000 m-Cresol ≥98%, FG 108-39-4 25kg $885 2024-03-01 Buy
Sigma-Aldrich 8.09691 m-Cresol for synthesis 108-39-4 100mL $61.4 2024-03-01 Buy
Sigma-Aldrich 8.09691 m-Cresol for synthesis 108-39-4 500mL $94.3 2024-03-01 Buy
Product number Packaging Price Buy
W353000 1kg $96.8 Buy
W353000 10Kg $482 Buy
W353000 25kg $885 Buy
8.09691 100mL $61.4 Buy
8.09691 500mL $94.3 Buy

m-Cresol Chemical Properties,Uses,Production

Uses

m-Cresol is an important organic intermediate (building block) to synthetize substituted aryl products.

Chemical Properties

Cresol is a mixture of the three isomeric cresols, o-, m-, and p-cresol. Cresols are slightly soluble in water. m-Isomer: Colorless or yellow liquid with characteristic odor.

Chemical Properties

colourless to light yellow liquid

Chemical Properties

m-Cresol has a dry, tarry, medicinal–leathery odor. m-Cresol and p-cresol very often occur together and are difficult to separate.

Occurrence

Reported found in beer, coffee, egg, grape, Oriental tobacco, roasted barley, rum, sherry and whiskey.

Uses

m-Cresol is employed in the preparation of synthetic resins like phenol-formaldehyde resins, disinfectants, and photographic developers. It is used as industrial solvent for dissolving polymers such as polyaniline. It acts as a precursor to vitamin E and antiseptic amylmetacresol. It is used as insuline preservatives.

Uses

Antiseptic; antimicrobial preservative.

Uses

m-Cresol is used as a disinfectant and solvent. LysolTM disinfectant is a 50% (v/v) mixed-cresol isomer in a soap emulsion formed on mixing with water. The isomer m-cresol is an oily liquid with low volatility. Besides disinfection at solutions of 1–5%, the cresols are used in degreasing compounds, paintbrush cleaners, and additives in lubricating oils. Cresols were once widely used for disinfection of poultry houses, but this use has been discontinued because they cause respiratory problems and abdominal edema in young chicks. m-Cresol has been used in synthetic resins, explosives, petroleum, photographic, paint, and agricultural industries.

Preparation

One process involving butylation and separation and followed by dealkylation produces m-cresol and ditertiary butyl p-cresol. From m, p-cresol (which is the main product of the recovery process) pure m-cresol can be obtained by extraction.

Production Methods

The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. m-Cresol is prepared from m-toluic acid or obtained from coal tar or petroleum (352, 355, 356). Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ~180–201°C. The m-cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.

Definition

ChEBI: A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.

Aroma threshold values

Aroma characteristics at 1.0%: phenolic, spicy eugenol-like, medicinal, smoky powdery with a leatherlike note.

Taste threshold values

Taste characteristics at 2 ppm: phenolic, smoky, balsamic, medicinal and spicy eugenol-like

General Description

Colorless liquid with a sweet tarry odor. Sinks and mixes slowly with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

m-Cresol is sensitive to air, light and heat. m-Cresol is also hygroscopic. m-Cresol can react vigorously with strong oxidizers and strong bases. m-Cresol reacts violently with nitric acid, oleum, chlorosulfonic acid, metals and strong acids. If the water content is below approximately 0.3% and the temperature above 248° F, the corrosion of aluminum and its alloys may occur violently. m-Cresol will attack some forms of plastics, coatings and rubber.

Hazard

Questionable carcinogen.

Health Hazard

INHALATION: Mucosal irritation and systemic poisoning EYES: Intense irritation and pain, swelling of conjunctiva, and corneal damage may occur. SKIN: Intense burning, loss of feeling, wrinkling, white discoloration, and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Acute exposure by all routes may cause muscular weakness, gastroenteric disturbances, severe depression, collapse. Effects are primarily on CNS and edema of lungs. Injury of spleen and pancreas may occur.

Flammability and Explosibility

Not classified

Contact allergens

Metacresol is contained as a preservative in almost all human insulin. It has been reported as a cause of allergic reaction due to injected insulin.

Safety Profile

v Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by skin contact. Severe eye and skin irritant. An experimental teratogen. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. Flammable when exposed to heat or flame. Moderately explosive in the form of vapor when exposed to heat or flame. See also other cresol entries and PHENOL.

Potential Exposure

Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.

Carcinogenicity

m-Cresol has induced a few papillomas but no carcinomas in tumor studies.

Shipping

UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.

Purification Methods

Separation of the m-and p-cresols requires chemical methods, such as conversion to their sulfonates [Brüchner Anal Chem 75 289 1928]. An equal volume of H2SO4 is added to m-cresol, stirred with a glass rod until solution is complete. Heat for 3hours at 103-105o. Dilute carefully with 1-1.5 volumes of water, heat to boiling point and steam distil until all unsulfonated cresol has been removed. Cool and extract the residue with ether. Evaporate the solution until the boiling point reaches 134o and steam distil off the m-cresol. Another purification method involves distillation, fractional crystallisation from the melt, then redistillation. Free from p-cresol by solution in glacial acetic acid and bromination by about half of an equivalent amount of bromine in glacial acetic acid. The acetic acid is distilled off, then fractional distillation of the residue under vacuum gives bromocresols from which 4-bromo-m-cresol is obtained by crystallisation from hexane. Addition of the bromocresol in glacial acetic acid slowly to a reaction mixture of HI and red phosphorus or (more smoothly) of HI and hypophosphorus acid, in glacial acetic acid, at reflux, removes the bromine. After an hour, the solution is distilled at atmospheric pressure until layers are formed. Then it is cooled and diluted with water. The cresol is extracted with ether, washed with water, NaHCO3 solution and again with water, dried with a little CaCl2 and distilled [Baltzly et al. J Am Chem Soc 77 2522 1955]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 165o. [Beilstein 6 IV 2035.]

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.

Waste Disposal

Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.

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View Lastest Price from m-Cresol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
m-Cresol pictures 2023-11-30 m-Cresol
108-39-4
US $0.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
m-Cresol pictures 2023-11-25 m-Cresol
108-39-4
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
m-Cresol pictures 2023-09-06 m-Cresol
108-39-4
US $30.00-10.00 / KG 50KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • m-Cresol pictures
  • m-Cresol
    108-39-4
  • US $0.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • m-Cresol pictures
  • m-Cresol
    108-39-4
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • m-Cresol pictures
  • m-Cresol
    108-39-4
  • US $30.00-10.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
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