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Methanol

Introduction Uses Methanol poisoning and First Aid Measures Production Toxicity Methanol gasoline
Methanol
Methanol
CAS No.
67-56-1
Chemical Name:
Methanol
Synonyms
CH3OH;metanol;ACID RED;S NO 250;Metanolo;Methylol;Carbinol;Methanol;ai3-00409;coat-b1400
CBNumber:
CB7854099
Molecular Formula:
CH4O
Formula Weight:
32.04
MOL File:
67-56-1.mol

Methanol Properties

Melting point:
-98 °C(lit.)
Boiling point:
65.4 °C(lit.)
Density 
0.791 g/mL at 25 °C
vapor density 
1.11 (vs air)
vapor pressure 
410 mm Hg ( 50 °C)
refractive index 
n20/D 1.329(lit.)
Flash point:
52 °F
storage temp. 
Store at RT.
solubility 
benzene: miscible(lit.)
pka
15.2(at 25℃)
form 
Liquid Free From Particulates
color 
<10(APHA)
Relative polarity
0.762
explosive limit
5.5-44%(V)
Water Solubility 
miscible
Merck 
14,5957
BRN 
1098229
CAS DataBase Reference
67-56-1(CAS DataBase Reference)
NIST Chemistry Reference
Methyl alcohol(67-56-1)
EPA Substance Registry System
Methanol(67-56-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  10-20/21/22-68/20/21/22-39/23/24/25-23/24/25-11-40-36-36/38-23/25
Safety Statements  36/37-7-45-16-24/25-23-24-26
RIDADR  UN 1170 3/PG 2
WGK Germany  1
RTECS  PC1400000
3-10
TSCA  Yes
HazardClass  3
PackingGroup  II
Hazardous Substances Data 67-56-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Methanol price More Price(194)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1.00837 Methanol 67-56-1 1EA $43.25 2017-11-08 Buy
Sigma-Aldrich 1.00837 Methanol 67-56-1 2EA $90 2017-11-08 Buy
TCI Chemical M0097 Methanol [for Spectrophotometry] >99.8%(GC) 67-56-1 500mL $24 2017-11-08 Buy
TCI Chemical M0628 Methanol [for HPLC Solvent] >99.8%(GC) 67-56-1 500mL $21 2017-11-08 Buy
Alfa Aesar 19393 Methanol, Semiconductor Grade, 99.9% min 67-56-1 1L $45.7 2017-11-08 Buy

Methanol Chemical Properties,Uses,Production

Introduction

Methanol is the simplest fatty alcohol. It is a colorless, flammable, irritating liquid with a boiling point of 64.7°C, a melting point of -93.90°C, and a relative density of 0.7913. Soluble in water and most organic solvents. Its severe toxicity can damage the optic nerve. Once swallowed, it can make the eyes blind and even cause death.
Methanol has the general properties of a primary aliphatic alcohol. The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. Therefore, it is largely used in the synthesis of formaldehyde. Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and methylamine, and it is also applied as important organic solvents, extraction agents and alcohol denaturants.

Uses

Methanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce acetic anhydride. It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in medicine and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester.
Industry Applications Role/Benefit
Laboratory HPLC, UV/VIS spectroscopy, and LCMS Low UV cutoff
Chemical manufacture Production of formaldehyde and its derivates Main feedstock
Production of hydrocarbon chains and even aromatic systems Main feedstock
Production of methyl tert-butyl ether Methylation reagent
Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester Main feedstock
Plastics Production of polymers Main feedstock
Farm chemical Production of insecticide and acaricide Main feedstock
Pharmaceuticals Production of sulfonamides, amycin, etc Main feedstock
Fuel for vehicles Pure methanol fuel Pure methanol does not produce an opaque cloud of smoke in the event of an accident
Methanol gasoline Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline
Chemical analysis Determination of boron Analysis agent
Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine Analysis agent
Others Separation of calcium sulfate and magnesium sulfate Separation reagent
Separation of strontium bromide and barium bromide Separation reagent
Anti-freezing agent Effective component

Methanol poisoning and First Aid Measures

Pathogenesis
First, methanol has a cumulative effect and is oxidized in the body into more toxic formaldehyde and formic acid. Methanol and its oxides directly damage the tissues, causing cerebral edema, meningeal hemorrhage, optic nerve and retinal atrophy, pulmonary congestion and edema, and hepatic and renal turbid swelling.
Second, methanol and its oxides cause blood circulation disorder, coenzyme system obstacles in vivo, resulting in lack of oxygen supply to the brain cortical cells, metabolic disorders, and related neurological and psychiatric symptoms.
Third, methanol oxidation products combine with the iron in the cytochrome oxidase, which inhibits the intracellular oxidation process thus causing metabolic disorders, acidosis along with organic acid accumulation in the body, and nerve cells impair.

Treatment Symptoms and treatments:
Acute pain morphine, pethidine
Convulsions phenobarbital, amimystrine, diazepam
Coma caffeine sodium benzoate
Respiratory failure nikethamide, theophylline

Production

   
If the conditions are strictly controlled, the yield can reach 100% and the purity can reach 99%.

Toxicity

ADI is limited to GMP (FAO/WHO, 2001).
Toxic, can cause blindness.
LD50: 5628 mg/kg (rat, oral).
 
Measurement Date System Route/Organism Dose Effect
Skin and Eye Irritation December 2016   eye /rabbit 40 mg moderate
Skin and Eye Irritation December 2016   eye /rabbit 100 mg/24H moderate
Skin and Eye Irritation December 2016   skin /rabbit 20 mg/24H moderate
Mutation Data December 2016 Cytogenetic Analysis parenteral/grasshopper 3000 ppm  
Mutation Data December 2016 Cytogenetic Analysis oral/mouse 1 gm/kg  
Mutation Data December 2016 Cytogenetic Analysis intraperitoneal/mouse 75 mg/kg  
Mutation Data December 2016 DNA Damage oral/rat 10 µmol/kg  
Mutation Data December 2016 DNA inhibition lymphocyte/human 300 mmol/L  
Mutation Data December 2016 DNA repair /Escherichia coli 20 mg/well  
Mutation Data December 2016 morphological transform fibroblast/mouse 0.01 mg/L/21D (-enzymatic activation step)  
from The National Institute for Occupational Safety and Health - NIOSH

Methanol gasoline

Methanol gasoline refers to the M series mixture fuel made of addition of methanol to the gasoline and formulated using methanol fuel solvent. Among them, M15 (add 15% methanol in gasoline) clean methanol gasoline is used as vehicle fuel, respectively, used in a variety of gasoline engines. It can be applied to substitute the finished gasoline without changing the existing engine structure, and can also be mixed with refined oil. The methanol mixed fuel has excellent thermal efficiency, power, start-up and being economical. It is also characterized by lowering the emissions, saving oil and being safe and convenient. Methanol gasoline types of M35, M15, M20, M50, N85 and M100 with different blend ratios have been developed around the world according to the conditions of different countries. At present, the commercial methanol is mainly M85 (85% methanol + 15% gasoline) and M100 with M100 performance being better than M85 and having greater environmental advantages.

Uses

Meets ACS specifications

Uses

Suitable for HPLC, spectrophotometry, and some LC-MS applications

Uses

high purity grade for ICP-MS detection

Uses

Suitable for volatile organics analysis by GC-MS

Definition

ChEBI: The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.

Uses

Industrial solvent. Raw material for making formaldehyde and methyl esters of organic and inorganic acids. Antifreeze for automotive radiators and air brakes; ingredient of gasoline and diesel oil antifreezes. Octane booster in gasoline. As fuel for picnic stoves and soldering torches. Extractant for animal and vegetable oils. To denature ethanol. Softening agent for pyroxylin plastics. Solvent and solvent adjuvant for polymers. Solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals.

General Description

A colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Completely mixes with water. The vapors are slightly heavier than air and may travel some distance to a source of ignition and flash back. Any accumulation of vapors in confined spaces, such as buildings or sewers, may explode if ignited. Used to make chemicals, to remove water from automotive and aviation fuels, as a solvent for paints and plastics, and as an ingredient in a wide variety of products.

Reactivity Profile

Methanol reacts violently with acetyl bromide [Merck 11th ed. 1989]. Mixtures with concentrated sulfuric acid and concentrated hydrogen peroxide can cause explosions. Reacts with hypochlorous acid either in water solution or mixed water/carbon tetrachloride solution to give methyl hypochlorite, which decomposes in the cold and may explode on exposure to sunlight or heat. Gives the same product with chlorine. Can react explosively with isocyanates under basic conditions. The presence of an inert solvent mitigates this reaction [Wischmeyer 1969]. A violent exothermic reaction occurred between methyl alcohol and bromine in a mixing cylinder [MCA Case History 1863. 1972]. A flask of anhydrous lead perchlorate dissolved in Methanol exploded when Methanol was disturbed [J. Am. Chem. Soc. 52:2391. 1930]. P4O6 reacts violently with Methanol. (Thorpe, T. E. et al., J. Chem. Soc., 1890, 57, 569-573). Ethanol or Methanol can ignite on contact with a platinum-black catalyst. (Urben 1794).

Health Hazard

Exposure to excessive vapor causes eye irritation, head- ache, fatigue and drowsiness. High concentrations can produce central nervous system depression and optic nerve damage. 50,000 ppm will probably cause death in 1 to 2 hrs. Can be absorbed through skin. Swallowing may cause death or eye damage.

Fire Hazard

Behavior in Fire: Containers may explode.

Methanol Preparation Products And Raw materials

Raw materials

Preparation Products


Methanol Suppliers

Global( 398)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20810 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96817 76
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3475911745
021-57711696 mkt@spectrumchina.net China 9824 60
Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 shenlinxing@macklin.cn China 13251 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44192 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25120 65
Yonghua Chemical Technology (Jiangsu) Co., Ltd. +86-512-5254 9999 To 852
+86-512-5254 6337 chenshuping@yonghuachem.com China 686 60

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