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Ivabradine hydrochloride

Ivabradine hydrochloride structure

CAS No.: 148849-67-6

Chemical Name:: Ivabradine hydrochloride

Synonyms: Ivabradine HCl;Procoralan;Ivabradine hydrochlorid;CS-774;S-16257;Corlentor;S 16257-2;2H-3-Benzazepin-2-on;Ivabridine hydracloride;Ivabradine hydrochloride

CBNumber:: CB81006694

Molecular Formula:: C27H37ClN2O5

Molecular Weight:: 505.05

MDL Number:: MFCD00929899

MOL File:: 148849-67-6.mol

MSDS File:: SDS

Last updated:2024-03-18 17:23:41

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Ivabradine hydrochloride Properties

Melting point	193-196?C
alpha	58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp.	2-8°C
solubility	H2O: ≥5mg/mL (warmed)
form	powder
color	white to beige
optical activity	[α]/D +5 to +9°, c = 1 in DMSO
Merck	14,5247
InChIKey	HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES	C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl \|&1:1,r\|
CAS DataBase Reference	148849-67-6(CAS DataBase Reference)
FDA UNII	TP19837BZK
NCI Drug Dictionary	ivabradine hydrochloride

Pharmacokinetic data

Protein binding	70%
Excreted unchanged in urine	4%
Volume of distribution	100 Litres
Biological half-life	2 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HS Code	2933.79.1500

Ivabradine hydrochloride price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0281	Ivabradine hydrochloride ≥98% (HPLC)	148849-67-6	10mg	$93.4	2024-03-01	Buy
Sigma-Aldrich	SML0281	Ivabradine hydrochloride ≥98% (HPLC)	148849-67-6	50mg	$380	2024-03-01	Buy
TCI Chemical	I0847	Ivabradine Hydrochloride >98.0%(HPLC)(N)	148849-67-6	1g	$771	2024-03-01	Buy
TCI Chemical	I0847	Ivabradine Hydrochloride >98.0%(HPLC)(N)	148849-67-6	200mg	$229	2024-03-01	Buy
Cayman Chemical	15868	Ivabradine (hydrochloride) ≥95%	148849-67-6	10mg	$73	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0281	10mg	$93.4	Buy
SML0281	50mg	$380	Buy
I0847	1g	$771	Buy
I0847	200mg	$229	Buy
15868	10mg	$73	Buy

Ivabradine hydrochloride Chemical Properties,Uses,Production

Description

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

Chemical Properties

White to Off-White Solid

Originator

Servier (France)

Uses

angina therapeutic

Uses

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent

Uses

Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal

Uses

Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).

Definition

ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.

brand name

Procoralan

Biochem/physiol Actions

Ivabradine is used to treat chronic heart failure.

Clinical Use

Symptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm Treatment of mild to severe chronic heart failure

storage

Store at -20°C

Ivabradine hydrochloride synthesis

Synthesis of Ivabradine hydrochloride from 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one

Ivabradine hydrochloride Preparation Products And Raw materials

Raw materials

3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

Preparation Products

Ivabradine hydrochloride Suppliers

Global( 446)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Joyochem Co.,Ltd	+86-0531-82687558 +8613290333633	sales@joyochem.com	China	42	58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	+86-010-83386758 +86-18810831598	jennifer@lianben.com	China	85	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	+undefined-0518-86098006 +undefined19851887368	lvan.hui@jsytsw.com	China	80	58
Chengdu ChenLv Herb Co.,Ltd	+undefined13608205856	maryextract@126.com	China	127	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Shanghai Affida new material science and technology center	+undefined15081010295	2691956269@qq.com	China	359	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55

Supplier	Advantage
Joyochem Co.,Ltd	58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	58
Chengdu ChenLv Herb Co.,Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Ruihan Technology Co., Ltd	58
Shanghai Affida new material science and technology center	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55

View Lastest Price from Ivabradine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-18	Ivabradine hydrochloride 148849-67-6	US $0.00-0.00 / KG	1KG	99	10 tons	Shanghai Affida new material science and technology center
2023-12-19	Ivabradine hydrochloride 148849-67-6	US $0.00-0.00 / kg	1kg	99%	50000kg	Hebei Yibangte Import and Export Co. , Ltd.
2023-10-21	Ivabradine hydrochloride 148849-67-6	US $50.00 / kg	1kg	0.99	10000	Hebei Yanxi Chemical Co., Ltd.

Ivabradine hydrochloride
148849-67-6
US $0.00-0.00 / KG
99
Shanghai Affida new material science and technology center

Ivabradine hydrochloride
148849-67-6
US $0.00-0.00 / kg
99%
Hebei Yibangte Import and Export Co. , Ltd.

Ivabradine hydrochloride
148849-67-6
US $50.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

Ivabradine hydrochloride Spectrum

Ivabradine hydrochloride(148849-67-6)¹HNMR

148849-67-6(Ivabradine hydrochloride)Related Search:

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3-Chloropropyltrimethoxysilane Tribenuron methyl 3-Chloropropyltriethoxysilane 3-Aminopropyltriethoxysilane Ivabradine

1-AdaMantanethylaMine Polyethylene Glycol 4,4,5A-TRIMETHYLPERHYDRO-1-BENZOXIREN-2-ONE

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Ivabradine hydrochloride 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride Ivabradine hydrochloride, >=99% IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride Corlentor S-16257 (7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride 2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride 2H-3-Benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)- Ivabridine hydracloride 2H-3-Benzazepin-2-one,3-[3-[[[(7S)-3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-,hydrochloride (1:1) 3-[3-[[(3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-, Monohydrochloride 2H-3-Benzazepin-2-on Ivabradine HCl (Procoralan) (S)-3-(3-(((3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl)(Methyl)aMino)propyl)-7,8-diMethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride S 16257-2 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,hydrochloride (1:1) Ivabradine hydrochloride, 98%, a If inhibitor lvabradine hydrochloride CS-774 IvabradineHydrochloride> Ivabradine hydrochloride USP/EP/BP Ivabradine Hydrochloride Impurities (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride Ivabradine HydrochlorideQ: What is Ivabradine Hydrochloride Q: What is the CAS Number of Ivabradine Hydrochloride Q: What is the storage condition of Ivabradine Hydrochloride Q: What are the applications of Ivabradine Hydrochloride Ivabradine HCl Procoralan Ivabradine hydrochlorid 2-Propen-1-one,1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-,(6E)- (S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride 148849-67-6 Ivabradine Hydrochloride (S)-3-(3-(((4,5-dimethoxy-1,2 dihydrocyclobutabenzen1yl)methyl)(methyl)amino)propyl)-7,8- dimethoxy-4,5-dihydro-1Hbenzo[d]azepin-2(3H)-one hydrochloride 148849-67-6 148849-54-6 48849-67-6 1448849-67-6 C27H37ClN2O5 C27H36N2O5HCl Chiral Reagents Heterocycles API Cardiovascular APIs Intermediates & Fine Chemicals Pharmaceuticals Inhibitors