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ChemicalBook >> CAS DataBase List >>2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-

2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-

2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Structure
2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- structure
CAS No.
2407654-51-5
Chemical Name:
2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
Synonyms
ZXH-1-161;3-(4-((2-((2,3-dihydro-1H-inden-5-yl)amino)pyrimidin-4-yl)amino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
CBNumber:
CB812014215
Molecular Formula:
C26H24N6O3
Molecular Weight:
468.51
MDL Number:
MOL File:
2407654-51-5.mol
Last updated:2023-04-23 13:52:06
Request For Quotation

2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Properties

Density 1.451±0.06 g/cm3(Predicted)
solubility DMSO : 250 mg/mL (533.61 mM; Need ultrasonic)
pka 10.70±0.40(Predicted)

2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Chemical Properties,Uses,Production

Biological Activity

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1].

References

[1]. Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730.

2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1304 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725 malulu@leyan.com China 55023 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 9957 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4164 58
Supplier Advantage
Jilin Province Woda Biotechnology Co., Ltd. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
TargetMol Chemicals Inc. 58
Henan Alpha Chemical Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
2,6-Piperidinedione, 3-[4-[[2-[(2,3-dihydro-1H-inden-5-yl)amino]-4-pyrimidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- ZXH-1-161 3-(4-((2-((2,3-dihydro-1H-inden-5-yl)amino)pyrimidin-4-yl)amino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2407654-51-5