Pal-Tripeptide-1
- CAS No.
- 147732-56-7
- Chemical Name:
- Pal-Tripeptide-1
- Synonyms
- Pal-AHK;L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-;Pal-GHK-OH;Collaxyl II;Palmitoyl-GHK;Pal-GHK, >=95%;Pal-Tripeptide-1;Palm-Gly-His-Lys;Peptides PAL-Ghk;PAL-GLY-HIS-LYS-OH
- CBNumber:
- CB81214020
- Molecular Formula:
- C30H54N6O5
- Molecular Weight:
- 578.79
- MDL Number:
- MFCD18251733
- MOL File:
- 147732-56-7.mol
| Boiling point | 913.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.105 |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml |
| form | A solid |
| pka | 3.16±0.10(Predicted) |
| Sequence | Pal-Gly-His-Lys |
| InChIKey | BYUQATUKPXLFLZ-UIOOFZCWSA-N |
| SMILES | C(O)(=O)[C@H](CCCCN)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CNC(=O)CCCCCCCCCCCCCCC |
| FDA UNII | RV743D216M |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Pal-Tripeptide-1 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27059 | Pal-GHK | 147732-56-7 | 100mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 27059 | Pal-GHK | 147732-56-7 | 250mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 27059 | Pal-GHK | 147732-56-7 | 500mg | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 27059 | Pal-GHK | 147732-56-7 | 1g | $384 | 2024-03-01 | Buy |
| TRC | P161025 | PalmitoylTripeptide-1 | 147732-56-7 | 250mg | $100 | 2021-12-16 | Buy |
Pal-Tripeptide-1 Chemical Properties,Uses,Production
Description
A peptide is two or more amino acids joined together and is the building block of protein. Peptides fall into three main categories: signal peptides, carrier peptides, and those that inhibit nerve signals. Signal peptides, like palmitoyl tripeptide-1, act as messengers to cells, which trigger collagen synthesis, which then increases skin firmness.Palmitoyl tripeptide-1 is a small three amino acid signal peptide with the amino sequence of glycine-histidine-lysine (GHK). GHK is attached to palmitic acid (a fatty acid) to increase its skin penetration and oil solubility.
Description
Pal-GHK is a form of the extracellular matrix-derived peptide GHK containing palmitic acid , which allows it to penetrate the stratum corneum to the epidermal and dermal skin layers. Pal-GHK (0.5 μM) increases collagen synthesis in human skin fibroblasts in vitro. It reduces collagen degradation ex vivo in patient-derived human skin samples irradiated with UVA light when used at a concentration of 6 ppm. It has been used with the zwitterionic surfactant C12 dodecyldimethylamine oxide (C12DMAO) to study self-assembly of the mixture into aggregates, ribbons, and nanobelts. Pal-GHK has also been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS.
Uses
Palmitoyl Tripeptide-1, has shown to have effects on on collagen, fibronectin, hyaluronic acid synthesis in human dermal fibroblasts, and thus can be used in preparation of antiaging cosmetic creams.
Application
Palmitoyl Tripeptide-1 (Pal-GHK, SpecPed? PT1P) is useful in anti-aging products and wrinkle treatment products such as gels, serums, lotions and creams. Acting as messengers of cutaneous restructuration and repair, this peptide works synergistically to restore and maintain the skin's youthful appearance.
Clinical Use
Applying palmitoyl tripeptide-1 directly to your skin tells the cells to make more collagen, stimulating new collagen production. It requires at least one month or more to begin to see visible changes from new collagen with maximum results visible after 3 to 4 months. Erin Gilbert, MD, FAAD, Ph.D., and board-certified dermatologist and neuroscientist, continues: "Peptides can be included in serums, moisturizers, and masks," Gilbert explains. "They are also included in some topical serums used after micro-needling or superficial laser procedures to increase the penetration of the peptide and help the skin recover from the procedure."
Safety
The CIR Expert Panel concluded that peptides, such as palmitoyl tripeptide-1, are safe in cosmetics and self-care products. Environmental Working Group (EWG) currently scores palmitoyl tripeptide-1 as “1” or “low hazard.”Overall, peptides, such as palmitoyl tripeptide-1, mimic what already exists in the human body and research on peptides’ impact on the skin shows limited to no skin irritation. In terms of toxicity caused by peptides, there is no published research to document any known toxicity.
Pal-Tripeptide-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
| Hantai Biomedical Group Co. LTD | +8618819265912 | id002@cnhantide.com | China | 37 | 58 |
| Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 64 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6711 | 58 |
| Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 874 | 58 |
| Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 | sales@cellwh.com | China | 376 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Related articles
- Pal-Tripeptide-1: Anti-Oxidative Potential and Mechanism of Action
- Pal-Tripeptide-1 enhances collagen, skin elasticity, and reduces wrinkles effectively, with superior antioxidant properties, m....
- Mar 21，2024
- The introduction of Pal-Tripeptide-1
- PalMitoyl Tripeptide-1(Pal-GHK) is a white powder. This substance is always being used in cosmetic products.
- Oct 20，2023
View Lastest Price from Pal-Tripeptide-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | PAL GHK
147732-56-7
|
US $200.00-180.00 / Box | 1Box | 99% | 40000 | Hebei Weimiao Import and Export Trade Co., Ltd. | |
 |
2024-04-23 | Palmitoyl Tripeptide-1/Palmitoyl-Oligopeptide
147732-56-7
|
US $30.00 / Box | 1Box | 99.99% | 10000000000 | zhuzhou dingcheng meihei comestic co.,ltd | |
 |
2024-04-23 | Palmitoyl Tripeptide-1, Pal-GHK
147732-56-7
|
US $220.00-210.00 / kg | 0.1kg | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd |
-
- PAL GHK
147732-56-7
- US $200.00-180.00 / Box
- 99%
- Hebei Weimiao Import and Export Trade Co., Ltd.
-
- Palmitoyl Tripeptide-1/Palmitoyl-Oligopeptide
147732-56-7
- US $30.00 / Box
- 99.99%
- zhuzhou dingcheng meihei comestic co.,ltd
-
- Palmitoyl Tripeptide-1, Pal-GHK
147732-56-7
- US $220.00-210.00 / kg
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd