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IBERIOTOXIN

IBERIOTOXIN structure

CAS No.: 129203-60-7

Chemical Name:: IBERIOTOXIN

Synonyms: IBTX;RLBTX;IBERIOTOXIN;IBERIOTOXIN 98%;Iberiotoxin Standard;IBERIOTOXIN USP/EP/BP;IBERIOTOXIN, RECOMBINANT;IBERIOTOXIN, BUTHUS TAMULUS;129203-60-7/182897-30-9（TFA);M.W. 4230.91 C179H274N50O55S7

CBNumber:: CB8130448

Molecular Formula:: C179H274N50O55S7

Molecular Weight:: 4230.84786

MDL Number:: MFCD00131365

MOL File:: 129203-60-7.mol

Last updated:2023-06-30 15:45:59

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IBERIOTOXIN Properties

storage temp.	-20°C
solubility	H₂O: 1 mg/mL, clear, colorless
form	Salt-free lyophilized solid
Water Solubility	Soluble to 0.70 mg/ml in water
EWG's Food Scores	1
FDA UNII	773HER9B6T

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Symbol(GHS)	GHS06
Signal word	Danger
Signal word	Danger
Hazard statements	H300+H310+H330
Hazard statements	H300+H310+H330
Precautionary statements	P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
Precautionary statements	P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	28-36/37-45
RIDADR	UN 3462 6.1/PG 2
WGK Germany	3
RTECS	NH6107500
F	3-10

IBERIOTOXIN price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	401002	Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem	129203-60-7	10μg	$265	2024-03-01	Buy
Sigma-Aldrich	I5904	Iberiotoxin, recombinant from Mesobuthus tamulus ≥98% (HPLC), recombinant, expressed in E. coli	129203-60-7	5μG	$108	2023-06-20	Buy
Sigma-Aldrich	I5904	Iberiotoxin, recombinant from Mesobuthus tamulus ≥98% (HPLC), recombinant, expressed in E. coli	129203-60-7	10μG	$184	2023-06-20	Buy
Sigma-Aldrich	I5904	Iberiotoxin, recombinant from Mesobuthus tamulus ≥98% (HPLC), recombinant, expressed in E. coli	129203-60-7	100μG	$541	2023-06-20	Buy
Tocris	1086	Iberiotoxin	129203-60-7	100U	$333	2021-12-16	Buy

Product number	Packaging	Price	Buy
401002	10μg	$265	Buy
I5904	5μG	$108	Buy
I5904	10μG	$184	Buy
I5904	100μG	$541	Buy
1086	100U	$333	Buy

IBERIOTOXIN Chemical Properties,Uses,Production

Uses

Iberiotoxin is a selective and reversible inhibitor of high-conductance calcium-activated potassium channel. A toxin purified from the Eastern Indian red scorpion Buthus tamulus.

Uses

Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K⁺ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca²⁺- activated K⁺ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.

Uses

Selective probe for high-conductance calcium-activated potassium channels.

Biological Activity

iberiotoxin is a 37 amino acid peptidyl toxin isolated from the scorpion mesobuthus tamulus and was shown to selectively block large conductance ca2+-activated k+ channels(bkca) in smooth muscle cells.in single channel recordings, iberiotoxin can reversibly block outward currents mediated by bkca in excised membrane patches from bovine aortic smooth muscle with an ic50 value of 250 pm. it is also a noncompetitive, partial inhibitor of charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (ki = 250 pm).[1]. galvez a, gimenez-gallego g, reuben j p, et al. purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion buthus tamulus. the journal of biological chemisty, 1990, 265(19): 11083-11090.

Biochem/physiol Actions

The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.

storage

-20°C (desiccate)

IBERIOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

IBERIOTOXIN Suppliers

Global( 79)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Hefei KS-V Peptide Biotechnology Co., Ltd.	0551-65120828 17368858770	sales1@difficultpeptide.com	China	118	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Chengdu Youngshe Chemical Co., Ltd.	58
LEAP CHEM CO., LTD.	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58
Aladdin Scientific	58
Hefei KS-V Peptide Biotechnology Co., Ltd.	58

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PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN iberiotoxin from buthus tamulus IBERIOTOXIN, RECOMBINANT IBERIOTOXIN 98% PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH PYR-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN-OH (DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35) M.W. 4230.91 C179H274N50O55S7 pGlu-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH Iberiotoxin, recombinant from Mesobuthus tamulus IBERIOTOXIN FROM BUTHUS TAMULUS, 50 UG* IBTX IBTX (SCORPION, BUTHUS TAMULUS) IBERIOTOXIN IBERIOTOXIN, BUTHUS TAMULUS IBERIOTOXIN SCORPION BUTHUS TAMULUS PGLU-PHE-THR-ASP-VAL-ASP-CYS-SER-VAL-SER-LYS-GLU-CYS-TRP-SER-VAL-CYS-LYS-ASP-LEU-PHE-GLY-VAL-ASP-ARG-GLY-LYS-CYS-MET-GLY-LYS-LYS-CYS-ARG-CYS-TYR-GLN [DISULFIDE BRIDGES: 7-28, 13-3, 17-3] RLBTX PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ PYR-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(DISULFIDE BRIDGE: C7-C28,C13-C33,C17-C35) Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem IBERIOTOXIN USP/EP/BP Iberiotoxin Standard 129203-60-7/182897-30-9（TFA) 129203-60-7 C179H274N50O55S7 C179H273N49O56S7 Voltage-gated Ion Channels Potassium Channel Modulators Other Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Type Monovalent Ion Channels Ion Channels BioChemical Biochemicals and Reagents Cell Biology Cell Signaling and Neuroscience Enzyme Inhibitors Enzyme Inhibitors by Type Other Potassium channel Ion Channel Modulating Peptides Potassium Channel ModulatorsPeptides for Cell Biology Monovalent Ion Channels Potassium Channel ModulatorsCell Signaling and Neuroscience Scorpion Toxins and Venoms Voltage-gated Ion Channels