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Aminophylline

Description References

CAS No.317-34-0
Chemical Name:Aminophylline
Synonyms:dobo;carena;th/100;lasodex;tefamin;theomin;aminodur;cariomin;eufilina;euufilin
CBNumber:CB8145350
Molecular Formula:2C7H8N4O2.C2H8N2
Formula Weight:420.43
MOL File:317-34-0.mol
Aminophylline Property
Melting point : 269-270 °C
storage temp. : −20°C
solubility : H2O: 3.7 mg/mL solutions should be freshly prepared.
form : powder
color : white to off-white
Water Solubility : soluble
Merck : 13,464
CAS DataBase Reference: 317-34-0(CAS DataBase Reference)
EPA Substance Registry System: 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)(317-34-0)
Safety
Hazard Codes : Xn,C
Risk Statements : 22-42/43-34-36/37/38-20/21/22
Safety Statements : 45-36/37/39-26-23-36
RIDADR : UN 2811 6.1/PG 3
WGK Germany : 3
RTECS : XH5600000
F : 10-23
TSCA : Yes
HazardClass : 6.1(b)
PackingGroup : III
Hazardous Substances Data: 317-34-0(Hazardous Substances Data)

Aminophylline Chemical Properties,Usage,Production

Description
Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.
References
https://www.drugbank.ca/drugs/DB01223 https://en.wikipedia.org/wiki/Aminophylline
Chemical Properties
white to slightly yellowish powder
Uses
Bronchodilatator;Mastocytes degranulation inhibitor
Uses
Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
Aminophylline Preparation Products And Raw materials
Raw materials
Mixer Theophylline
Preparation Products
Aminophylline Suppliers      Global( 178)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3226 55
Boen pharm 86 512-62572107 62962707
86 512-62922078sales@boenpharm.com China 803 58
Yichang Yongnuo Pharmaceutical Co., Ltd. 15572799336/0717-4128488
0717-4460150sales@yongnuopharm.com;334072254@qq.com China 2419 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.com China 96832 76
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763sales@hwrkchemical.com China 15555 55
Adamas Reagent, Ltd. 400-600-9262
021-51701678mc@titansci.com China 14021 59
LGM Pharma 1-(800)-881-8210
615-250-9817inquiries@lgmpharma.com United States 1970 70
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32539 50
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145sales02@farchem.com China 9241 52
Chengdu XiYa Chemical Technology Co., Ltd. 4008-626-111
028-84752058sale@xiyashiji.com China 9747 57
 
317-34-0(Aminophylline)Related Search:
Dimethyl ether N-(1-Naphthyl)ethylenediamine dihydrochloride LSD Ethylenediamine dihydrochloride Dimethyl phthalate 2-[(4-AMINO-PHENYL)-ETHYL-AMINO]-ETHANOL 2-(2-Aminoethylamino)ethanol Ethylenediamine Purine Dimethyl fumarate Dimethyl sulfoxide 2,6-Dimethyl-7-octen-2-ol Theophylline N,N,N',N'-Tetramethylethylenediamine AMIROPHYLLINE 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Theophylline, 7-(3-(4-benzyl-1-piperazinyl)propyl)-, dihydrochloride Acefylline Piperazine
317-34-0 BioChemical Cell Signaling and Neuroscience Cell Biology AMINOPHYLLINE Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides THEOPHYLLINE COMPOUND WITH ETHYLENEDIAMINE THEOPHYLLINE ETHYLENEDIAMINE 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine( 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compdwith1,2-ethanediamine(2 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dionecompd.with1,2-ethanediamine(2 aminocadol aminocardol aminodur aminofilina aminophyllin Amminofillina ammophyllin cardiofilina cardiomin cardophylin cardophyllin carena cariomin diaphylline diophllin diophyllin diuxanthine dobo dura-tabs.m.aminophylline dura-tabsmaminophylline ethophylline ethylenediamine,compd.withtheophylline(1:2) etilen-xantisantabl etilen-xantisantabl. eufilina euphyllin euphylline eurphyllin euufilin euufillin genophyllin grifomin inophylline lasodex linampheta metaphyllin metaphylline methophylline minaphil miofilin neophyiline neophylline norofilina peterphyllin
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