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Aminophylline

Description References
Aminophylline
Aminophylline
CAS No.
317-34-0
Chemical Name:
Aminophylline
Synonyms
dobo;carena;th/100;lasodex;tefamin;theomin;aminodur;cariomin;eufilina;euufilin
CBNumber:
CB8145350
Molecular Formula:
2C7H8N4O2.C2H8N2
Formula Weight:
420.43
MOL File:
317-34-0.mol

Aminophylline Properties

Melting point:
269-270 °C
storage temp. 
−20°C
solubility 
H2O: 3.7 mg/mL solutions should be freshly prepared.
form 
powder
color 
white to off-white
Water Solubility 
soluble
Merck 
14,465
CAS DataBase Reference
317-34-0(CAS DataBase Reference)
EPA Substance Registry System
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)(317-34-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,C
Risk Statements  22-42/43-34-36/37/38-20/21/22
Safety Statements  45-36/37/39-26-23-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  XH5600000
10-23
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 317-34-0(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Aminophylline price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A1755 Aminophylline ≥98%, powder 317-34-0 25g $47.8 2017-11-08 Buy
Sigma-Aldrich A1755 Aminophylline ≥98%, powder 317-34-0 100g $83.7 2017-11-08 Buy
TCI Chemical A2805 Aminophylline >98.0%(HPLC) 317-34-0 25g $24 2017-12-01 Buy
TCI Chemical A2805 Aminophylline >98.0%(HPLC) 317-34-0 100g $64 2017-12-01 Buy
Alfa Aesar J60705 Aminophylline, anhydrous, 98% 317-34-0 25g $34.3 2017-11-08 Buy

Aminophylline Chemical Properties,Uses,Production

Description

Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.

References

https://www.drugbank.ca/drugs/DB01223 https://en.wikipedia.org/wiki/Aminophylline

Chemical Properties

white to slightly yellowish powder

Uses

Bronchodilatator;Mastocytes degranulation inhibitor

Uses

Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.

Aminophylline Preparation Products And Raw materials

Raw materials

Preparation Products


Aminophylline Suppliers

Global( 196)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
027-83214668 bruce@xrdchem.cn CHINA 509 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20810 55
Mainchem Co., Ltd.
0592-6210733
0592-6210733 sales@mainchem.com CHINA 3270 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1410 55
Boen pharm 86 512-62572107 62962707
86 512-62922078 sales@boenpharm.com China 803 58
Yichang Yongnuo Pharmaceutical Co., Ltd. 15571779144/0717-4128488
0717-4460150 sales@yongnuopharm.com;653914859@qq.com China 2410 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96819 76
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 14018 59
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1960 70

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