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2-Bromo-3-methylthiophene

2-Bromo-3-methylthiophene Structure
2-Bromo-3-methylthiophene structure
CAS No.
14282-76-9
Chemical Name:
2-Bromo-3-methylthiophene
Synonyms
2B3MT;178.04;TH1-Br;2-Bromo-3-methylthio;2-bromo-3-methyltiophene;3-Methyl-2-bromothiophene;2-BROMO-3-METHYLTHIOPHENE;Thiophene,2-bromo-3-methyl-;2-Bromo-3-methylthiophene>2-Bromo-3-methylthiophene 97%
CBNumber:
CB8147031
Molecular Formula:
C5H5BrS
Molecular Weight:
177.06
MDL Number:
MFCD00059741
MOL File:
14282-76-9.mol
MSDS File:
SDS
Last updated:2024-01-23 14:06:52
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2-Bromo-3-methylthiophene Properties

Melting point <25 °C
Boiling point 173-176 °C (lit.)
Density 1.572 g/mL at 25 °C (lit.)
refractive index n20/D 1.572(lit.)
Flash point 155 °F
storage temp. 2-8°C
solubility soluble in Chloroform, Ethyl Acetate
Water Solubility Insoluble in water
form liquid
Specific Gravity 1.580
color Pale yellow
BRN 105719
CAS DataBase Reference 14282-76-9(CAS DataBase Reference)
NIST Chemistry Reference Thiophene, 2-bromo-3-methyl-(14282-76-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  T,Xi,Xn
Risk Statements  25-41-43-36/37/38-20/21/22
Safety Statements  26-36/37/39-45
RIDADR  UN 2810
WGK Germany  3
Hazard Note  Harmful
HazardClass  IRRITANT-HARMFUL, KEEP COLD
HazardClass  6.1
PackingGroup  III
HS Code  29349990
NFPA 704
2
2 0

2-Bromo-3-methylthiophene price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 337021 2-Bromo-3-methylthiophene 95% 14282-76-9 1g $26.4 2023-06-20 Buy
Sigma-Aldrich 337021 2-Bromo-3-methylthiophene 95% 14282-76-9 5g $71.7 2023-06-20 Buy
TCI Chemical B1025 2-Bromo-3-methylthiophene >98.0%(GC) 14282-76-9 5g $44 2024-03-01 Buy
TCI Chemical B1025 2-Bromo-3-methylthiophene >98.0%(GC) 14282-76-9 25g $129 2024-03-01 Buy
Alfa Aesar L11393 2-Bromo-3-methylthiophene, 97% 14282-76-9 5g $53.65 2024-03-01 Buy
Product number Packaging Price Buy
337021 1g $26.4 Buy
337021 5g $71.7 Buy
B1025 5g $44 Buy
B1025 25g $129 Buy
L11393 5g $53.65 Buy

2-Bromo-3-methylthiophene Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

2-Bromo-3-methylthiophene was used in the preparation of poly(3,3′′′-dimethyl-(2,2′:5′,2′:5′,2′′′)tetrathiophene)). It was also used in the preparation of 2-bromo-3-(bromomethyl)thiophene, lachrymatory compound.

Application

2-Bromo-3-methylthiophene is used as a pharmaceutical intermediate. It is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.

Preparation

2-Bromo-3-methylthiophene synthesis: To a solution of glacial AcOH (100 mL), acetic anhydride (4.0 g, 0.039 mol), and 3-methylthiophene (9.82 g, 0.100 mol) as a stirred mixture was added NBS (19.6 g, 0.11 mol) in one portion with a slight exotherm to 44 oC. After 20 min the reaction mixture was poured onto ice, neutralized with sodium bisulfite and extracted with ether. The ether layer was washed with water and concentrated to give 11.3 g (64%) of 2-bromo-3-methylthiophene as a tan colored liquid in 88% purity by GC area % analysis: 1H NMR (CDCl3) d 7.1 (d, 1H, J=5.7 Hz), 6.7 (d, 1H, J=5.9 Hz), 2.2 (s, 3H).

General Description

2-Bromo-3-methylthiophene is formed (approx. 90%) by bromination of 3-methyl thiophene with N-bromosuccinimide in the absence of benzoyl peroxide.

2-Bromo-3-methylthiophene synthesis

128-08-5
616-44-4
14282-76-9
Synthesis of 2-Bromo-3-methylthiophene from N-Bromosuccinimide and 3-Methylthiophene

2-Bromo-3-methylthiophene Preparation Products And Raw materials

Raw materials

Acetic acid Acetic anhydride 3-Methylthiophene N-Bromosuccinimide

Preparation Products

3-METHYLTHIOPHENE-2-BORONIC ACID 2,3,5-Trimethylthiophene 3-METHYLTHIOPHENE-2-BORONIC ACID PINACOL ESTER 2-BROMOTHIOPHENE-3-CARBALDEHYDE 2-[(5-BROMO-2-THIENYL)CARBONYL]BENZENECARBOXYLIC ACID
4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone MTPPA

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2-Bromo-3-methylthiophene Suppliers

Global( 375)Suppliers
Supplier Tel Email Country ProdList Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
AB PharmaTech,LLC 		323-480-4688 United States 989 55
Supplier Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55

View Lastest Price from 2-Bromo-3-methylthiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-3-methylthiophene pictures 2024-04-19 2-Bromo-3-methylthiophene
14282-76-9
 US $5.00 / kg 1kg ≥99% 200mt/year Jinan Finer Chemical Co., Ltd
2-Bromo-3-methylthiophene pictures 2024-01-23 2-Bromo-3-methylthiophene
14282-76-9
 US $9.00-0.90 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-Bromo-3-methylthiophene pictures 2023-10-09 2-Bromo-3-methylthiophene
14282-76-9
 US $10.00-1.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.

2-Bromo-3-methylthiophene Spectrum

2-Bromo-3-methylthiophene(14282-76-9)MS2-Bromo-3-methylthiophene(14282-76-9)1HNMR2-Bromo-3-methylthiophene(14282-76-9)13CNMR2-Bromo-3-methylthiophene(14282-76-9)IR1

14282-76-9(2-Bromo-3-methylthiophene)Related Search:

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Thiophene,2-bromo-3-methyl- 2B3MT 2-BROMO-3-METHYLTHIOPHENE 2-Bromo-3-Methylthiophene99.5% 2-bromo-3-methyltiophene 2-Bromo-3-methylthiophene 97% 178.04 2-BROMO-3-METHYLTHIOPHENE 98+% 2-Bromo-3-methyl-thiophene ,97% 3-Methyl-2-bromothiophene 2-Bromo-3-methylthio 2 - broMine - 3 - Methyl thiophene 1-[2-[(2-BROMO-3-THIENYL)METHOXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE TH1-Br 2-Bromo-3-methylthiophene> 2-Bromo-3-methylthiophene ISO 9001：2015 REACH 14282-76-9 14282-75-9 C5H5Br Thiophenes Halogenated Heterocycles Heterocyclic Building Blocks ARYL HALIDE Building Blocks Thiophenes Thiophene&Benzothiophene Heterocycles Bromides blocks Thiophens Thiophene Organohalides Halogenated ThiophenesBuilding Blocks Heterocyclic Building Blocks Building Blocks C4 to C6 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Heterocycle-oher series Thiophene Series Halogenated Heterocycles