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TCPOBOP

TCPOBOP structure

CAS No.: 76150-91-9

Chemical Name:: TCPOBOP

Synonyms: TCPOBOP;3,3',5,5'-TETRACHLORIDE-BPB;TCPOBOP - CAS 76150-91-9 - Calbiochem;inhibit,Bcl-2 Family,TCPOBOP,Inhibitor;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene;3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE;1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene;3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene

CBNumber:: CB8155924

Molecular Formula:: C16H8Cl4N2O2

Molecular Weight:: 402.06

MDL Number:: MFCD00057368

MOL File:: 76150-91-9.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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TCPOBOP Properties

Boiling point	444.8±45.0 °C(Predicted)
Density	1.518±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >10 mg/mL
form	solid
pka	-0.52±0.10(Predicted)
color	white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
FDA UNII	P4R368GDD7

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3
RTECS	UT7145000

TCPOBOP price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T1443	TCPOBOP ≥98% (HPLC), solid	76150-91-9	5mg	$80.7	2024-03-01	Buy
Sigma-Aldrich	580563	TCPOBOP	76150-91-9	25mg	$124.8	2024-03-01	Buy
Cayman Chemical	14140	TCPOBOP ≥95%	76150-91-9	5mg	$44	2024-03-01	Buy
Cayman Chemical	14140	TCPOBOP ≥95%	76150-91-9	10mg	$78	2024-03-01	Buy
Cayman Chemical	14140	TCPOBOP ≥95%	76150-91-9	25mg	$151	2024-03-01	Buy

Product number	Packaging	Price	Buy
T1443	5mg	$80.7	Buy
580563	25mg	$124.8	Buy
14140	5mg	$44	Buy
14140	10mg	$78	Buy
14140	25mg	$151	Buy

TCPOBOP Chemical Properties,Uses,Production

Description

TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.

Uses

TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.

General Description

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.

Biochem/physiol Actions

TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.

References

1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893

TCPOBOP Preparation Products And Raw materials

Raw materials

Preparation Products

TCPOBOP Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 18521732826;	market@aladdin-e.com	China	25015	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
BOC Sciences	65
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Sigma-Aldrich	80
EMMX Biotechnology LLC	60

TCPOBOP Spectrum

TCPOBOP(76150-91-9)¹HNMR

76150-91-9(TCPOBOP)Related Search:

TYRPHOSTIN AG 879 AG 490 (+)-Camptothecin Brefeldin A TCPOBOP 580563, [3H]

TCPOBOP 580563 3-CHLORO-2-METHOXYPYRIDINE 3,5-Dichloropyridine 3,5-DICHLORO-2-PYRIDONE TCPOBOP

3-Chloropyridin-2-ol 5-Chloro-2-methoxypyridine 5-CHLORO-2-HYDROXYPYRIDINE

1of3

3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE 3,3',5,5'-TETRACHLORIDE-BPB 1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE TCPOBOP 2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene 1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene 1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene 2,2'-(4,1-Phenylenebisoxy)bis(3,5-dichloropyridine) 2,2'-(p-Phenylenebisoxy)bis(3,5-dichloropyridine) 2,2'-[Benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine) 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene TCPOBOP - CAS 76150-91-9 - Calbiochem 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene 3,5-dichloro-2-{4-[(3,5-dichloropyridin-2-yl)oxy]phenoxy}pyridine Pyridine, 2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro- inhibit,Bcl-2 Family,TCPOBOP,Inhibitor 76150-91-9 C16H8N2O2Cl4 C16H8Cl4N2O2 Apoptosis and Cell Cycle Cell Cycle Regulators Cell Cycle Cell Biology Cell Signaling and Neuroscience BioChemical