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Sertraline hydrochloride

Sertraline hydrochloride Structure
Sertraline hydrochloride structure
CAS No.
79559-97-0
Chemical Name:
Sertraline hydrochloride
Synonyms
SETRALINE HCL;SERTRALINE MANDELATE;Sertraline hydrochlo;Sertraline hydrochloride impurity standard;N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE;(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE;(1S,4S)-4-(3,4-Dichlorophenyl)-N-Methyl-1,2,3,4-tetrahydronaphthalen-1-aMine hydrochloride;CP-51974-1;(1s-cis)-lorid;CP-51974-1 HCl
CBNumber:
CB8157645
Molecular Formula:
C17H18Cl3N
Molecular Weight:
342.69
MDL Number:
MFCD00895772
MOL File:
79559-97-0.mol
MSDS File:
SDS
Last updated:2023-11-21 14:17:24
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Sertraline hydrochloride Properties

Melting point 246-249°C
alpha D23 +37.9° (c = 2 in methanol)
Density 1.37
Flash point 9℃
storage temp. 2-8°C
solubility DMSO: ~26 mg/mL
form solid
pka pKa (water): 9.48 ± 0.04; pKa (methanol:water, 40:60 v/v): 8.6; pKa (ethanol:water, 1:1 v/v): 8.5(at 25℃)
color white
Merck 14,8467
Stability Store in Freezer
CAS DataBase Reference 79559-97-0(CAS DataBase Reference)
FDA UNII UTI8907Y6X
NCI Drug Dictionary sertraline hydrochloride

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400
Precautionary statements  P273-P301+P312+P330
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  22-24/25-36-26-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  QJ0352070
HazardClass  IRRITANT
HS Code  29214990
NFPA 704
0
2 0

Sertraline hydrochloride price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S-021 Sertraline hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 79559-97-0 1mL $53.6 2024-03-01 Buy
Sigma-Aldrich PHR2535 Sertraline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 79559-97-0 200MG $467 2024-03-01 Buy
Sigma-Aldrich BP897 Sertraline hydrochloride impurity standard British Pharmacopoeia (BP) Reference Standard 79559-97-0 20MG $229 2024-03-01 Buy
Sigma-Aldrich BP883 Sertraline hydrochloride British Pharmacopoeia (BP) Reference Standard 79559-97-0 100MG $269 2024-03-01 Buy
Sigma-Aldrich 1612539 Sertraline hydrochloride United States Pharmacopeia (USP) Reference Standard 79559-97-0 100mg $1110 2024-03-01 Buy
Product number Packaging Price Buy
S-021 1mL $53.6 Buy
PHR2535 200MG $467 Buy
BP897 20MG $229 Buy
BP883 100MG $269 Buy
1612539 100mg $1110 Buy

Sertraline hydrochloride Chemical Properties,Uses,Production

Description

Sertraline(79559-97-0) is the hydrochloride form of sertraliine. Sertraline belongs to the selective serotonin reuptake inhibitor (SSRI) class antidepressant drug. Sertraline is indicated for the treatment of major depressive disorder in adults as well as obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder occurring in both adults and children. Its exact mechanism of action is still not fully understand. But it is indicated that this drug can selectively inhibit the reuptake of serotonin at the presynaptic membrane, increasing serotonin levels in the synapses and enhancing serotonergic neurotransmission. This effect seems to be related to the antidepressant effect of sertraliine.

References

https://en.wikipedia.org/wiki/Sertraline
https://www.drugbank.ca/drugs/DB01104

Description

Sertraline is a selective serotonin reuptake inhibitor (SSRI). It inhibits monoamine uptake by the serotonin transporter (SERT) with an IC50 value of 70 nM. It is selective for SERT over the norepinephrine and dopamine transporters (IC50s = 520 and 720 nM, respectively). Sertraline (3.2-56 mg/kg, s.c.) reduces immobility in the forced swim test in mice. Sertraline (5 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide. Formulations containing sertraline have been used in the treatment of depression, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and various anxiety disorders.

Description

Sertraline hydrochloride is a selective serotonin reuptake inhibitor, similar mechanistically to fluoxetine, introduced initially for the maintenance and long-term treatment of depression. It is reportedly non-sedating and compared to fluoxetine has a shorter duration of action and lack of CNS activating effects such as nervousness and anxiety. Sertraline hydrochloride is currently undergoing investigation for the treatment of obesity and obsessive-compulsive disorders.

Chemical Properties

White or almost white, crystalline powder.

Originator

Pfizer (USA)

Uses

A selective ST inhibitor

Uses

antibacterial

Uses

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.

Uses

A selective serotonin reuptake inhibitor. Used as an antidepressant

Definition

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive diso der, panic disorder and post-traumatic stress disorder.

Manufacturing Process

Manufacturing process for Sertraline hydrochloride includes these steps as follows: Preparation of hot ethyl acetate-pentane, Preparation of an analytical sample of 3-ethoxycarbonyl-4-(3,4- dichlorophenyl)-4-phenylbut-3-enoic acid; Preparation of 4-(3,4- dichlorophenyl)-4-phenylbut-3-enoic acid; Preparation of an analytical sample of the 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid, 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)- naphthalenone; Preparation of a white precipitate, containing about 70% cis-racemate and 30% tras-racemate of N-methyl-4-(3,4- dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; Preparation of cis-(1S)(1R)-N-methyl-4-(3,4- dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; Preparation of cis-(1S)-N-methyl-4- (3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine mandelate. The mandelate salt were suspended in ethyl acetate (about 2 L). The ethyl acetate suspension was treated with 10% aqueous NaOH solution, thereby converting the amine to the free base. The resulting ethyl acetate solution was then dried, diluted with ether (2 L) and then treated with excess gaseous hydrogen chloride to give a gelatinous suspension which crystallized overnight. The crystalline HCl salt product was separated by filtration, washed with ether and air dried. The cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride 25.96 g, 39% yield, with melting point 243°-245°C.

brand name

Zoloft (Pfizer);Lustral.

Therapeutic Function

Antidepressant

General Description

Sertraline, marketed as the brand drug Zoloft?, is an SSRI antidepressant used in the treatment of major depression as well as obsessive-compulsive, panic, and social anxiety disorders. This Certified Snap-N-Spike? Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis.

Biological Activity

Potent, orally active selective serotonin re-uptake inhibitor (SSRI) used clinically to treat depression.

Biochem/physiol Actions

Selective serotonin reuptake inhibitor, antidepressant.

storage

Desiccate at RT

Sertraline hydrochloride synthesis

267884-85-5
79559-97-0
Synthesis of Sertraline hydrochloride from Carbamic acid, N-[(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]-N-methyl-, 1,1-dimethylethyl ester

Sertraline hydrochloride Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide Methylamine 3,4-Dichlorobenzophenone Sertraline Aluminum chloride
Thionyl chloride 3,4-Dichlorobenzoyl chloride Diethyl succinate Mandelic acid Titanium tetrachloride
Hydrogen Hydrogen bromide Sodium chloride

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Preparation Products

Sertraline hydrochloride Suppliers

Global( 459)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.
+86-28-+86-28-87843998-6060-6060 +8618631098571 lijiaqi@aupone.com China 43 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 616 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691 yklbiotech@163.com CHINA 296 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293 sales@sdzschem.com China 2931 58
Supplier Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
career henan chemical co 		58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58

Related articles

View Lastest Price from Sertraline hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sertraline hydrochloride pictures 2024-03-08 Sertraline hydrochloride
79559-97-0
 US $10.00 / kg 1kg 99% 1000kg Nantong Guangyuan Chemicl Co,Ltd
Sertraline hydrochloride pictures 2023-11-27 Sertraline hydrochloride
79559-97-0
 US $610.00 / kg 0.1kg 99% min 20 tons Wuhan Senwayer Century Chemical Co.,Ltd
sertraline hydrochloride pictures 2023-10-12 sertraline hydrochloride
79559-97-0
 US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.

Sertraline hydrochloride Spectrum

Sertraline hydrochloride(79559-97-0)1HNMR

79559-97-0(Sertraline hydrochloride)Related Search:

Methyl acetate Methyl acrylate Kresoxim-methyl Topotecan hydrochloride Triethylamine hydrochloride
Dichloromethylphenylsilane 1-Naphthylamine Methylparaben Paraquat dichloride Pyridine hydrochloride
Methoxyammonium chloride Dichlorodiphenylsilane Methanol Acetonitrile Basic Violet 1
D-Glucosamine hydrochloride SERTRALINE HYDROCHLORIDE, 99.0+% (1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride

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(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE HYDROCHLORIDE (1S,4S)-1-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-(METHYLAMINO)NAPHTHALENE HYDROCHLORIDE SERTRALINE HCL FORM I SERTRALINE HCL FORM II SERTRALINE HYDROCHLORIDE Rac-cis-Sertraline-13C-d3 HCl 1-NaphthalenaMine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-Methyl-, hydrochloride (1:1),(1S,4S)- CP-51974-1 HCl Sertraline hydrochloride solution (1s-cis)-lorid 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenaminhydroch Sertralinumhydrochloride 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride, (1S,4S)- Sertaline hydrochloride (1S，4S)-4-(3，4-Dichlorophenyl)-1，2，3，4-tetrahydro-N-methyl-1-naphthylamine hydrochloride CP-51974-1 Lustral：Zoloft Sertraline hydrochloride,(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride Sertraline Hydrochloride (100 mg) (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride Sertraline hydrochloride, 98%, an antidepressant of the selective serotonin reuptake inhibitor (SSRI) (1S,4S)-4-(3,4-Dichlorophenyl)-1-(methylamino)-1,2,3,4-tetrahydronaphthalene Hydrochloride [4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]methylamine hydrochloride Sertraline Hydrochloride D3 SertralineHydrochloride> Sertraline hydrochloride CRS (+)-(1S,4S)-Sertraline hydrochloride Sertraline hydrochloride USP/EP/BP Sertraline Hydrochloride (1.0 mg/mL in Methanol) Hydrochloride Salt of Sertraline (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine Sertraline Hydrochloride Powder CAS 79559-97-0 Sertraline HCl Sertraline for peak identification (Y0000866) Sertraline for system suitability(Y0000867) Sertraline hydrochloride (Y0000828)Q: What is Sertraline hydrochloride (Y0000828) Q: What is the CAS Number of Sertraline hydrochloride (Y0000828) Q: What are the applications of Sertraline hydrochloride (Y0000828) CAS 79559-97-0 Sertraline hydrochloride Sertraline Hydrochloride (1612539) (1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE SERTRALINE MANDELATE SETRALINE HCL N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE Sertraline hydrochlo (1S,4S)-4-(3,4-Dichlorophenyl)-N-Methyl-1,2,3,4-tetrahydronaphthalen-1-aMine hydrochloride Sertraline hydrochloride impurity standard 13C6]-Sertraline HCI Sertraline salt 79559-97-0 79559-07-0 C17H17Cl2NHCl C17H17Cl2NClH C17H17NCl2HCl C1717Cl2NHCl C18H18Cl2N KETEK Active Pharmaceutical Ingredients Pharmaceutical Intermediates APIs Inhibitors