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Ranolazine dihydrochloride

Ranolazine dihydrochloride Structure
Ranolazine dihydrochloride structure
CAS No.
95635-56-6
Chemical Name:
Ranolazine dihydrochloride
Synonyms
RS 43285;RS 43285-193;RANOLAZINE HCL;Ranolazine2Hcl;Ranolazine DiHCI;azine dihydrochL;RANOLAZINE DI HCL;Ranolazine and salt;Ranolazine dihydroch;(±)-Ranolazine-d8 2HCl
CBNumber:
CB8195173
Molecular Formula:
C24H35Cl2N3O4
Molecular Weight:
500.46
MDL Number:
MFCD03788770
MOL File:
95635-56-6.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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Ranolazine dihydrochloride Properties

Melting point 222-229.5 °C(lit.)
storage temp. Desiccate at RT
solubility H2O: 10 mg/mL, soluble
form solid
color off-white
Merck 14,8111
Stability Hygroscopic
CAS DataBase Reference 95635-56-6(CAS DataBase Reference)
FDA UNII F71253DJUN

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  22-24/25
WGK Germany  3
RTECS  TK7845370
HS Code  29335990
NFPA 704
0
2 0

Ranolazine dihydrochloride price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R6152 Ranolazine dihydrochloride ≥98% (HPLC), powder 95635-56-6 100mg $256 2024-03-01 Buy
Sigma-Aldrich R6152 Ranolazine dihydrochloride ≥98% (HPLC), powder 95635-56-6 500mg $918 2024-03-01 Buy
TCI Chemical R0112 Ranolazine Dihydrochloride >98.0%(HPLC)(T) 95635-56-6 1g $194 2024-03-01 Buy
TCI Chemical R0112 Ranolazine Dihydrochloride >98.0%(HPLC)(T) 95635-56-6 5g $581 2024-03-01 Buy
Cayman Chemical 15604 Ranolazine (hydrochloride) ≥98% 95635-56-6 50mg $81 2024-03-01 Buy
Product number Packaging Price Buy
R6152 100mg $256 Buy
R6152 500mg $918 Buy
R0112 1g $194 Buy
R0112 5g $581 Buy
15604 50mg $81 Buy

Ranolazine dihydrochloride Chemical Properties,Uses,Production

Description

Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .

Chemical Properties

White Crystalline Powder

Uses

treatment of angina and congestive heart failure

Uses

Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.

Biological Activity

Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.

Biochem/physiol Actions

Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.

storage

Desiccate at RT

Ranolazine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Ranolazine dihydrochloride Suppliers

Global( 248)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hebei Jimi Trading Co., Ltd. 		+86 319 5273535 bestoneforyou@sina.com CHINA 288 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-519-519-85557386 marketing1@neostarunited.com China 8349 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17367 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Hebei Jimi Trading Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from Ranolazine dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ranolazine Dihydrochloride pictures 2021-11-20 Ranolazine Dihydrochloride
95635-56-6
 US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
Ranolazine dihydrochloride pictures 2021-07-02 Ranolazine dihydrochloride
95635-56-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Ranolazine dihydrochloride pictures 2019-07-06 Ranolazine dihydrochloride
95635-56-6
 US $100.00 / KG 1KG 99% Customized Career Henan Chemical Co

Ranolazine dihydrochloride Spectrum

Ranolazine dihydrochloride(95635-56-6)MS

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(+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride (+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE RANOLAZINE DIHYDROCHLORIDE RANOLAZINE HCL Ranolazine DiHCI Ranolazine and salt N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide di (±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide RANOLAZINE DI HCL Ranolazine2Hcl Ranolazine Dihydrocloride N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide Dihydrochloride RS 43285 RS 43285-193 (±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2μ,6μ-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide dihydrochloride 1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride(1:2) Ranolazine dihydrochloride,(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2′,6′-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinea Ranolazine dihydroch (+/-)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-diMethylphenyl)aMinocarbonylMethyl]piperazine (±)-Ranolazine-d8 2HCl N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide dihyd Ranolazine dihydrochloride N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl]acetamide dihydrochloride Ranolazine Dihydrochloride > azine dihydrochL Ranolazine dihydrochloride USP/EP/BP Ranolazine 2HCl (RS-43285 Ranolazine dihydrochlorideQ: What is Ranolazine dihydrochloride Q: What is the CAS Number of Ranolazine dihydrochloride Q: What is the storage condition of Ranolazine dihydrochloride Q: What are the applications of Ranolazine dihydrochloride Ranolazine dihydrochloride, 98%, an anti-ischemic agent Ranolazine (hydrochoride) 95635-56-6 95635-66-6 95635-55-6 C24H33N3O42HCl C24H35Cl2N3O4 C24H33N3O42ClH Active Pharmaceutical Ingredients Cardiovascular APIs Ranolazine Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Aromatics Compounds