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Sodium dihydrogen phosphate dihydrate

CAS No.
13472-35-0
Chemical Name:
Sodium dihydrogen phosphate dihydrate
Synonyms
Sodium dihydrogen orthophosphate;SODIUM BIPHOSPHATE;SODIUM PHOSPHATE, MONOBASIC, DIHYDRATE;SODIUM PHOSPHATE DIHYDRATE;SAMARIUM 1,000PPM;99.0 ~ 101.0%,ACS;Sodium dihydrogen ph;Natriumdihydrogenphosphat;MONO-SODIUM ORTHOPHOSPHATE;SODIUM PHOSPHATE 1BAS 2HYD
CBNumber:
CB8203308
Molecular Formula:
NaH2PO4·2H2O
Molecular Weight:
140.01
MDL Number:
MFCD00149209
MOL File:
13472-35-0.mol
MSDS File:
SDS
Last updated:2023-09-15 18:49:53

Sodium dihydrogen phosphate dihydrate Properties

Melting point 60 °C
Density 1,915 g/cm3
storage temp. Store at +5°C to +30°C.
solubility H2O: 1 M at 20 °C, clear, colorless
form Solid
color White
PH 4.0-4.5 (25℃, 50mg/mL in H2O)
Odor Odorless
PH Range 4.2 - 4.5
Water Solubility SOLUBLE
Sensitive Hygroscopic
λmax λ: 260 nm Amax: 0.085
λ: 280 nm Amax: 0.070
Merck 14,8660
Stability Stable.
InChIKey VBJGJHBYWREJQD-UHFFFAOYSA-M
CAS DataBase Reference 13472-35-0(CAS DataBase Reference)
FDA 21 CFR 172.892
EWG's Food Scores 1
FDA UNII 5QWK665956
EPA Substance Registry System Phosphoric acid, monosodium salt (13472-35-0)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  39-26-24/25-36
WGK Germany  1
RTECS  WA1900500
TSCA  Yes
HS Code  2835 22 00
Toxicity LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg
NFPA 704
0
0 0

Sodium dihydrogen phosphate dihydrate price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1.37018 Sodium dihydrogen phosphate dihydrate EMPROVE? EXPERT, Ph. Eur., BP, JPE, USP 13472-35-0 1KG $69 2024-03-01 Buy
Sigma-Aldrich 1.37018 Sodium dihydrogen phosphate dihydrate EMPROVE? EXPERT, Ph. Eur., BP, JPE, USP 13472-35-0 5KG $132 2024-03-01 Buy
Sigma-Aldrich 1.37018 Sodium dihydrogen phosphate dihydrate EMPROVE? EXPERT Ph Eur,BP,USP,JPE 13472-35-0 12kg $435 2024-03-01 Buy
Sigma-Aldrich 1.37018 Sodium dihydrogen phosphate dihydrate EMPROVE? EXPERT Ph Eur,BP,USP,JPE 13472-35-0 25kg $556 2024-03-01 Buy
Sigma-Aldrich 1.06345 Sodium dihydrogen phosphate dihydrate EMPROVE? ESSENTIAL Ph Eur,BP,USP,JPE,E 339 13472-35-0 1kg $37 2024-03-01 Buy
Product number Packaging Price Buy
1.37018 1KG $69 Buy
1.37018 5KG $132 Buy
1.37018 12kg $435 Buy
1.37018 25kg $556 Buy
1.06345 1kg $37 Buy

Sodium dihydrogen phosphate dihydrate Chemical Properties,Uses,Production

Description

Sodium Dihydrogen Phosphate occurs as two forms: the crystal form (dihydrate) called Sodium Dihydrogen Phosphate (crystal) and anhydrous form called Sodium Dihydrogen Phosphate (anhydrous)
It is used as an acidity regulator and sequestrant in foods. It is used as a pH buffer (baking powders, fleet enema solution, electroplating baths, and acid cleaners), emulsifier, laboratory reagent, metal phosphating reagent, and textile dyeing/printing auxiliary. It is also used to treat boiled water and waste waster and to remove halogen from waste gases. Furthermore, it is used as a cattle feed supplement, as nutritional supplement in food, in dentrifice formulations, in vitreous enamel frits, for the synthesis of pharmaceuticals, and as a phosphate source for micro-organisms in effluent treatment.

References

[1] http://sydney.edu.au
[2] https://hazmap.nlm.nih.gov
[3] https://www.chemsupply.com.au

Chemical Properties

white crystalline solid

Chemical Properties

The USP 32 states that monobasic sodium phosphate contains one or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as odorless, colorless or white, slightly deliquescent crystals. The anhydrous form occurs as a white crystalline powder or granules.

Uses

Sodium dihydrogen phosphate dihydrate acts as buffering capacity reagent in molecular biology, biochemistry and chromatography. It is used in the preparation of biological buffers. It is also used in the purification of antibodies, as a laxative and, in combination with other sodium phosphates.
Sodium phosphate monobasic dihydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. Sodium phosphate dibasic is highly hygroscopic and water soluble.
Recommended chemicals for the preparation of phosphate buffers are sodium dihydrogen phosphate dihydrate,NaH2PO4.2H2O(mol. wt.156.0),disodium hydrogen phosphate dihydrate,Na2HPO4.2H2O (mol. wt.178.0), and sodium hydroxide pellets.

Uses

Sodium dihydrogen phosphate dihydrate is typically used as a phosphate buffer system component for downstream biomolecule chromatography steps or final liquid formulation.
Due to its low microbial and endotoxin limits, Sodium dihydrogen phosphate dihydrate Emprove? Expert is especially suitable for high-risk applications.

Production Methods

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

Pharmaceutical Applications

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

Biochem/physiol Actions

Sodium phosphate monobasic also referred to as sodium dihydrogen phosphate is a chemical reagent possesses high buffering capacity and is used for preparing biological buffers. It was used as a phosphate supplement for determining whether phosphate supplementation can prevent rickets in very low birth weight infants with prenatal deficiency of phosphate.

Safety

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

storage

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

Incompatibilities

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium dihydrogen phosphate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 326)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan Shifang Jinda Chemical Co.,Ltd
+8613909025083 jinda@cn-jdchem.com China 1 58
Chongqing Chuandong Chemical (Group) Co. Ltd.
+86-13637972665 +86-13637972665 wxc@cd1958.com China 81 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Jiangsu Kolod Food Ingredients Co.,Ltd.
+86-518-85110578 +8618805133257 sales3257@jskolod.com China 132 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

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View Lastest Price from Sodium dihydrogen phosphate dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium dihydrogen phosphate dihydrate pictures 2024-03-19 Sodium dihydrogen phosphate dihydrate
13472-35-0
US $1000.00-850.00 / kilograms 1kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
MONOSODIUM PHOSPHATE DIHYDRATE   pictures 2023-10-25 MONOSODIUM PHOSPHATE DIHYDRATE
13472-35-0
US $0.00 / kg 25000kg 98%MIN 100000 Chongqing Chuandong Chemical (Group) Co. Ltd.
Sodium dihydrogen phosphate dihydrate pictures 2023-09-15 Sodium dihydrogen phosphate dihydrate
13472-35-0
US $12.50 / KG 1KG 99% 15MT Wuhan Han Sheng New Material Technology Co.,Ltd

Sodium dihydrogen phosphate dihydrate Spectrum

monosodiumdihydrogenphosphatedihydrate Phosphoricacid,monosodiumsalt,dihydrate Phosphoricacidmonosodiumsalt,dihydrate Sodiumdihydrogenphosphate,di SodiumDihydrogenPhosphateDihydrateBp SodiumDihydrogenPhosphateDihydrateUsp MonosodiumPhosphateFoodGradeHydrous SodiumDihydrogenPhosphateDihydrateIp SodiumPhosphateMonobasicDihydrateFcc SodiumDihydrogenPhosphateDihydrateAr SodiumDihydrogenPhosphateDihydrateIp/Bp MonosodiumPhosphateTechGradeHydrous SODIUM PHOSPHATE MONOBASIC 2 H2O (NaH2PO4) Sodium phosphate, monobasic dihydrate, for analysis, 99+% Natrii dihydrogenophosphas dihydricus, Sodium dihydrogen phosphate dihydrate Natriumdihydrogenphosphat Sodium phosphate, monobasic dihydrate, 99+%, for analysis Sodium phosphate, monobasic dihydrate, for analysis Monobasic sodium phosphate·dihydrate EMPROVE(R) SodiuM Dihydrogen Phosphate, Dihydrate, USP, BP, Ph Eur SodiuM phosphate, Monobasic dihydrate, for analysis, 99+% 1KG Sodium dihydrogen ph SodiuM phosphate, Monobasic dihydrate, 98%, extra pure SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE P. SodiuM phosphate, Monobasic dihydrate, >=99% SODIUM DIHYDROGEN PHOSPHATE-2-HYDRA-TE E XTRA PURE, DAB, PH. EUR., B. P.,U.S.P., SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE, F OR MOL. BIOL. SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE, C RYSTALLIZED Sdoium phsophate monobasic dihydrate Sodium dihydrogen phosphate dihydrate USP28 SAMARIUM 1,000PPM SLANETZ + BARTLEYAR WITHOUT TTC 55MM Sodium phosphate monobasic dihydrate Vetec(TM) reagent grade, >=99% NICOTINIC ACID LINEARITY SET (RSPEC1027) Sodium dihydrogen phosphate dihydrate suitable for the biopharmaceutical production EMPROVE bio Ph Eur,BP,USP,JPE Sodium Phosphate Monobasic Dihydrate, Meets analytical specification of Ph. Eur., BP, USP, FCC Sodium Phosphate, Monobasic, Dihydrate, EMSURE?, For Analysis SODIUM BIPHOSPHATE DIHYDRATE SODIUM DIHYDROGEN ORTHOPHOSPHATE 2H2O SODIUM DIHYDROGEN ORTHOPHOSPHATE DIHYDRATE SODIUM DIHYDROGEN ORTHOPHOSPHATE MONOBASIC, DIHYDRATE SODIUM DI-HYDROGEN PHOSPATE 2H2O SODIUM DIHYDROGEN PHOSPHATE 2H2O SODIUM DIHYDROGEN PHOSPHATE-2-HYDRATE SODIUM DIHYDROGEN PHOSPHATE, DIBASIC, DIHYDRATE SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE SODIUM PHOSPHATE MONOBASIC 2H2O NATRII DIHYDROGENOPHOSPHAS DIHYDRICUS MONO-SODIUM PHOSPHATE DIHYDRATE MONO-SODIUM ORTHOPHOSPHATE MONO-SODIUM ORTHOPHOSPHATE DIHYDRATE Sodium phosphate monobasic dihydrate,AR,≥99% Sodium phosphate monobasic dihydrate 、Acid sodium phosphate Sodium dihydrogen phospate dihydrate Phosphoric acid (sodium hydrate),≥99.0% Sodium dihydrogen orthophosphate, dihydrate, for molecular biology, 99.5% Sodium di-hydrogen o-phosphate dihydrate BP 500GM Sodium di-hydrogen o-phosphate dihydrate BP 25KG