Rosmanol
- CAS No.
- 80225-53-2
- Chemical Name:
- Rosmanol
- Synonyms
- Rosmano;20-Deoxocarnosol;rat tail oxalic acid;rosemary antioxidant;Rosmanol,Inhibitor,inhibit;Keywords honeysuckle extract;6β,7α,11,12-Tetrahydroxyabieta-8,11,13-trien-20-oic acid 20,6-lactone;(4bR,8aS,9R,10S)-3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one;(4aR,10aα)-1,3,4,9,10,10a-Hexahydro-5,6,9α-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10β,4aβ-(epoxymethano)phenanthren-12-one
- CBNumber:
- CB82131157
- Molecular Formula:
- C20H26O5
- Molecular Weight:
- 346.42
- MDL Number:
- MFCD12031636
- MOL File:
- 80225-53-2.mol
- MSDS File:
- SDS
| Melting point | 212-213 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 574.2±50.0 °C(Predicted) |
| Density | 1.33 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | A solid |
| pka | 9.07±0.60(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | F25TV383OC |
Rosmanol price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | R2999-90 | Rosmarinic Acid | 80225-53-2 | 50mg | $276 | 2021-12-16 | Buy |
| Usbiological | 300896 | Rosmarinic acid | 80225-53-2 | 20mg | $277 | 2021-12-16 | Buy |
| Usbiological | 020735 | Rosmarinic Acid | 80225-53-2 | 5g | $496 | 2021-12-16 | Buy |
| Usbiological | 256499 | Rosmarinic acid | 80225-53-2 | 50mg | $403 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR167087 | Rosmanol | 80225-53-2 | 1mg | $60 | 2021-12-16 | Buy |
Rosmanol Chemical Properties,Uses,Production
Anticancer Research
This is a polyphenol and an ester of caffeic acid and 3,4-dihydroxyphylllique acid.This is commonly found in Boraginaceae species and Nepettoideae, a Lamiaceaesubfamily. It plays an important role in anti-inflammatory, antitumor, andantiproliferation activities. It shows a dose-dependent inhibition of invasion,migration, and adhesion of LS-174-T human colon carcinoma cells. It inhibits thebone metastasis from breast cancer via NF-κB and its downward IL-8 pathway(Wang et al. 2012). It reduces ERK and COX-2 phosphorylation in colon carcinoma.It reduces the activity of DNA methyltransferase and interferes with RANKL/RANK/OPG networks in breast cancer cells. It targets NF-kB pathway in U938cells and PKA/CREB/MITF pathways in melanoma cells (Singh et al. 2016b). InU938 human leukemic cells, it sensitizes TNF-α-induced apoptosis by affectingNF-kB and ROS and inhibits the activation of NF-kB by inhibiting IκBαphosphorylation and degradation. It also reduces the levels of promoter activity ofCOX-2 protein induced by TPA in HT-29 colon cancer cells and antagonizes TPAstimulating effects on COX-2 expression (Petersen and Simmonds 2003).
Cytotoxicity
IC50 (μg/mL): 1.71 (A2780), 6.96(SW1573), 10.13 (WiDr), 10.13 (T-47D),1.46 (HBL-100) (Guerrero et al. 2006;Zhang et al. 2017)
Rosmanol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
