Unii-4U07F515lg
- CAS No.
- 496775-62-3
- Chemical Name:
- Unii-4U07F515lg
- Synonyms
- Eltrombopag olamine;Eltrombopag Diolamine;EltroMbopag OlaMine API;Revolade;Sb 497115gr;Unii-4U07F515;ELTROMBOPAG OL;Unii-4U07F515lg;Eltrombopag API;Promacta Olamine
- CBNumber:
- CB82495099
- Molecular Formula:
- C27H29N5O5
- Molecular Weight:
- 503.56
- MDL Number:
- MFCD22380664
- MOL File:
- 496775-62-3.mol
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
|---|---|
| solubility |
DMSO:56.33(Max Conc. mg/mL);99.76(Max Conc. mM) DMF:1.0(Max Conc. mg/mL);1.77(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.44(Max Conc. mM) Ethanol:0.1(Max Conc. mg/mL);0.18(Max Conc. mM) |
| form | Powder |
| Stability | Hygroscopic |
| InChIKey | LQQUHOUXABUDJA-OUFJFOJPSA-N |
| SMILES | C(N)CO.O=C1/C(/C(C)=NN1C1C=CC(C)=C(C)C=1)=N\NC1C=CC=C(C2C=CC=C(C(=O)O)C=2)C=1O |
| NCI Dictionary of Cancer Terms | eltrombopag olamine |
| FDA UNII | 4U07F515LG |
| NCI Drug Dictionary | eltrombopag olamine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H412 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P273-P501 |
Unii-4U07F515lg price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E508100 | EltrombopagOlamine | 496775-62-3 | 5mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD157443 | 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid compd.with 2-aminoethanol | 496775-62-3 | 500mg | $65 | 2021-12-16 | Buy |
| AK Scientific | 3608AH | Eltrombopagolamine | 496775-62-3 | 10mg | $75 | 2021-12-16 | Buy |
| ApexBio Technology | A3387 | EltrombopagOlamine | 496775-62-3 | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD157443 | 3'-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid compd.with 2-aminoethanol | 496775-62-3 | 1g | $100 | 2021-12-16 | Buy |
Unii-4U07F515lg Chemical Properties,Uses,Production
Description
Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough.Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Uses
Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura.
Clinical Use
Eltrombopag olamine, a thrombopoietin receptor (TpoR) agonist, was approved in late 2008 for the once-daily, oral short-term and long-term treatment of adult patients with previously treated chronic idiopathic thrombocytopenic purpura (ITP). It is the first small-molecule TpoR agonist and was launched in the U.S. for this indication in 2009 by GlaxoSmithKline (GSK). Because eltrombopag is a small molecule, the drug is administered orally and has a reduced potential for causing an immune system reaction versus alternative protein-based therapies. In 2010, eltrombopag was approved in Europe for the long-term treatment of adult patients with previously treated chronic ITP.
Synthesis
The synthesis began with the nitration of 2-bromophenol (39) with sodium nitrate and sulfuric acid in water at 10??C to give 2-bromo-6-nitrophenol (40) in 25% yield, which was methylated using methyl iodide and potassium carbonate in refluxing acetone providing 2-bromo- 6-nitroanisole (41) in 76% yield (the Scheme).40 Suzuki coupling of compound 41 with 3-carboxyphenyl boronic acid with Pd(PPh3)4 and 2 M sodium carbonate in refluxing dioxane gave 20-methoxy- 30-nitrobiphenyl-3-carboxylic acid (42) in 47% yield as a tan powder. Demethylation using 48% HBr (aq) in refluxing acetic acid resulted in a 79% yield of 20-hydroxy-30-nitrobiphenyl-3-carboxylic acid (43). The nitro group of compound 43 was reduced via catalytic hydrogenation at 50 psi at room temperature over Pd/C in mixed ethanol/3 M aq NaOH solution to give 30-amino-20-hydroxybiphenyl- 3-carboxylic acid (44) in quantitative yield. The intermediate 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1Hpyrazol- 5-one (47) was prepared by condensing of 3,4-dimethylphenyl- hydrazine 45 with ethyl acetoacetate 46 with sodium acetate in refluxing acetic acid in 76% yield. Treatment of (44) with sodium nitrite in 1 M HCl at 5??C, followed by condensation with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one (47) at a constant pH of 7¨C8 via the addition of sodium bicarbonate and ethanol afforded eltrombopag in 32% yield. Finally, eltrombopag was treated with hydroxyl ethylamine to give eltrombopag olamine (VIII).
Unii-4U07F515lg Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Mesochem Technology Co.,Ltd | +8613651027935 | rachel@mesochem.com | China | 191 | 58 |
| Jewim Pharmaceutical (Shandong) Co., Ltd. | +86-15552509998 +86-15621883869 | liutf@jewim.com.cn | China | 251 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
View Lastest Price from Unii-4U07F515lg manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-02 | Unii-4U07F515lg
496775-62-3
|
US $85.00-850.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2023-11-27 | Eltrombopag Olamine
496775-62-3
|
US $0.00 / KG | 1KG | 99% | 20 TONS | Wuhan Senwayer Century Chemical Co.,Ltd | |
 |
2023-07-31 | Eltrombopag Olamine
496775-62-3
|
US $10.00 / kg | 20kg | 99.95% | 500tons | Hebei Linwo New Material Technology Co., LTD |
-
- Unii-4U07F515lg
496775-62-3
- US $85.00-850.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Eltrombopag Olamine
496775-62-3
- US $0.00 / KG
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
-
- Eltrombopag Olamine
496775-62-3
- US $10.00 / kg
- 99.95%
- Hebei Linwo New Material Technology Co., LTD
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