Minodronic Acid
- CAS No.
- 155648-60-5
- Chemical Name:
- Minodronic Acid
- Synonyms
- Minodronic acid API;Minodronate Monohydrate;Minodronic Acid hydrate;MinodronateMonohydrate>Minodronic Acid Monohydrate;Minophosphonic acid monohydrate;CAS No.155648-60-5 Minodronic Acid;1-Hydroxy-2-[imidazo[1,2-a]pyridin-3-yl]ethylidene-1,1-diphosphonic Acid;P,P'-(1-Hydroxy-2-imidazo[1,2-a]pyridin-3-ylethylidene)bisphosphonic acid hydrate;(1-Hydroxy-2-(iMidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid hydrate
- CBNumber:
- CB82521286
- Molecular Formula:
- C9H14N2O8P2
- Molecular Weight:
- 340.163582
- MDL Number:
- MFCD00890772
- MOL File:
- 155648-60-5.mol
| storage temp. | 2-8°C |
|---|---|
| Water Solubility | Insoluble in water |
| form | powder to crystal |
| color | White to Light yellow to Light red |
| FDA UNII | 457X74V7ND |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H361 |
| Precautionary statements | P201-P202-P264-P270-P280-P301+P310+P330-P308+P313-P405-P501 |
| RIDADR | 2811 |
| RTECS | SZ8562470 |
| HS Code | 2933.99.8290 |
| HazardClass | 6.1 |
| PackingGroup | III |
Minodronic Acid price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2360 | Minodronate Monohydrate >98.0%(HPLC) | 155648-60-5 | 25mg | $207 | 2024-03-01 | Buy |
| AK Scientific | Y0229 | Minodronicacidmonohydrate | 155648-60-5 | 25mg | $236 | 2021-12-16 | Buy |
| Chem-Impex | 38053 | Minodronatemonohydrate,98%(HPLC) 98%(HPLC) | 155648-60-5 | 25MG | $275.52 | 2021-12-16 | Buy |
| AvaChem | 2663H | Minodronic Acid Hydrate | 155648-60-5 | 1g | $390 | 2021-12-16 | Buy |
| DC Chemicals | DC8796 | Minodronicacidmonohydrate >98% | 155648-60-5 | 250mg | $400 | 2021-12-16 | Buy |
Minodronic Acid Chemical Properties,Uses,Production
Clinical Use
The bone resorption inhibitor minodronic acid hydrate was approved and introduced last year in Japan, bringing the total number of bis-phosphonates marketed for this indication to seven. There are an estimated 10 million current and potential osteoporosis sufferers in Japan, a number that is expected to continue growing due to the country’s aging population. Minodronic acid is the first drug to show a significant effect in preventing bone fractures as compared to placebo in a Japanese patient population. Minodronic acid was co-developed by Astellas and Ono, who are marketing the drug as Bonoteo and Recalbon, respectively.
Synthesis
Several syntheses of minodronic acid have been reported,a scalable preparation is described in the scheme. Commercially available acid chloride 71 was first reduced with lithium tritertbutoxy aluminum hydride to the aldehyde 72 at 80??C in 61% yield. Next, reaction of aldehyde 72 with TMSCl and triethylamine generated the corresponding silyl enol ether, which was then treated with bromine to give a-bromoaldehyde 73 in 62% yield. Condensation with 2-amino pyridine furnished imidazopyridine 74, which was hydrolyzed with HCl to acid 75 in 58% yield. Reaction with H3PO3 at 120??C to provide minodronic acid hydrate (XII) in 53% yield.
Minodronic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3708 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Hebei Bonster Technology Co.,Limited | +8613315996897 | bsterltd.wendy@gmail.com | China | 796 | 58 |
View Lastest Price from Minodronic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-09-29 | Minodronic Acid
155648-60-5
|
US $0.00 / g | 10g | 99.0% | 20kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-07-13 | Minodronic Acid
155648-60-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Minodronic Acid
155648-60-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Minodronic Acid
155648-60-5
- US $0.00 / g
- 99.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Minodronic Acid
155648-60-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Minodronic Acid
155648-60-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd