ChemicalBook >> CAS DataBase List >>4-Chloro-3-(trifluoromethyl)phenyl isocyanate
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
- CAS No.
- 327-78-6
- Chemical Name:
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
- Synonyms
- 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene;Sorafenib INT1;Sorafenib intermediate 3;4-chloro-a,a,a-trifluoro-M-tolyl ester;4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate;4-CHLORO-3-TRIFLUROMETHYL)PHENYL ISOCYANATE;3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE;4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE;4-Chloro-3-(trifluoromethy) phenyl isocyanate;4-Chloro-3-(trifluoroMethoxy)phenyl Isocyanate
- CBNumber:
- CB8262374
- Molecular Formula:
- C8H3ClF3NO
- Molecular Weight:
- 221.56
- MDL Number:
- MFCD00013874
- MOL File:
- 327-78-6.mol
- MSDS File:
- SDS
Last updated:2024-01-18 17:03:10
| Melting point | 40-42 °C(lit.) |
|---|---|
| Boiling point | 86-90 °C14 mm Hg(lit.) |
| Density | 1.4720 (estimate) |
| vapor pressure | 91Pa at 20℃ |
| Flash point | 211 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Chloroform, Methanol |
| form | Low Melting Solid, Powder or Chunks |
| color | White to yellow |
| Sensitive | Moisture Sensitive |
| BRN | 522032 |
| InChI | InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H |
| InChIKey | AHFPRSSHNSGRCU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=CC=C(N=C=O)C=C1C(F)(F)F |
| CAS DataBase Reference | 327-78-6(CAS DataBase Reference) |
| FDA UNII | 6TE36JKP7L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H315-H317-H318-H334-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37-36/37/38-42-20/22 | |||||||||
| Safety Statements | 7-26-27-37/39-36/37/39-45-23 | |||||||||
| RIDADR | UN 2206 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful/Moisture Sensitive | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29291090 | |||||||||
| NFPA 704 |
|
4-Chloro-3-(trifluoromethyl)phenyl isocyanate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 374881 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 98% | 327-78-6 | 5g | $16.86 | 2024-03-01 | Buy |
| TCI Chemical | C2778 | 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) | 327-78-6 | 5g | $78 | 2024-03-01 | Buy |
| TCI Chemical | C2778 | 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) | 327-78-6 | 25g | $248 | 2024-03-01 | Buy |
| Alfa Aesar | L12016 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate, 97% | 327-78-6 | 5g | $80.65 | 2024-03-01 | Buy |
| TRC | C421940 | 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate | 327-78-6 | 5g | $65 | 2021-12-16 | Buy |
4-Chloro-3-(trifluoromethyl)phenyl isocyanate Chemical Properties,Uses,Production
Chemical Properties
White solid or melt
Uses
4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of:
- N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea
- [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea]
- trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
Uses
4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of: N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea] trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
General Description
4-Chloro-3-(trifluoromethyl)phenyl isocyanate participates in an efficient methodology for the synthesis of 5-methyl-3-aryl-2-thiooxazolidin-4-ones.
Flammability and Explosibility
Non flammable
Synthesis of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate from Triphosgene and 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine
4-Chloro-3-(trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 455)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 | info@senovatech.com | China | 349 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
View Lastest Price from 4-Chloro-3-(trifluoromethyl)phenyl isocyanate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-10 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
|
US $0.00 / kg | 1kg | 98% | 500kg | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2024-01-18 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
|
US $6.00-0.60 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-12-26 | 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
- US $6.00-0.60 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
327-78-6(4-Chloro-3-(trifluoromethyl)phenyl isocyanate)Related Search:
Propyl isocyanate
4-Chlorobenzotrifluoride
Benzotrifluoride
4-(Chloromethyl)benzoic acid
3-Fluorobenzotrifluoride
Vinylbenzyl chloride
Phenyl butyrate
Chlorosulfonyl isocyanate
Diphenyl chlorophosphate
Phenyl isothiocyanate
1of4
4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE
4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE 98%
4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate
4-Chloro-3-(trifluoromethyl)phenyl isocyanate,98%
4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 98% 5GR
Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)-
4-chloro-a,a,a-trifluoro-M-tolyl ester
4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 97.5%
4-Chloro-3-(trifluoroMethoxy)phenyl Isocyanate
Three fluorine chlorine - 4-3 - Methyl phenyl isocyanate
Sorafenib INT1
Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester
4-CHLORO-3-TRIFLUROMETHYL)PHENYL ISOCYANATE
4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)
4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >
4-Chloro-3-(trifluoromethy) phenyl isocyanate
1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene
Phenyl 4- chloro -3- trifluoromethyl isocyanate
Sorafenib intermediate 3
327-78-6
372-78-6
ClC6H3CF3NCO
ARYL ISOCYANATE
Building Blocks
Organic Building Blocks
Nitrogen Compounds
Isocyanates
Phenyl isocyanate&Phenyl isothiocyanate
Isocyanates
Nitrogen Compounds
Organic Building Blocks