ACY-1215
- CAS No.
- 1316214-52-4
- Chemical Name:
- ACY-1215
- Synonyms
- ACY 63;CS-583;ACY-1215;Propane-1;Ricolinostat;Rocilinostat;ACY-1215/ACY1215;Rocilinostat, >=99%;3-tricarboxylic acid;β-Carboxyglutaric acid
- CBNumber:
- CB82627292
- Molecular Formula:
- C24H27N5O3
- Molecular Weight:
- 433.5
- MDL Number:
- MFCD22666356
- MOL File:
- 1316214-52-4.mol
- MSDS File:
- SDS
| Melting point | 189 - 191°C |
|---|---|
| Density | 1.239±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.47±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | WKT909C62B |
| NCI Drug Dictionary | ricolinostat |
ACY-1215 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21531 | ACY-1215 ≥98% | 1316214-52-4 | 25mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 21531 | ACY-1215 ≥98% | 1316214-52-4 | 50mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 21531 | ACY-1215 ≥98% | 1316214-52-4 | 100mg | $228 | 2024-03-01 | Buy |
| Cayman Chemical | 21531 | ACY-1215 ≥98% | 1316214-52-4 | 250mg | $494 | 2024-03-01 | Buy |
| TRC | D486990 | 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide | 1316214-52-4 | 250mg | $275 | 2021-12-16 | Buy |
ACY-1215 Chemical Properties,Uses,Production
Description
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.
Uses
This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).
Definition
ChEBI: N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide is a pyrimidinecarboxylic acid.
target
HDAC6
ACY-1215 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from ACY-1215 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | ACY-1215
1316214-52-4
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2022-10-14 | ACY-1215
1316214-52-4
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2022-04-19 | ACY-1215
1316214-52-4
|
US $0.00-0.00 / g | 1g | 98% | 10 grams | Shenzhen Shengda Pharma Limited |