ChemicalBook >> CAS DataBase List >>tert-Butyl 1-piperazinecarboxylate
tert-Butyl 1-piperazinecarboxylate
- CAS No.
- 57260-71-6
- Chemical Name:
- tert-Butyl 1-piperazinecarboxylate
- Synonyms
- BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene;BUTTPARK 52\11-35
- CBNumber:
- CB8268275
- Molecular Formula:
- C9H18N2O2
- Molecular Weight:
- 186.25
- MDL Number:
- MFCD00075265
- MOL File:
- 57260-71-6.mol
- MSDS File:
- SDS
Last updated:2024-03-22 17:12:53
| Melting point | 43-47 °C(lit.) |
|---|---|
| Boiling point | 98-100 |
| Density | 1.030±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO |
| pka | 8.45±0.10(Predicted) |
| form | Low Melting Crystalline Mass |
| color | White to light yellow |
| Water Solubility | Soluble in ethyl acetate, methanol and water. |
| Sensitive | Air Sensitive |
| BRN | 879985 |
| InChIKey | CWXPZXBSDSIRCS-UHFFFAOYSA-N |
| CAS DataBase Reference | 57260-71-6(CAS DataBase Reference) |
| FDA UNII | LBC2X3S28C |
| NIST Chemistry Reference | T-butyl 1-piperaziencarboxylate(57260-71-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3263 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-34 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335995 | |||||||||
| NFPA 704 |
|
tert-Butyl 1-piperazinecarboxylate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15502 | 1-Boc-piperazine ≥98.0% (GC) | 57260-71-6 | 5g | $111 | 2024-03-01 | Buy |
| Sigma-Aldrich | 15502 | 1-Boc-piperazine ≥98.0% (GC) | 57260-71-6 | 25g | $265 | 2024-03-01 | Buy |
| TCI Chemical | B2415 | 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) | 57260-71-6 | 5g | $71 | 2024-03-01 | Buy |
| TCI Chemical | B2415 | 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) | 57260-71-6 | 25g | $228 | 2024-03-01 | Buy |
| Alfa Aesar | L13363 | 1-Boc-piperazine, 99% | 57260-71-6 | 1g | $29.65 | 2024-03-01 | Buy |
tert-Butyl 1-piperazinecarboxylate Chemical Properties,Uses,Production
Uses
N-Boc-piperazine is a compound useful in organic synthesis.
Chemical Properties
Waxy Solid
Uses
1-Boc-piperazine may be used in:
- preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
- termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
- preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors
Uses
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.
Application
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
General Description
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.
tert-Butyl 1-piperazinecarboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE
PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER
1-(2-Methoxyethyl)piperazine
1-(CYCLOPROPYLMETHYL)PIPERAZINE
tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%
1-Boc-4-(2-formylphenyl)piperazine
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
1-(2-PYRAZINYL)-PIPERAZINE
1-(3-Chlorphenyl)piperazine
N-Boc-4-(Cyclopropylmethyl)piperazine
1of4
Global( 841)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | alice@jndxj.com | China | 309 | 58 |
| Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1269 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +8618922120635 | sales@toref-standards.com | China | 1000 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
Related articles
- Different applications of 1-tert-Butoxycarbonylpiperazine
- 1-tert-Butoxycarbonylpiperazine is an important chemical product.
- Jun 15，2022
View Lastest Price from tert-Butyl 1-piperazinecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | tert-Butyl 1-piperazinecarboxylate
57260-71-6
|
US $2.00 / kg | 1kg | 99% | 100mt | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-22 | tert-Butyl 1-piperazinecarboxylate
57260-71-6
|
US $30.00 / kg | 1kg | 98% | 3000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-04-12 | tert-Butyl 1-piperazinecarboxylate
57260-71-6
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
-
- tert-Butyl 1-piperazinecarboxylate
57260-71-6
- US $2.00 / kg
- 99%
- Jinan Finer Chemical Co., Ltd
-
- tert-Butyl 1-piperazinecarboxylate
57260-71-6
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- tert-Butyl 1-piperazinecarboxylate
57260-71-6
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
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