2-VALERYLOXYBENZOIC ACID
- CAS No.
- 64206-54-8
- Chemical Name:
- 2-VALERYLOXYBENZOIC ACID
- Synonyms
- VSA;VALERYL SALICYLATE;VALEROYL SALICYLATE;VALERYLSALICYLIC ACID;salicylicacid,valerate;2-VALERYLOXYBENZOIC ACID;WJHZBTMHUNVIKC-UHFFFAOYSA-N;2-[(1-OXOPENTYL)OXY]-BENZOIC ACID;Benzoic acid, 2-[(1-oxopentyl)oxy]-;2-Valeryloxybenzoic acid, Valerylsalicylic acid, vsa
- CBNumber:
- CB8270272
- Molecular Formula:
- C12H14O4
- Molecular Weight:
- 222.24
- MDL Number:
- MFCD00041466
- MOL File:
- 64206-54-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
2-VALERYLOXYBENZOIC ACID price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V2889 | Valeryl Salicylate ≥98% (HPLC) | 64206-54-8 | 100mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 70670 | Valeroyl Salicylate ≥99% | 64206-54-8 | 50mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 70670 | Valeroyl Salicylate ≥99% | 64206-54-8 | 100mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 70670 | Valeroyl Salicylate ≥99% | 64206-54-8 | 500mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 70670 | Valeroyl Salicylate | 64206-54-8 | 1000mg | $426 | 2024-03-01 | Buy |
2-VALERYLOXYBENZOIC ACID Chemical Properties,Uses,Production
Uses
Valeryl salicylate is a selective inhibitor of Cox-1.
Definition
ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.
Biological Activity
valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].
References
[1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.
2-VALERYLOXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-VALERYLOXYBENZOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 | 359382369@qq.com | China | 10367 | 58 |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | 1986399151@qq.com | China | 9849 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |