ChemicalBook >> CAS DataBase List >>Diphenylphosphinic Chloride
Diphenylphosphinic Chloride
- CAS No.
- 1499-21-4
- Chemical Name:
- Diphenylphosphinic Chloride
- Synonyms
- DPPC;DIPHENYLPHOSPHINIC CHLORIDE;DPP-CL;Ph2POCl;phosphinic chL;Diphenylphoshinic;CHLORODIPHIOSPHINE OXIDE;DIPHENYLPHOSHINIC CHLORIDE;Diphenylphosphinic chlorid;DIPHENYLPHOSPHINYL CHLORIDE
- CBNumber:
- CB8273899
- Molecular Formula:
- C12H10ClOP
- Molecular Weight:
- 236.63
- MDL Number:
- MFCD00002077
- MOL File:
- 1499-21-4.mol
- MSDS File:
- SDS
Last updated:2023-11-29 15:50:19
| Melting point | 20°C |
|---|---|
| Boiling point | 222 °C/16 mmHg (lit.) |
| Density | 1.24 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 79 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, methanol |
| form | Liquid |
| Specific Gravity | 1.24 |
| color | Clear colorless to yellow |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 975191 |
| CAS DataBase Reference | 1499-21-4(CAS DataBase Reference) |
| FDA UNII | 5GP30GY04V |
| NIST Chemistry Reference | Diphenylphosphinic chloride(1499-21-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C,F | |||||||||
| Risk Statements | 10-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Flammable/Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| NFPA 704 |
|
Diphenylphosphinic Chloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 230235 | Diphenylphosphinic chloride 98% | 1499-21-4 | 10g | $75.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 230235 | Diphenylphosphinic chloride 98% | 1499-21-4 | 50g | $296 | 2024-03-01 | Buy |
| TCI Chemical | C1415 | Diphenylphosphinic Chloride >98.0%(GC)(T) | 1499-21-4 | 25g | $121 | 2024-03-01 | Buy |
| Alfa Aesar | A11721 | Diphenylphosphinic chloride, 97+% | 1499-21-4 | 5g | $36.65 | 2024-03-01 | Buy |
| Alfa Aesar | A11721 | Diphenylphosphinic chloride, 97+% | 1499-21-4 | 25g | $118.65 | 2024-03-01 | Buy |
Diphenylphosphinic Chloride Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellow liquid
Uses
Diphenylphosphinic chloride (Ph2POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.
Application
Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.
Synthesis
To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.
Diphenylphosphinic Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 364)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHANGZHOU HARVECHEM LTD | +86-0519-88784888 +8613906120163 | inquiry@harvechem.com | China | 245 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
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| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3453 | 58 |
View Lastest Price from Diphenylphosphinic Chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | Diphenylphosphinic chloride, 98%
1499-21-4
|
US $20.00 / KG | 1KG | 98% | 200tons/ year | Speranza Chemical Co., Ltd. | |
 |
2023-01-31 | Diphenylphosphinyl chloride
1499-21-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-09-27 | Diphenylphosphinyl chloride
1499-21-4
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Diphenylphosphinic chloride, 98%
1499-21-4
- US $20.00 / KG
- 98%
- Speranza Chemical Co., Ltd.
-
- Diphenylphosphinyl chloride
1499-21-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Diphenylphosphinyl chloride
1499-21-4
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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Catalysis and Inorganic Chemistry
Organic Building Blocks
Phosphorus Compounds
Phosphorus Halides
Phosphorus Precursors
Reagents for Oligosaccharide Synthesis
Peptide Synthesis
Protection & Derivatization Reagents (for Synthesis)
Coupling Reactions (Peptide Synthesis)
Building Blocks
Biochemistry
Coupling Reactions (Peptide Synthesis)
Peptide Synthesis
Protection & Derivatization Reagents (for Synthesis)
Reagents for Oligosaccharide Synthesis
Synthetic Organic Chemistry
Phosphorus compounds
Pharmaceutical Intermediates
organophosphorus compound