3-IODOBENZYL-GUANIDINE HEMISULFATE
- CAS No.
- 87862-25-7
- Chemical Name:
- 3-IODOBENZYL-GUANIDINE HEMISULFATE
- Synonyms
- M-IBG;MIBG sulfate;MIBG hemisulfate;MIBG HEMISULFATE SALT;Iobenguane sulfate CRS;Iobenguane Hemisulfate;Nafamostat Impurity 14;m-iodobenzylguanidine sulfate;M-IODOBENZYLGUANIDINE 1/2H2SO4;3-IODOBENZYL-GUANIDINE HEMISULFATE
- CBNumber:
- CB8278137
- Molecular Formula:
- C16H22I2N6O4S
- Molecular Weight:
- 648.26
- MDL Number:
- MFCD00151189
- MOL File:
- 87862-25-7.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml |
| form | A crystalline solid |
| FDA UNII | S8I0922465 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| HS Code | 2909309090 |
3-IODOBENZYL-GUANIDINE HEMISULFATE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I9890 | m-Iodobenzylguanidine hemisulfate salt ≥98%(HPLCandTLC) | 87862-25-7 | 5mg | $148 | 2024-03-01 | Buy |
| Sigma-Aldrich | I9890 | m-Iodobenzylguanidine hemisulfate salt ≥98% (HPLC and TLC) | 87862-25-7 | 25MG | $301.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | I0328000 | Iobenguane sulfate European Pharmacopoeia (EP) Reference Standard | 87862-25-7 | I0328000 | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 19998 | m-Iodobenzylguanidine (hemisulfate) | 87862-25-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19998 | m-Iodobenzylguanidine (hemisulfate) | 87862-25-7 | 5mg | $93 | 2024-03-01 | Buy |
3-IODOBENZYL-GUANIDINE HEMISULFATE Chemical Properties,Uses,Production
Description
m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity. It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 μg/ml and reduces clonogenic survival of L1210 leukemia cells in a concentration-dependent manner. MIBG increases survival in N1E155 and L1210 mouse xenograft models when administered at doses of 40 and 20 mg/kg, respectively. It selectively accumulates in chromaffin tissues and tumors and formulations containing radiolabeled forms of MIBG have been used as imaging agents in the diagnosis and treatment of neuroendocrine tumors. MIBG also inhibits ADP-ribose linkage to membrane proteins in turkey erythrocyte membranes.
Chemical Properties
Colourless to off-white solid
Uses
m-Iodobenzylguanidine Hemisulfate?can be used to demethylate and oxidize membrane-associated DNA. It has also been employed to develop a cell-based high-throughput screening assay to identify anti-hepatitis C virus compounds.
Biochem/physiol Actions
Antitumor agent which inhibits ADP ribosylation.
3-IODOBENZYL-GUANIDINE HEMISULFATE Preparation Products And Raw materials
Raw materials
Preparation Products
3-IODOBENZYL-GUANIDINE HEMISULFATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3427 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4985 | 55 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 8041 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |