ChemicalBook >> CAS DataBase List >>Simeprevir sodium
Simeprevir sodium
- CAS No.
- 1241946-89-3
- Chemical Name:
- Simeprevir sodium
- Synonyms
- Olysio;Simeprevir sodium;TMC 435 sodium salt
- CBNumber:
- CB83043307
- Molecular Formula:
- C38H47N5O7S2.x(Na)
- Molecular Weight:
- 773.94
- MDL Number:
- MFCD30724946
- MOL File:
- 1241946-89-3.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:03:09
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM) |
| form | A crystalline solid |
| FDA UNII | 16U7H60184 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H334-H317-H341-H361-H370-H335-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P301+P312-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P330-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
Simeprevir sodium price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 25mg | $638 | 2024-03-01 | Buy |
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 22144 | Simeprevir (sodium salt) | 1241946-89-3 | 10mg | $278 | 2024-03-01 | Buy |
Simeprevir sodium Chemical Properties,Uses,Production
Description
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
Simeprevir sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 27)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Zhuoer Chemical Co., Ltd | 02120970332; +8613524231522 | sales@zhuoerchem.com | China | 2980 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 822 | 65 |
1241946-89-3(Simeprevir sodium)Related Search:
Simeprevir sodium
TMC 435 sodium salt
Olysio
1241946-89-3
C38H47N5O7S2xNa