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Enrofloxacin

CAS No.
93106-60-6
Chemical Name:
Enrofloxacin
Synonyms
ENROFLOXACIN HCL;Enrofloxacine;Enorfloxacin;1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinoli;Enrofloxacin CRS;Enrofloxacin Impurity 2;Enorofloxacin hydrochloride;1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;cfpq;Baytri
CBNumber:
CB8310192
Molecular Formula:
C19H22FN3O3
Molecular Weight:
359.39
MDL Number:
MFCD00792463
MOL File:
93106-60-6.mol
Last updated:2024-03-22 17:12:53

Enrofloxacin Properties

Melting point 225 °C
Boiling point 560.5±50.0 °C(Predicted)
Density 1.385±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Very Slightly, Heated)
form powder or crystals
pka 6.43±0.41(Predicted)
color Pale Yellow to Light Beige
Water Solubility Soluble in chloroform. Slightly soluble in water. Also soluble in dilute KOH
Merck 14,3592
BRN 5307824
FDA 21 CFR 556.226
CAS DataBase Reference 93106-60-6(CAS DataBase Reference)
FDA UNII 3DX3XEK1BN
EPA Substance Registry System 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- (93106-60-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H317-H334
Precautionary statements  P261-P264-P270-P280-P301+P312-P302+P352
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37-24/25
WGK Germany  3
RTECS  VB1993650
HS Code  29339900
Toxicity LD50 in male, female mice (mg/kg): >5000, 4336 orally; ~200, ~200 i.v.; in male rats, male rabbits (mg/kg): >5000, 500-800 orally (Altreuther)
NFPA 704
0
1 0

Enrofloxacin price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1513 Enrofloxacin Pharmaceutical Secondary Standard; Certified Reference Material 93106-60-6 500mg $114 2024-03-01 Buy
Sigma-Aldrich 33699 Enrofloxacin VETRANAL?, analytical standard 93106-60-6 100mg $72.6 2024-03-01 Buy
Sigma-Aldrich 17849 Enrofloxacin ≥99.0% 93106-60-6 5G $161 2024-03-01 Buy
Sigma-Aldrich 17849 Enrofloxacin ≥99.0% 93106-60-6 25G $619 2024-03-01 Buy
Sigma-Aldrich 1235900 Enrofloxacin United States Pharmacopeia (USP) Reference Standard 93106-60-6 200mg $436 2024-03-01 Buy
Product number Packaging Price Buy
PHR1513 500mg $114 Buy
33699 100mg $72.6 Buy
17849 5G $161 Buy
17849 25G $619 Buy
1235900 200mg $436 Buy

Enrofloxacin Chemical Properties,Uses,Production

Brand Name(s) in US

Baytril

Veterinary fluoroquinolone antimicrobial agents

Enrofloxacin and sarafloxacin, danofloxacin, difloxacin, ofloxacin, norfloxacin, orbifloxacin are commonly used third-generation fluoroquinolone broad-spectrum antimicrobial agents in veterinary clinic at present , is ethyl compound of ciprofloxacin, also known as ethyl ciprofloxacin, ethyl ciprofloxacin, norfloxacin, is effective on Gram-negative bacteria, Gram-positive bacteria and mycoplasma, its antibacterial activity is significantly superior to norfloxacin, the effect on mycoplasma is stronger than tylosin and Tiamulin Fumarate. This product is oral, intramuscular and subcutaneous injection, and is easily absorbed, widely distributed in vivo, in addition to the central nervous system, the concentration of the drug in other organizations, almost all are higher than the blood concentration. De ethylation in vivo, mainly produced active metabolite ciprofloxacin, but different among the animals metabolism are larger, birds, dogs, rabbits and cattle body's metabolic rates are high, horses and pigs body's metabolic rates are lower. Clinically Enrofloxacin is used for the treatment of various mycoplasma disease, and respiratory system, digestive system and urogenital system infections, skin infections and sepsis caused by E. coli, Salmonella, Haemophilus, Erysipelas bacillus, Staphylococcus, Streptococcus etc. Especially suitable for mixing infections caused by a variety of bacteria.
Spatial structure formulae diagram of Enrofloxacin
Spatial structure formulae diagram of Enrofloxacin
The above information is edited by the chemicalbook of Liu Yujie.

Reasonable compatibility

1. Cooperated application of Enrofloxacin with aminoglycoside (gentamicin), third-generation cephalosporins (cefotaxime, ceftriaxone) and penicillin, colistin, may have synergistic antibacterial effect on certain bacteria (especially Pseudomonas aeruginosa or Enterobacteriaceae), in addition to penicillin-type drugs, due to enhanced toxicity, when in combination, need to reduce the dose, and administered separately.
2. Antibacterial activity of Enrofloxacin combined with apramycin enhanced, showed a synergistic effect. The reason was that antibacterial mechanism of apramycin was to specifically hinder biosynthesis of bacterial protein, and thus achieved effect on inhibiting and killing bacteria, while Enrofloxacin could specifically act on subunit A of bacterial DNA gyrase, inhibiting its activity, affecting DNA melting and sealing chain, both of combination had double blocking effect on bacterial replication and translation process.
3. at the same day were successively mixed to drink with colistin sulfate, can improve the efficacy of Enrofloxacin on chicken bacterial disease. and compatibility with SD silver used for the topical treatment of otitis in dogs.
Reference data: Zheng Hugong, Cui Yaoming editor. reasonable compatibility use of veterinary, Zhengzhou: Henan Science and Technology Press, 2009.

Incompatibility

1. Enrofloxacin can inhibit metabolism of theophylline and caffeine, make the blood concentration increase, thereby causing toxic reactions.
2. Combined with anticholinergic drugs (atropine, 654-2) and H2 receptor antagonists (cimetidine, famotidine), making the bioavailability of Enrofloxacin reduce.
3. Enrofloxacin has a role in inhibiting liver drug enzymes, in combination with drugs metabolized in the liver such as erythromycin, lincomycin, etc. making its clearance decrease, blood concentration increased.
4. antacids may reduce absorption of Enrofloxacin in the gastrointestinal tract, not suitable for simultaneous use.
5. mixed with strongly acidic liquid and the strong alkaline liquid and precipitated.
6. Enrofloxacin and metoclopramide occur chemical changes, easy to turn into muddy, should not be mixed injection.

Side effects

Toxicity of Enrofloxacin is less, safe for clinical use. Therapeutic doses have non-teratogenic and mutagenic effect. Can make young animals cartilage occur turbid, causing lameness and pain. Digestive system reactions are vomiting, abdominal pain and bloating. Skin reactions are erythema, pruritus, urticaria and photosensitivity reactions, etc.

Precautions

1. Enrofloxacin aqueous solution was met with light and easy to change color and decompose, should be kept in dark place.
2. Drug-resistant strains of the product showed an increasing trend, not used at sub-therapeutic doses for long-term.
3. Antacids can inhibit the absorption of this product, should be avoided drinking at the same time.
4. In clinical application, can appropriately adjust dosage based on disease, concentration range of drinking water in poultry, per liter of water, added 25 to 100 mg.
5. withdrawal period of chicken is 8 days. Disabled in egg producing period of laying hen.
6. chicks are very sensitive to Enrofloxacin injection, had many poisoning report, the dose should be strictly controlled.

Uses

1. Antimicrobial, for bacteria and mycoplasma infection.
2. New veterinary antimicrobial drugs, broad-spectrum, high efficiency, has special effects on Gram-positive and Gram-negative bacteria and mycoplasma.

Chemical Properties

Pale Yellow Crystals

Uses

Fluorinated quinolone antibacterial

Uses

Enrofloxacin is a broad spectrum antibiotic bactericidal agent used in veterinary medicine to treat animals afflicted with certain bacterial infections.

Definition

ChEBI: A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary ant bacterial agent used for the treatment of pets.

brand name

Baytril (Bayer).

Veterinary Drugs and Treatments

Enrofloxacin is approved for use in dogs and cats (oral only) for the management of diseases associated with bacteria susceptible to enrofloxacin. Because of the dosage restriction (5 mg/kg) for cats, enrofloxacin is generally used in this species only for the most susceptible bacterial infections. It is also been approved for use in cattle (not dairy cattle or veal calves).

5308-25-8
86393-33-1
93106-60-6
Synthesis of Enrofloxacin from 1-Ethylpiperazine and 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Enrofloxacin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 634)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850 +86-13986145403 info@fortunachem.com China 5981 58
Hebei ZB Gamay Biological Technology Co.,Ltd
+86-031189171450 +86-15632359451 chem@zbvet.net China 222 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457 salesvip2@hntmhg.com China 415 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+86-13474506593 +86-13474506593 sarah@tnjone.com China 230 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14936 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682 bruce@xrdchem.cn CHINA 566 55

View Lastest Price from Enrofloxacin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Enrofloxacin pictures 2024-03-29 Enrofloxacin
93106-60-6
US $0.00 / kg 1kg 99% 1000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
Enrofloxacin Base  pictures 2024-03-23 Enrofloxacin Base
93106-60-6
US $0.00 / kg 1kg 99% 1000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
Enrofloxacin pictures 2024-03-16 Enrofloxacin
93106-60-6
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
  • Enrofloxacin pictures
  • Enrofloxacin
    93106-60-6
  • US $0.00 / kg
  • 99%
  • Shaanxi TNJONE Pharmaceutical Co., Ltd
  • Enrofloxacin pictures
  • Enrofloxacin
    93106-60-6
  • US $0.00 / KG
  • 98%+
  • WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Enrofloxacin Spectrum

cfpq Enrofloxacin (200 mg) Enrofloxacin Base API Enrofloxacin-d5 HI Enrofloxacin N-Oxide Hydrochloride Enrofloxacin SynonyMs 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid PD160788 Enrofloxacin Solution, 100ppm Enrofloxacin for system suitability Enrofloxacin Powder enrofloxacin:1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-QUINOLINEcarboxylic acid 1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1 ROFLOXACIN BASE enrofloxacin Baytril ENROFLOXACIN MM(CRM STANDARD) ENROFLOXACIN 99% EnrofloxacinBaseCpv2000 Enrofloxacinebase Baytri 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- Enrolfoxacin Enrofloxacin (base and/or unspecified salts) 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid Enrofloxacin ENROFLOXACIN USP Enrofoxacin 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Enrofloxacin,power 1,4-Dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinolinecarboxylic acid 1-Cyclopropyl-1,4-dihydro-6-fluoro-7-(4-ethylpiperazine-1-yl)-4-oxoquinoline-3-carboxylic acid N-Ethylciprofloxacin Enorfloxacin base 3-quinolinecarboxylicacid,1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl) -6-fluoro-4-oxo- bayvp2674 Enrofloxacin Ep7.0 Enrofloxacin Solution, 1000ppm Pharmaceutical Raw Materials Enrofloxacin For Antibacterial CAS 93106-60-6 Enrofloxacin for system suitability CRS Enrofloxacin Standard Enrofloxacin> Enrofloxacin USP/EP/BP EnrofloxacinQ: What is Enrofloxacin Q: What is the CAS Number of Enrofloxacin Q: What is the storage condition of Enrofloxacin Q: What are the applications of Enrofloxacin Enrofloxacin (EFX), 98% Enrofloxacin (1235900) 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinolinecarboxylic acid ENROFLOXACIN HCL 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinoli Enorofloxacin hydrochloride Enrofloxacine Enorfloxacin Enrofloxacin CRS Enrofloxacin Impurity 2 20% Enrofloxacin oral liquid 10% Enrofloxacin oral liquid 93106-60-6 112732-17-0